ACE2 mRNA – Page 2 – Communicable Diseases Research

Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells

저산소증은 hCMEC/D3 뇌 내피 세포에서 ACE2 및 TMPRSS2 SARS-CoV-2 세포 진입 매개체의 발현을 변경합니다

Article

Published on 2021-11-012022-09-11
Journal: Microvascular research [Category] SARS, 유전자 메커니즘,

Intestinal expression of ACE2 in mice with high-fat diet-induced obesity and neonates exposed to maternal high-fat diet

고지방식이로 인한 비만과 산모 고지방식에 노출된 신생아에서 ACE2의 장 발현

Article

Published on 2021-10-012022-09-11
Journal: Nutrition (Burbank, Los Angeles County, Calif.) [Category] SARS, 치료기술,

[키워드] 2019 novel coronavirus 2019 novel coronavirus disease ACE2 ACE2 mRNA ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 controls coronavirus coronavirus disease COVID-19 digestive disease downregulated evaluate the effect examined expressed expression global health Health High-fat diet Infection intestinal intestinal macrophage intestinal macrophages intestine investigated involved Macrophage macrophages mice mRNA expression Neonatal Neonate Neonates Novel coronavirus novel coronavirus disease obesity offspring opposite outcome Patient patients with COVID-19 proportion receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus Symptom
[DOI] 10.1016/j.nut.2021.111226 PMC 바로가기 [Article Type] Article

Preliminary Evidence for IL-10-Induced ACE2 mRNA Expression in Lung-Derived and Endothelial Cells: Implications for SARS-Cov-2 ARDS Pathogenesis

폐 유래 세포 및 내피 세포에서 IL-10 유도 ACE2 mRNA 발현에 대한 예비 증거: SARS-Cov-2 ARDS 발병에 대한 의미

Immunology

Published on 2021-09-272022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단,

[키워드] “cytokine storm” ACE2 ACE2 expression ACE2 mRNA acute respiratory distress acute respiratory distress syndrome alarmin angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory agent anti-inflammatory cytokine ARDS biguanide binding Calu Calu-3 Calu-3 cell line Cell cell type cell types cells clinic clinically COVID-19 pathogenesis COVID-19 pro-inflammatory cytokines cytokine Cytokine storm Cytokines Disseminated intravascular coagulation elevated Endothelial cell endothelial cells enzyme Evidence evidence of expressed Host IL-10 IL-1β IL-6 in vitro increase in Infection Inflammation intestinal intravascular coagulation investigated losartan lung mechanism metformin modulation Non-pulmonary observation olmesartan organism Other patients preliminary evidence pro-inflammatory cytokines PROTECT provided question receptor Regulation renal required respiratory distress SARS-CoV-2 sartans Spike protein spike protein of SARS-CoV-2 syndrome the spike protein Thromboembolism Treatment upregulate upregulation Vasculitis Viral worse prognosis
[DOI] 10.3389/fimmu.2021.718136 PMC 바로가기 [Article Type] Immunology

Zinc supplementation augments the suppressive effects of repurposed NF-κB inhibitors on ACE2 expression in human lung cell lines

Research article

Published on 2021-09-012022-10-05
Journal: Life sciences [Category] 신약개발,

[키워드] ACE2 ACE2 expression ACE2 mRNA acute respiratory syndrome calu-3 cells Cell cell line cleavage Clinical treatment Combination coronavirus disease downregulate Effect Emetine enzyme expression flow cytometry human lung human lung cells hydrogen peroxide Infection inhibitor inhibitors knockdown knocked down modulated NAC NF-kappa B NF-κB NF-κB signaling P50 PARP protein expression protein levels pyrrolidine dithiocarbamate reactive oxygen specy receptor reduced renin-angiotensin system reversed ROS RT-qPCR SARS-CoV-2 Significance siRNA suppressed surface Treatment Triclabendazole utility was increased were measured western blotting Zinc zinc supplementation
[DOI] 10.1016/j.lfs.2021.119752 [Article Type] Research article

Expression and Possible Significance of ACE2 in the Human Liver, Esophagus, Stomach, and Colon

Research Article

Published on 2021-08-252022-10-31
Journal: Evidence-based Complementary and Alternative Medicine : eCAM [Category] COVID-19,

