A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA PolymeraseSARS-CoV-2 RNA 의존성 RNA 중합효소의 최적 뉴클레오티드 유사체 농도 및 속도 제한 뉴클레오티드에 대한 체계적인 연구Article Published on 2022-07-272022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] adenosine analogue Antiviral compounds antiviral efficacy approved assays clinically competition complex Concentration condition cordycepin coronavirus COVID-19 COVID-19 pandemic COVID-19 treatment drug effective Efficiency EIDD-2801 element GS-443902 GS-5734 GTP in vitro new SARS-CoV-2 NUC-7738 nucleoside nucleotide nucleotides physiological Rate RdRP Remdesivir Repurposed drug RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 replication sensitivity the SARS-CoV-2 Treatment [DOI] 10.3390/ijms23158302 PMC 바로가기 [Article Type] Article
Analysis of mitochondrial DNA cytochrome-b (CYB) and ATPase-6 gene mutations in COVID-19 patients코로나19 환자의 미토콘드리아 DNA 시토크롬-b(CYB) 및 ATPase-6 유전자 돌연변이 분석Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] 2019 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine age analyses association ATPase ATPase-6 biochemical parameter Biochemical parameters Blood Blood samples caused Clinical outcome clinical outcomes coronavirus coronavirus disease COVID 19 COVID-19 COVID-19 patient COVID-19 patients creatinine CRP level CRP levels CYB cytochrome defined disease Diseases DNA DNA sequencing ferritin Frequency gene mutation gene mutations genetic mechanism incidence increasingly investigated isolated DNA mitochondrial mitochondrial DNA mtDNA Mutation pandemic Patient PCR populations Sanger sequencing SARS-CoV-2 severe acute respiratory syndrome Coronavirus [DOI] 10.1002/jmv.27704 PMC 바로가기 [Article Type] Article
2′- and 3′-Ribose Modifications of Nucleotide Analogues Establish the Structural Basis to Inhibit the Viral Replication of SARS-CoV-2뉴클레오티드 유사체의 2'- 및 3'-리보스 변형은 SARS-CoV-2의 바이러스 복제를 억제하는 구조적 기초를 확립합니다Article Published on 2022-05-122022-09-11 Journal: The journal of physical chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] active site adenosine Affect analogue Antiviral Basis evaluated extension inhibition Modification molecular molecular dynamics nucleotide nucleotide analogue nucleotide analogues Protein provide RdRP Remdesivir ribose RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp shown stability Structural analysis Treatment [DOI] 10.1021/acs.jpclett.2c00087 PMC 바로가기 [Article Type] Article
Anti-Inflammatory and Antiviral Effects of Cannabinoids in Inhibiting and Preventing SARS-CoV-2 InfectionSARS-CoV-2 감염을 억제하고 예방하는 칸나비노이드의 항염 및 항바이러스 효과Review Published on 2022-04-102022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] adenosine Anti-inflammatory Antiviral Antiviral effect assumed cannabidiol cannabinoid cannabinoids cannabis Cannabis sativa cause caused CBD complex Compound Course COVID-19 COVID-19 pandemic Effect examination excessive immune response glycine GPR55 inflammatory cascade Interaction knowledge Mitigation pandemic Preventing receptors regulate researcher SARS-CoV-2 SARS-CoV-2 virus scientist shown signaling pathways subject Symptoms terpene the disease the SARS-CoV-2 virus therapeutic options Treatment treatment of COVID-19 Trigger TRPV1 Web of Science [DOI] 10.3390/ijms23084170 PMC 바로가기 [Article Type] Review
Suspected Tuberculous Pleurisy and Coronavirus Disease 2019 Comorbidity의심되는 결핵성 흉막염 및 코로나바이러스 질환 2019 동반이환Case Reports Published on 2022-03-152022-09-11 Journal: Internal medicine (Tokyo, Japan) [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine adenosine deaminase anti-SARS-CoV-2 Chain Reaction concerning coronavirus coronavirus disease cough COVID-19 diagnosed Diagnosis diagnostics elevated Fever IgG test initial Patient PCR pharyngitis pleural effusion pleural fluid pleurisy polymerase chain polymerase chain reaction positive public health SARS-CoV-2 spike Suspected thoracentesis Treatment tuberculous Tuberculous Pleurisy tuberculous pleurisy. upper respiratory symptom upper respiratory symptoms [DOI] 10.2169/internalmedicine.6920-21 PMC 바로가기 [Article Type] Case Reports
Potential Cardiotoxic Effects of Remdesivir on Cardiovascular System: A Literature Review심혈관계에 대한 렘데시비르의 잠재적인 심장독성 효과: 문헌 검토Review Published on 2022-03-012022-09-11 Journal: Cardiovascular toxicology [Category] 치료제, [키워드] Abnormalities action potential adenosine amplitude Atrial fibrillation authorization binding bradycardia Cardiac arrest cardiotoxic effects Cardiotoxicity cardiovascular cardiovascular diseases Cell Chloroquine Complete Corona Corona virus COVID-19 COVID-19 disease cytotoxic effect disease dose-dependent manner Effect Effects Emergency Emergency use authorization followed by Hypotension induce inhibit Intravenous remdesivir literature metabolite mitochondrial mitochondrial RNA nucleotide nucleotide prodrug occur pandemic Patient polymerase Potential prolonged QT interval Prospective clinical trial QTC prolongation refractoriness Remdesivir review safety profile significantly sinus bradycardia Spread Treatment ventricular ventricular fibrillation Viral RNA viral RNA synthesis [DOI] 10.1007/s12012-021-09703-9 PMC 바로가기 [Article Type] Review
Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients임상 및 항체 특성은 중증 및 비중증 SARS-CoV-2 환자의 다양한 특징을 나타냅니다.Research Article Published on 2022-02-022022-09-10 Journal: Infectious Diseases of Poverty [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 adenosine adenosine deaminase analyzed antibodies antibody Antibody detection Antibody Response Antibody responses benefit bile acid binding C-reactive protein Characteristics clinical Clinical features clinical information collected contribute correlated COVID-19 COVID-19 case COVID-19 pandemic COVID-19 patient CTD cytokine Cytokines D-dimer domain domains elevated FcγRIIb Fisher’s exact test future therapeutic Ig isotypes IgG subclasses IgG1 IgG3 IL-6 IL-8 immune response investigated IP-10 LDH lymphocyte Lymphocyte count Mann–Whitney U test MCP-1 MCP-3 MIG neutrophil neutrophil count non-severe group NTD Patient patients preventive measure preventive measures procalcitonin Prognosis provide RBD RBD-ACE2 RBM receptors Result SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 spike protein serum sample serum samples severe group Severe patient significantly specificity Spike protein supplementary material Treatment [DOI] 10.1186/s40249-022-00940-w PMC 바로가기 [Article Type] Research Article
5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis5-요오도투베르시딘은 SARS-CoV-2 RNA 합성을 억제합니다Article Published on 2022-02-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] 6-Thio-dG absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenosine ADK antiviral activity antiviral drugs caused Compound compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deoxyguanosine drug exhibited Fludarabine Fludarabine Phosphate functional highlight homolog humans Infectious disease inhibit inhibiting inhibitors inhibitory activity life cycle Novel coronavirus nucleotide nucleotide analogs pandemic phosphate presenting RdRP RdRp inhibitors RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA screened severe acute respiratory syndrome Coronavirus urgency viral life cycle [DOI] 10.1016/j.antiviral.2022.105254 PMC 바로가기 [Article Type] Article
Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and ThromboinflammationCOVID-19 중증도에서 CD39의 역할: 퓨린성 신호 전달 및 혈소판 염증의 조절 장애Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] 95%CI adenosine adjusted odds ratio Admission ADP association ATP Biomarker blocked caused CD39 clinical parameter Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity disorder dysregulation expression Extracellular healthy control homeostasis Hospital stay Hypoxemia hypoxia ICU admission Immune cell indicate Inflammatory Influenza influenza A inhibitor intensive care intensive care unit admission maintain nucleotide nucleotides overexpressed overexpression pathophysiology pathway Patient patients hospitalized plasma platelet activation Pneumonia prospective cohort Purinergic purinergic dysregulation receptor resulting role selected Severe COVID-19 pneumonia severity Signaling subset suggested systemic inflammation Thromboinflammation ticagrelor was related [DOI] 10.3389/fimmu.2022.847894 PMC 바로가기 [Article Type] Immunology
Effectiveness of various cleaning strategies in acute and long-term care facilities during novel corona virus 2019 disease pandemic-related staff shortages새로운 코로나 바이러스 2019 질병 전염병 관련 직원 부족 동안 급성 및 장기 치료 시설에서 다양한 청소 전략의 효과Research Article Published on 2022-01-212022-09-10 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] ACh adenosine adenosine triphosphate allocation assays ATP Care cleaning Cleanliness conditions Contamination contamination rate COVID-19 pandemic Daily Dementia disease Effectiveness electrostatic enhanced enhancement evaluate fogging followed by help hospital in viral infections involved Long-term care not significantly different novel corona virus outbreak Patient performed positive Prevent proportion Randomly reduction rehabilitation removal resource Result RNA room SARS-CoV-2 RNA SARS-CoV-2 RT-PCR shown stationary Swab Transport media ultraviolet light Viral viral transport media wiping [DOI] 10.1371/journal.pone.0261365 PMC 바로가기 [Article Type] Research Article