Atypical hemolytic uremic syndrome induced by SARS-CoV2 infection in infants with EXOSC3 mutationArticle Published on 2022-11-012022-11-16 Journal: Pediatric Nephrology (Berlin, Germany) [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Activation affected aHUS. Atypical autosomal-recessive changes in characterized complement Complication COVID-19 Degradation disease disorder dysfunction endothelial cell damage EXOSC3 EXOSC3 mutation genetic disorder Infant Infection kidney mechanism microvascular injury Mutation neurodegenerative nuclear offset Pathogenesis Patient patients rare disease reported resulting RNA RNA exosome SARS-COV-2 infection SARS-CoV2 infection severe COVID-19 the SARS-CoV-2 thrombotic Treatment triggered uremic syndrome Viral RNA [DOI] 10.1007/s00467-022-05566-6 PMC 바로가기
Nitazoxanide and COVID-19: A reviewArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome addition Anti-inflammatory anti-parasitic drug anti-SARS-CoV-2 Antiviral antiviral activity antiviral property ARDS autophagic cause cell death clinical trial Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines distress drug effective finding IFN immunological in silico in vitro study Infection inflammatory disorders inflammatory reaction inhibit Innate immunity interferon lung mammalian mitigate Multi-organ damage nitazoxanide oxidative stress pathogenesis of SARS-CoV-2 pro-inflammatory cytokines pro-inflammatory cytokines. Prospective Study Protozoa Rapamycin reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 infections severe cases syndrome therapy Treatment triggered viral infections Viral pneumonia [DOI] 10.1007/s11033-022-07822-2 PMC 바로가기
ColdZyme® protects airway epithelia from infection with BA.4/5Article Published on 2022-10-312022-11-16 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 변종, [키워드] Activation administration airway airway epithelia applied BA.4 BA.5 block blocked complement contagious Critical Culture epithelial in vitro data Infection Inflammation inflammatory reaction Intervention intrinsic omicron Pathogenesis prevented Prophylaxis PROTECT respiratory tissue SARS-CoV-2 SARS-CoV-2 transmission significantly subsequent Transmission variants variants of concern variants of concern. Viral transmission virus infection VoC VOCs while [DOI] 10.1186/s12931-022-02223-2 PMC 바로가기
Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as MechanismArticle Published on 2022-10-292022-11-15 Journal: Military Medicine [Category] 진단, [키워드] Activation acute respiratory syndrome adverse effect chilblains coronavirus COVID disease infusion interferon mechanism Pfizer presenting rituximab significantly skin lesion Toe Vaccine worsened [DOI] 10.1093/milmed/usab314 PMC 바로가기
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived CellsArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] activate Activation activities activity acute respiratory syndrome betacoronaviruses Cell cellular change coronavirus coronavirus country Critical death downstream Endoplasmic reticulum enzyme ER stress examined expression of gene functions Gene Expression HCoV-OC43 Host host cell host cells host immune system Human human cell human cells imperative individual induce infect Infection inhibit interact IRE1α pathway less limit MERS-CoV MHV Middle East molecular mechanism mRNA murine OC43 Other other coronavirus pathway Prevent processed Replication required Respiratory Coronavirus respiratory syndrome coronavirus Reticulum RNase SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe respiratory disease signaling pathway similarity splice Spread Stress tested the interferon transcription factor Trigger unfolded protein response Unfolded protein response. UPR Vaccine viral replication virus XBP1 [DOI] 10.1128/mbio.02415-22 PMC 바로가기
Brain-computer interface to predict impulse buying behavior using functional near-infrared spectroscopyArticle Published on 2022-10-262022-11-15 Journal: Scientific Reports [Category] 바이오마커, [키워드] Accuracy Activation average Biomarker Brain Evidence functional increase interface limitation memory methodology near-infrared spectroscopy predict previous study provide reduce reported responses Support Travel vaccination against COVID-19 [DOI] 10.1038/s41598-022-22653-8 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
Immunological and Pathological Peculiarity of Severe Acute Respiratory Syndrome Coronavirus 2 Beta VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome analysis Beta Beta variant blockade cascade cause CCL2 Characteristics Comparative analysis coronavirus coronavirus 2 COVID-19 COVID-19 pandemic CXCR2 cytokine cytokine release death Disease progression early stage evidenced IL-1β immunological induce Infection Inflammatory cytokine investigated K18-hACE2 late stage Lung pathology mice molecular mechanism Mortality neutrophil recruitment outbreak pathological pathological condition pathology phenotype presymptomatic provide reduced respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 variant secreted cytokine Strains the SARS-CoV-2 Transcriptome transcriptomes Transmissibility Treatment variant Variant. viral infection weight loss [DOI] 10.1128/spectrum.02371-22 PMC 바로가기
CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responsesArticle Published on 2022-10-242022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] ACE2 activated Activation alleviate Antigen CD169 CD169+ macrophage contribute COVID-19 pathology COVID-19 patients de novo elicited exogenous ACE2 expression expression of SARS-CoV-2 facilitated genomic humans Hyperinflammatory IL-1β IL-6 independent induce Infection innate immune response Macrophage macrophages MDA-5 monocyte myeloid cell Post-mortem primary target cell pro-inflammatory cytokine pro-inflammatory response Remdesivir Replication Restricted RIG-I RNA SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection subgenomic RNA subsequent suppressed the SARS-CoV-2 thought TNFα Treatment viral particle Viral protein Viral RNA [DOI] 10.1371/journal.ppat.1010479 PMC 바로가기
Abrogation of neutrophil inflammatory pathways and potential reduction of neutrophil-related factors in COVID-19 by intravenous immunoglobulinArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] abrogation Activation acute respiratory distress addition Alter ARDS cell-free DNA circulation Clinical treatment Corticosteroids Course COVID-19 COVID-19 patient Critically ill Dexamethasone dose-dependent elevated Ex vivo Factor functions healthy controls healthy donor healthy donors IL-8 inflammatory pathway Intravenous immunoglobulin Intravenous immunoglobulin (IVIG) lack Level Lung injury lung parenchyma modulate NET NETosis NETs neutrophil Neutrophil elastase Neutrophil extracellular trap neutrophil function Neutrophils not affect oxidative oxidative burst Patient Peripheral blood phagocytosis PMA pro-inflammatory function Proteins reactive oxygen specy reduced reduction severity syndrome targeting therapeutic therapeutic agent Tocilizumab tocilizumab. treated Treatment were assessed while with COVID-19 [DOI] 10.3389/fimmu.2022.993720 PMC 바로가기