acute disease – Page 2 – Communicable Diseases Research

Distinguishing Incubation and Acute Disease Stages of Mild-to-Moderate COVID-19

경증에서 중등도의 COVID-19의 배양 및 급성 질환 단계의 구별

Article

Published on 2022-01-202022-09-01
Journal: Viruses [Category] 진단,

Markers for severe disease and long-term sequelae in pediatric patients with severe acute respiratory syndrome coronavirus 2 infection

중증 급성 호흡기 증후군 코로나바이러스 2 감염 소아 환자의 중증 질환 및 장기 후유증 표지자

Article

Published on 2022-01-012022-09-11
Journal: Pediatrics international : official journal of the [Category] SARS, 바이오마커,

[키워드] abnormality acute COVID-19 acute disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adolescence Adults Affect age age distribution bimodal Birth caused Chain Reaction Chest Chest radiograph children chronic chronic disease clinical marker clinical markers Comorbidity Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 defined demographic determine disease Fewer patients infancy Infection Lung disease marker morbidity and mortality MOST obesity oxygen parameter Patient PCR pediatric pediatric COVID-19 Pediatric patient polymerase chain polymerase chain reaction positive positive pressure positive pressure ventilation pressure ventilation Research respiratory retrospective review SARS-CoV-2 SARS-CoV2 severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease significantly supplemental oxygen Symptom symptomatic infection tertiary care hospital the disease
[DOI] 10.1111/ped.15177 PMC 바로가기 [Article Type] Article

Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks

내피 기능 장애는 조절 이상 림프구 반응 및 사이토카인 네트워크와 함께 심각한 COVID-19에 기여합니다

Observational Study

Published on 2021-12-102022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 바이오마커, 임상, 진단, 치료법,

[키워드] activated Activation acute disease Adaptive immunity addition analyses Analysis change Clustering Combination contribute convalescent patient Convalescent patients COVID-19 cytokine disease Disease progression driven by dysfunction dysregulated dysregulation endothelial endothelial injury endothelial integrity expansion flow cytometry granulocyte Granulocytes hallmark hallmarks Hannover ICU patient ICU Patients Immune cell immune cells immune response immune responses immune signature Infectious diseases Inflammatory Inflammatory response Injury involved life-threatening lymphocyte response lymphopenia manifestation medical school microenvironment NK cell observational study plasma protein plasma proteins plasmablast plasmablasts proteomics data regeneration SARS-COV-2 infection SARS-CoV-2-specific antibodies School Seven severe COVID-19 terminally differentiated
[DOI] 10.1038/s41392-021-00819-6 PMC 바로가기 [Article Type] Observational Study

Airway antibodies emerge according to COVID-19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination

기도 항체는 COVID-19 중증도에 따라 나타나고 빠르게 감소하지만 SARS-CoV-2 백신 접종 후 다시 나타남

Research Article

Published on 2021-11-222022-09-12
Journal: JCI Insight [Category] MERS, SARS, 진단,

[키워드] acute disease Adaptive immunity addition airway airways antibodies antibody Antibody Response Antibody responses asymptomatic infection boost clinically Cohort convalescence correlated COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patients COVID-19 severity declined disease elevated evaluated fatal disease highlighting IgA IgG IgG level immune response immune responses immunoglobulins immunology increase in individual individuals infected individual infected individuals Innate immunity mucosal naïve individuals neutralize Prevent prime prime and boost representing required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination significantly subset the antibody response understanding vaccination Vaccinations viral spread virus
[DOI] 10.1172/jci.insight.151463 PMC 바로가기 [Article Type] Research Article

Exposing structural variations in SARS-CoV-2 evolution

SARS-CoV-2 진화의 구조적 변이 노출

Article

Published on 2021-11-112022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 변종,

[키워드] ACE2 acute disease Affect affinity aligned Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 conformational change conformations contributed coronavirus Course Critical delta variant disease effective Effectiveness Evolution function human cells integration lack Lineage Lineage B.1.1.7 Mutation mutations Physicochemical properties physicochemical property physiochemical property Protein protein sequence protein structure residue SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variants Spike protein Structural analysis structural biology Structural variation structural variations Structure structures the SARS-CoV-2 Vaccine variant Viral viral infection virus Virus evolution
[DOI] 10.1038/s41598-021-01650-3 PMC 바로가기 [Article Type] Article

PRO B: evaluating the effect of an alarm-based patient-reported outcome monitoring compared with usual care in metastatic breast cancer patients—study protocol for a randomised controlled trial

PRO B: 전이성 유방암 환자에서 일반 치료와 비교하여 경보 기반 환자 보고 결과 모니터링의 효과 평가 - 무작위 대조 시험을 위한 연구 프로토콜

Study Protocol

Published on 2021-09-282022-09-10
Journal: Trials [Category] SARS, 임상,

[키워드] 1:1 acute disease alarm among others approach ARMS Breast cancer breast cancer patient clinical Clinical practice Complete Contact control arm Controlled trial controls determined by develop disease domain elongation emergency room Endpoint enrolment ePROs fatigue female form Health apps hospitalisation hospitalisations identify include independent intervene Intervention intervention arm intervention group less life Metastatic breast cancer metastatic disease mobile devices outcome Patient Patient-reported outcomes Personalised medicine positive Primary outcome pros protocol Quality of life randomisation randomised randomised controlled trial receive recruited reported symptom reported symptoms required Research secondary Secondary endpoints selected Society supplementary material survival the patient transfer Treatment Trial Trigger usual care Value-based health care
[DOI] 10.1186/s13063-021-05642-6 PMC 바로가기 [Article Type] Study Protocol

