Effect of cannabidiol on apoptosis and cellular interferon and interferon-stimulated gene responses to the SARS-CoV-2 genes ORF8, ORF10 and M proteinSARS-CoV-2 유전자 ORF8, ORF10 및 M 단백질에 대한 세포 사멸 및 세포 인터페론 및 인터페론 자극 유전자 반응에 대한 칸나비디올의 효과Article Published on 2022-07-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] 2′-5′-oligoadenylate synthetase (OAS) family activating acute respiratory syndrome acute respiratory syndrome coronavirus anti-viral response Apoptosis cannabidiol cause Cell cellular Combination component control cell control cells coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Effect expressing expression HEK293 cell HEK293 cells IFNγ immune responses Innate innate immune response innate immune system Innate immunity interferon interferon-stimulated gene interferons M protein marker membrane protein OAS OAS1 OAS2 OAS3 OASL ORF10 ORF8 Plasmid plasmids Prophylaxis Protein readiness respond response SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genes severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). the SARS-CoV-2 transfected cells transfected with treated Treatment vehicle viral gene viral genes viral infection [DOI] 10.1016/j.lfs.2022.120624 PMC 바로가기 [Article Type] Article
Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation바이러스 감염, 세포 사멸 및 염증에서 SARS-CoV-2 뉴클레오캡시드 단백질의 신호 전달 메커니즘Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus assembly caused cell cycle cell cycle arrest cell death complex complexes coronavirus COVID-19 Critical Cytokine storms Cytokines ENhance expression facilitate genomic RNA global public health GSDMD IFN-β in viral induce Infection Inflammation inhibit innate immune system life cycle mechanism N protein NF-κB NF-κB signaling NLRP3 NLRP3 inflammasome pathway Proinflammatory cytokine proinflammatory cytokines promote Protein pyroptosis Replication resulting RNA RNAi RNAi pathway SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus Signaling Smad3 stress granule stress granules survival Transcription undergo viral genome viral life cycle viral replication Viral RNA virus worldwide pandemic [DOI] 10.7150/ijbs.72663 PMC 바로가기 [Article Type] Review
Dengue Infection – Recent Advances in Disease Pathogenesis in the Era of COVID-19뎅기열 감염 - COVID-19 시대의 질병 병인의 최근 발전Review Published on 2022-07-062022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] activated activating advance anti-SARS-CoV-2 Antibody-dependent enhancement antibody-dependent enhancement (ADE) consequence COVID-19 cross-protection cross-reactivity cytokine Cytokine storm demonstrated Dengue dengue (DENV) dengue virus element Endemic endothelial Endothelial dysfunction Host host-virus interactions immune Immune cell immune response Immunopathogenesis impairment implication Inflammasome inflammatory cascade Pathogenesis plasmablast plasmablasts plasmablasts. preclinical study recent response secondary infections serotype severe disease Severity of disease Surveillance virus [DOI] 10.3389/fimmu.2022.889196 PMC 바로가기 [Article Type] Review
Studies in the antiviral molecular mechanisms of 25-hydroxycholesterol: Disturbing cholesterol homeostasis and post-translational modification of proteins25-하이드록시콜레스테롤의 항바이러스 분자 메커니즘 연구: 콜레스테롤 항상성 교란 및 단백질의 번역 후 변형Review Published on 2022-07-052022-09-11 Journal: European journal of pharmacology [Category] 치료제, [키워드] 25-Hydroxycholesterol activating Antiviral antiviral activity antiviral drug antiviral drugs Antiviral mechanism binding catalyzed cholesterol cholesterol homeostasis contribute coronavirus disease Coronavirus disease 2019 Efficiency efficient endoglycosidase endosomal pathway global public health glycan glycans glycosylation hydroxylase impair in vitro in vivo inhibiting Innate immunity Lipid Lipid raft liver Maturity mechanisms Modification molecular mechanism nucleic acid outbreak oxysterol oxysterol-binding protein pathway post-translational modification Post-translational modification. prenylation Previous studies previous study Protein reactive receptor reduce restrict second sensitivity shown Sterol Toxicity Viral protein Viral proteins virus [DOI] 10.1016/j.ejphar.2022.175033 PMC 바로가기 [Article Type] Review
Motivating COVID-19 mitigation actions via personal norm: An extension of the norm activation modelResearch article Published on 2022-07-012022-10-05 Journal: Patient education and counseling [Category] 변종, [키워드] activating Activation approach Ascription of responsibility Awareness of consequences consequence Consequences COVID-19 COVID-19 mitigation cross-sectional demographics driven by effective Effectiveness Efficacy examined extension Health Health Behavior Ideology implication lack liberal Motivating National Norm activation model objective Outcome efficacy Practice promote provide Result severity triggering variable [DOI] 10.1016/j.pec.2021.12.001 [Article Type] Research article