[키워드] ACE2 ACE2 mRNA ACE2 protein Colon COVID-19 digestive organ damage digestive system enzyme esophagus expressed expression Human human liver investigated liver Liver damage organs Pathogenesis protein expression receptor SARS Coronavirus SARS-CoV-2 Significance stomach Treatment
[DOI] 10.1155/2021/6949902 PMC 바로가기 [Article Type] Research Article

Characterization of ACE Inhibitors and AT 1 R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model

Article

Published on 2021-08-102022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies

SARS-COV-2 감염 연구에 적합한 모델로서 세포주 CL-14, CL-40 및 CAL-51의 확인

Research Article

Published on 2021-08-022022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 mRNA Apoptosis approach Aside biochemical Breast cancer Caco-2 Calu Calu-3 cancer cell line Cell Cell culture cell culture experiment cell culture experiments cell line cell lines cellular cellular entry Colon cancer correlation defined Drug screening entry receptor expression Factor host susceptibility Human Human cancer cell lines human cell lines identification identify Immunity In vitro infection Infection intrinsic LINE missense variant overexpression permissiveness receptor Research resources RNA-seq data SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Scientific community screened the SARS-CoV-2 TMPRSS2 Viral viral entry viral infection virus
[DOI] 10.1371/journal.pone.0255622 PMC 바로가기 [Article Type] Research Article

E-cigarette vape and lung ACE2 expression: Implications for coronavirus vulnerability

전자담배와 폐 ACE2 발현: 코로나바이러스 취약성에 대한 시사점

Article

Published on 2021-08-012022-09-11
Journal: Environmental toxicology and pharmacology [Category] 유전자 메커니즘,

[키워드] ACE2 ACE2 expression ACE2 mRNA Acetylcholine acetylcholine receptor Alter angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 appear Blood blood sampling both sexes changes cigarette coronavirus Coronavirus infection correlation COVID-19 COVID-19 infection downregulated E-cigarette expression female females Human individual Individual differences Infection investigated lung lung tissue male mechanism mice Nicotine Nicotine. not differ Protein receptor respiratory symptoms reveal severe respiratory symptom severe respiratory symptoms significant increase smoking subunit These data underlie viral entry with COVID-19
[DOI] 10.1016/j.etap.2021.103656 PMC 바로가기 [Article Type] Article

ACE2 Is Expressed in Immune Cells That Infiltrate the Placenta in Infection-Associated Preterm Birth

Article

Published on 2021-07-082022-10-31
Journal: Cells [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 mRNA ACE2 protein Bacterial infection Birth Blood CCL2 chorioamnionitis circulation collected COVID-19 cytokine Endothelium exhibited Express expression fetal fraction granulocyte greater healthy immune Immune cell incidence Infiltrate Lipopolysaccharide (LPS) LPS lymphocyte M1 M1/M2 macrophage M2 macrophages Macrophage monocyte Monocytes mRNA mRNA expression neutrophil Neutrophils pathway peripheral Placenta placental positive Pregnancy pregnant women Preterm birth Protein PTB risk SARS-CoV-2 SARS-CoV-2 virus second trimester TNFα Transmission treated was collected
[DOI] 10.3390/cells10071724 PMC 바로가기 [Article Type] Article

Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats—Possible Implications for COVID-19

글리 시르 시리 바 글라브라 추출물을 이용한 식품 농축 래트에서 ACE2 mRNA 및 단백질 발현을 억제합니다.

Article

Published on 2021-07-062022-08-31
Journal: Nutrients [Category] 유전자 메커니즘, 치료제,

[키워드] ACE2 ACE2 expression ACE2 mRNA Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration aldosterone angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 animals body weight Brain Cell component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diet dose Effect enrichment enzyme Evidence experiment expression Extract FIVE food Gene Expression glycyrrhiza glycyrrhizin Hypothesis ileum independent independent of induce inhibitory activity Mild mineralocorticoid receptor organ organs outlined PCR Placebo present protein level RATs receptor reduce reduction respiratory resulting SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant decrease small intestine Stress stress condition stress response Support suppressed susceptibility tissue tissues toll like receptor 4 virus
[DOI] 10.3390/nu13072321 PMC 바로가기 [Article Type] Article