SARS-CoV-2 infection impairs the insulin/IGF signaling pathway in the lung, liver, adipose tissue, and pancreatic cells via IRF1
SARS-CoV-2 감염은 IRF1을 통해 폐, 간, 지방 조직 및 췌장 세포의 인슐린/IGF 신호 전달 경로를 손상시킵니다
Article
Published on
Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,
Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,
[키워드] Activation
adeno-associated virus
adipose
Adipose tissue
AKT
ameliorated
analyzed
association
Autopsy
Calu3
Calu3 cell
CaLu3 cells
Cell
cell survival
cells
condition
contribute
COVID-19
COVID-19 pathology
COVID-19 patient
COVID-19 patients
COVID-19 severity
Critical
critical patient
critical patients
cytokine
determine
Dexamethasone
diabetes
Diabetic
diabetic patients
Dihydrotestosterone
Endocrine
energy metabolism
European population
evaluate
Evidence
exacerbated
exhibited
Gain
Gene Expression
Genes
GFP
HEK293T
Hospitalized
Host
human ACE2
human cells
hyperglycemia
impair
impairment
infected with SARS-CoV-2
insulin
insulin resistance
Insulin signaling
Insulin/IGF signaling pathway
interferon regulatory factor
Interferone
intron
IRF1
liver
lung
Lungs
male
Male sex
MAPK
metabolic
metabolic abnormalities
Metabolic abnormality
metabolism
mouse model
mTOR
Multiorgan dysfunction
Multiple organ damage
Non-COVID-19
Non-COVID-19 patients
obese
obesity
Older
Older age
Organoid
overexpressing
pancreatic
Pancreatic cell
pancreatic islets
pathology
patients
patients with COVID-19
PI3K
potential mechanism
Prevalence
provide
Regulation
reported
Repository
risk factor
Risk factors
SARS-CoV-2
SARS-CoV-2 infected cell
SARS-CoV-2 infected cells
SARS-COV-2 infection
serotype
severe COVID-19
severity
Signaling
signaling pathway
significantly
stem cell
survival
tissue
tissue damage
Tissue damage.
tissues
Transcriptome
transcriptome dataset
transcriptome datasets
Transgenic mouse
variant
Whole blood
whole blood transcriptome
with COVID-19
[DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.metabol.2022.155236 PMC 바로가기 [Article Type] Article