High-affinity FcγRIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19고친화성 FcγRIIIa 유전적 변이체와 강력한 NK 세포 매개 항체 의존성 세포독성(ADCC) 반응이 심각한 COVID-19에 기여Article Published on 2022-07-012022-09-11 Journal: Genetics in medicine : official journal of the Ame [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] activating Activation ADCC ADCC assay antibody antibody-dependent cellular cytotoxicity approach association cell receptor cell receptors cellular cytotoxicity contribute contributing to COVID-19 COVID-19 severity Deceased disease severity Evidence experiments expressing expression FCGR3A FcγRIIIa functional Genetic genetic association Genetic variant genetic variants hallmark Hospitalized hospitalized patient hospitalized patients Immunopathogenesis in vitro investigated limit Mild natural killer NK cell NK cells occur Patient patients with COVID-19 proinflammatory provide receptor response resulting SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 infections Sequence variant. severe COVID-19 severity of COVID-19 significantly significantly higher subsequent variant with COVID-19 [DOI] 10.1016/j.gim.2022.04.005 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article
Serological study of CoronaVac vaccine and booster doses in Chile: immunogenicity and persistence of anti-SARS-CoV-2 spike antibodies칠레의 코로나백 백신 및 부스터 용량에 대한 혈청학적 연구: 항-SARS-CoV-2 스파이크 항체의 면역원성과 지속성Article Published on 2022-06-092022-09-12 Journal: BMC Medicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activating affected age anti-SARS-CoV-2 antibodies antibody antibody production Antibody Response Antibody titer BNT162b2 BNT162b2 vaccine booster booster dose ChAdOx1 ChAdOx1 vaccines collected Combination CoronaVac country Course COVID-19 COVID19 Decline dose elicited ELISA assay generate Heterologous homologous homologous or heterologous humoral Humoral response immunological Immunological memory implementation individual induce interquartile range IQR less magnitude median median age outbreak persistence Prevent remained response SARS-CoV-2 Spike protein the antibody response the disease the SARS-CoV-2 vaccinate vaccination vaccination schedule vaccination. Vaccine [DOI] 10.1186/s12916-022-02406-0 PMC 바로가기 [Article Type] Article
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodiesSARS-CoV-2 숙주 차단은 타고난 NK 세포 기능에 영향을 미치지만 항체 의존적 NK 활성은 스파이크가 아닌 항체를 통해 강력하게 활성화됩니다Article Published on 2022-05-192022-09-11 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] a minor activated activating Activation ADCC ADNKA Analysis antibody Cell cellular immunity correlated cytokine dependent on Depletion Disease progression dominant downregulation Effect Efficacy epithelial cells evade expression functions genetic risk factors identify immune response Immunity immunology Impact implication infected cell Infection Infectious disease Inflammation Innate immunity interferon interferon response Ligand Lung epithelial cells mechanism membrane MHC-I MICA Microbiology minor Most patients natural infection Nectin1 neutralisation NK cell NK cells nsp1 nsp14 nucleocapsid occurred ORF3a outcome overcome Pathogenesis patients pro-inflammatory cytokine protein synthesis Proteins proteomic reduction in response SARS-CoV-2 SARS-CoV2 second dose specific antibodies spike-specific antibodies Spike-specific antibody surface protein sustained the disease ULBP2 understanding vaccination Vaccine Vaccine design vaccine efficacy Vaccine-induced immunity virus viruses viruses. [DOI] 10.7554/eLife.74489 PMC 바로가기 [Article Type] Article
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chipArticle Published on 2022-04-082022-10-04 Journal: Nature Communications [Category] 바이오마커, 변종, 치료제, [키워드] activating Activation Antimicrobial responses Apoptosis attenuate cascade Cell circulating contribute cytokine deformation disease endothelial cells epithelial facilitate H3N2 infection host innate immunity host response human lung immune cells induce Inflammation Inflammatory response Influenza influenza infection inhibitor innate immune response Innate immunity life-threatening lung Lung inflammation Mechanical pandemic Patient physical potential therapeutic target Protective RAGE receptor recruitment reveal Signaling suppress target therapeutic intervention tissue engineering TRPV4 viral burden viral infection viral replication virus [DOI] 10.1038/s41467-022-29562-4 PMC 바로가기 [Article Type] Article