Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot studySARS-COV-2 감염 및 급성 신장 손상 마커에 의해 유도 된 변경된 신장 기능 COVID-19 환자의 생존 결과를 예측합니다 : 전향 적 파일럿 연구Article Published on 2022-12-012022-08-31 Journal: Renal failure [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute kidney Acute kidney injury adjusted Advancing age Altered Analysis association Biomarker chronic Chronic kidney disease collaboration Comorbidities Comorbidity Control coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 COVID-19 patient COVID-19 patients creatinine Cumulative rates cystatin C death demonstrated elevated examined group groups Hospitalized ICU intensive care intensive care unit investigated Kaplan-Meier method kidney kidney damage Kidney disease Kidney function Kidney function tests Kidney injury literature marker morbidity multivariable Cox regression outcome participant pilot study predict Predictive Predictive value Proteinuria retained risk factor Risk factors SARS-COV-2 infection serum serum creatinine Sex significant difference statistically subject survival survival analysis survival analysis. the Kaplan-Meier method Treatment Urine with COVID-19 [DOI] 10.1080/0886022X.2022.2032743 PMC 바로가기 [Article Type] Article
Immunogenicity and safety of BNT162b2 mRNA vaccine in Chinese adults: A phase 2 randomised clinical trialArticle Published on 2022-12-012022-10-06 Journal: The Lancet Regional Health - Western Pacific [Category] 진단, [키워드] acute respiratory syndrome Administered Adults adverse event AEs age analysis assessment assigned BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine China Chinese clinical trial Complete Completed conducted coronavirus COVID-19 development dose double-blind Efficacy and safety enrolled Follow-up geometric mean titer GMT GMTs Han Chinese healthy immune response immunogenicity immunogenicity endpoint Inc independent individual injection intramuscular Intramuscular injection investigators Laboratory parameters management messenger Messenger RNA Mild moderate mRNA vaccine Neutralising Antibodies neutralising antibody of BNT162b2 participant Participants pharmaceutical Placebo placebo-controlled trial randomisation randomised Randomly reactogenicity receive recipients recruited reduced remained reported resolved Result robust Safety SARS-CoV-2 SARS-CoV-2 variant SCR second dose sera serious AE seroconversion rate severity Shanghai Sponsor statisticians stratified T-cell Response the placebo group Tolerability Treatment Trial utilised vaccination vaccination. vaccine administration were blinded [DOI] 10.1016/j.lanwpc.2022.100586 PMC 바로가기 [Article Type] Article
COVID-19 breakthrough infections and humoral immune response among BNT162b2 vaccinated healthcare workers in Malaysia말레이시아에서 BNT162b2 백신을 접종한 의료 종사자의 COVID-19 획기적인 감염 및 체액성 면역 반응Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] 95% CI affected age Anti-S1 Anti-spike antibody Antibody Response antibody titres association Asymptomatic Asymptomatic individuals blood sample Blood samples BNT162b2 booster vaccination breakthrough Breakthrough infection breakthrough infections collected COVID-19 COVID-19 infection delta variant detectable domain geometric mean geometric mean titre GMT HCWs healthcare healthcare worker Healthcare workers humoral humoral immune response Humoral immunity IgG IgG assay individual individuals Infection investigated Malaysia not different notable outcome Participants prospective cohort study Protein response significantly significantly higher Support symptomatic the antibody response vaccination Vaccine vaccine doses vaccine. waned was measured [DOI] 10.1080/22221751.2022.2065936 PMC 바로가기 [Article Type] Article
Influenza and other respiratory viruses in children: prevalence and clinical featuresArticle Published on 2022-12-012022-11-15 Journal: European Journal of Clinical Microbiology & Infect [Category] 신종인플루엔자, 진단, 치료기술, [키워드] age ARI Asthma clinical feature clinical manifestation collected cough COVID-19 pandemic Epidemic Epidemics Epidemiology female H1N1 ICU Infection Influenza influenza A influenza B other respiratory virus Patient positive Prevalence prevalent real-time RT-PCR respiratory respiratory infection respiratory virus respiratory virus respiratory viruses rhinoviruses RNA extraction specimens study period surveillance. tested virus was performed [DOI] 10.1007/s10096-022-04515-3 PMC 바로가기
Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysisArticle Published on 2022-12-012022-11-16 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 치료기술, [키워드] Abnormalities acute phase acute respiratory syndrome age Analysis articles consequence Control coronavirus coronavirus disease COVID-19 COVID-19 vaccine death Effect Effects evaluate Evidence Follow-up hypogonadism increased risk Infection information intensive care unit investigated male Meta-analysis mRNA mRNA COVID-19 vaccine not affect observational study parameter parameters Patient recovering from COVID-19 reduced retrieved retrospective SARS-CoV-2 Semen Sperm systematic review Testosterone the disease vaccination. [DOI] 10.1007/s40618-022-01801-x PMC 바로가기
SARS-CoV-2 vaccine booster in solid organ transplant recipients previously immunised with inactivated versus mRNA vaccines: A prospective cohort studyArticle Published on 2022-12-012022-10-06 Journal: Lancet Reg Health Am [Category] 진단, [키워드] age All participant anti-SARS-CoV-2 BNT162b2 BNT162b2 vaccine booster Care cohort study CoronaVac COVID-19 determine dose effective end point General population groups Heterologous heterologous vaccine homologous humoral immune response IFN-γ IgG antibody IL-2 inactivated kidney liver median Medicine more difficult mRNA mRNA vaccine neutralising antibody not differ of BNT162b2 outcome Patient priming proportion Prospective prospective cohort study recipient recipients Red SARS-CoV-2 SARS-CoV-2 vaccine School secondary secreting significantly significantly higher solid organ solid organ transplant SOT T-cell T-cell responses vaccination Vaccine vaccine immunogenicity. women [DOI] 10.1016/j.lana.2022.100371 PMC 바로가기 [Article Type] Article
The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors. robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
Safety and immunogenicity of inactivated SARS-CoV-2 vaccines in people living with HIVHIV 보균자에서 비활성화된 SARS-CoV-2 백신의 안전성 및 면역원성Observational Study Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] adverse event age Analysis binding domain booster dose CD4 CD4 count CD4 counts Cell COVID-19 declined Efficacy enrolled evaluated Factor Frequency Gender geometric GMT healthy control healthy controls HIV humoral humoral immune response IgG immune immune response Immunocompromised in both groups inactivated Inactivated vaccine less MBC memory B occurred Patient PLWH predicted prospective observational study reduced remained reported response responses robust Safety Safety. SARS-CoV-2 SARS-CoV-2 vaccine Serious Adverse Event Seven significantly vaccination Viral load with HIV [DOI] 10.1080/22221751.2022.2059401 PMC 바로가기 [Article Type] Observational Study
The vulnerability of maintenance dialysis patients with COVID-19: mortality and risk factors from a developing countryObservational Study Published on 2022-12-012022-10-04 Journal: Annals of Medicine [Category] 임상, [키워드] age Blood Group Characteristics Clinical features collected data complications country COVID-19 death demographics diabetes dialysis epidemiological Factor General population Haemodialysis hospitalisation ICU admission implementation incidence incidence of COVID-19 increased risk independent risk factor infected patient Infection infection control intensive care intubation Male sex measure Measures Mortality mortality rate mortality rate; multivariable logistic regression old age outcomes Patient patients Peritoneal dialysis peritoneal dialysis. positive Predictive reduce required retrospective risk risk factor risk of infection significantly significantly increased smoking study period tested therapy Vascular venous catheter was used West Bank [DOI] 10.1080/07853890.2022.2075914 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 IgG seropositivity after the severe Omicron wave of COVID-19 in Hong KongArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] age Anti-RBD IgG antibody children consequence COVID-19 diagnosed group Health healthcare Hong Kong IgG incidence individual Infection lowest measure nucleoprotein Older omicron ORF8 Public Receptor binding Receptor binding domain reflect SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection seropositive serosurveillance. subclinical infection vaccination variant [DOI] 10.1080/22221751.2022.2106899 PMC 바로가기