Olfactory dysfunction in SARS-CoV-2 infection: Focus on odorant specificity and chronic persistence

SARS-CoV-2 감염의 후각 기능 장애: 냄새 특이성과 만성 지속성을 중심으로

Article

Published on 2021-09-012022-09-11
Journal: American journal of otolaryngology [Category] 치료기술,

[키워드] Ability to smell accompanied Accuracy acute disease acute infection acute SARS-CoV-2 infection affected aldehyde alkali metal analyzed Anosmia antibody Antibody testing Antibody titer average citronellal Cohort Community complete smell loss contingency control group COVID-19 dependent on detect Diagnosis disease dysfunction dysgeusia Fatty acid fatty acids Fever focus healthy control identification IgG IgM indication indications infection with SARS-CoV-2 initial knowledge lemon longitudinal study Lower Microsmia Mild muscle muscle pain no symptom olfactory dysfunction Pain participant patient population persistence positive reduced reduction respiratory tract Result reversal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient SARS-CoV-2 positive patients sense of smell sense of taste sensitivity Smell Smell and taste dysfunction Smell loss smell test soap specificity statistical test Statistical tests strawberry Symptom Taste taste dysfunction Test tested the patient University of Pennsylvania was performed
[DOI] 10.1016/j.amjoto.2021.103014 PMC 바로가기 [Article Type] Article

Antibody Response to SARS-CoV-2 Membrane Protein in Patients of the Acute and Convalescent Phase of COVID-19

COVID-19의 급성 및 회복기 환자에서 SARS-CoV-2 막 단백질에 대한 항체 반응

Immunology

Published on 2021-08-042022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법,

[키워드] acute disease acute phase Amino acid amino acids antibodies antibody antibody reactivity Antibody Response B-cell epitope mapping analyses Complete convalescent phase Course COVID-19 COVID-19 antibody COVID-19 patients disease ELISA epitope Epitopes fusion protein historical control IgM IgM response immunodominant immunodominant epitopes linear epitope longitudinal analysis M protein membrane membrane protein N- and C-termini N-terminus nucleocapsid protein overlap Patient peptide peptides phase plasma samples Protein raised RBD reactivity Recognition response SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins Serological assay serological assays Seropositivity significantly lower specific antibodies synthetic peptide the antibody response the SARS-CoV-2 understanding Vaccines
[DOI] 10.3389/fimmu.2021.679841 PMC 바로가기 [Article Type] Immunology

Frequent and Persistent Salivary Gland Ectasia and Oral Disease After COVID-19

COVID-19 이후 빈번하고 지속적인 타액선 확장증 및 구강 질환

Research Reports

Published on 2021-03-032022-09-10
Journal: Journal of Dental Research [Category] SARS, 치료기술, 치료제,

[키워드] Abnormalities acute disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration antibiotic Antibiotics C-reactive protein C-reactive protein (CRP Cell Characteristics clinical picture clinical recovery connection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated described disease disorders ectasia Epidemiology facial gland Hospital admission hospital dentistry hospital discharge Hospitalized Hyperinflammatory Hyperinflammatory response independent predictor independent predictors Infection infectious disease(s) interquartile range Italy Lactate lactate dehydrogenase LDH majority manifestation Manifestations masticatory muscle median mucosal multivariable analysis muscle weakness oral oral cavity oral manifestations oral pathology organ Pain Patient persist persistent Prevalence prospective cohort study reflected Replication respiratory retrospective Saliva salivary salivary diagnostic salivary gland SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus survived survivor Survivors target target organs Temporomandibular joint Transmission university hospital use of antibiotics virus weakness
[DOI] 10.1177/0022034521997112 PMC 바로가기 [Article Type] Research Reports

Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration

SARS-CoV-2 회복기 동안 감지된 전환 및 전환되지 않은 메모리 B 세포는 제한된 증상 지속 기간과 상관 관계가 있습니다

Research Article

Published on 2021-01-282022-08-13
Journal: PLoS ONE [Category] Biochemistry, 진단, 치료기술,

[키워드] activated acute disease acute respiratory syndrome acute respiratory syndrome coronavirus antibody antibody-secreting plasmablasts B cell B cell response B cell responses B cell subsets causative agent CD24 CD27 characterized classical Clinical outcome composed convalescent Convalescent patients convalescent plasma treatment Coronavirus-2 correlated COVID-19 Critical disease Donor donors duration of symptom enrolled expansion Frequency health emergency identify IGD IgG1 IgM IgM response IgM responses memory memory B cell memory B cells pandemic Peripheral blood plasma antibody positive RBD Receptor binding domain remained respiratory Respiratory illness response responses SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 spike protein receptor binding domain seropositive subjects Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 significant negative correlation significantly Spike protein subject subjects subset symptom duration the SARS-CoV-2 while
[DOI] 10.1371/journal.pone.0244855 PMC 바로가기 [Article Type] Research Article