Evaluating how has care been affected by the Ontario COVID-19 Opioid Agonist Treatment Guidance: Patients’ and prescribers’ experiences with changes in unsupervised dosingResearch article Published on 2022-04-012022-10-05 Journal: The International Journal on Drug Policy [Category] 치료법, [키워드] affected agonist approach Buprenorphine Care changes in COVID-19 COVID-19 pandemic death disorder dose doses evaluate Evaluating exacerbated facilitate flexibility Health Methadone OAT opioid Opioid agonist treatment outcome pandemic Patient physical distancing measures positive Prescriber questionnaire receive receiving reduce reported researchers Result significantly more Slow-release oral morphine Support Treatment Unsupervised doses [DOI] 10.1016/j.drugpo.2021.103573 [Article Type] Research article
DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonistsDAMP/PAMP는 COVID-19 환자에서 단핵구 TLR 활성화 및 내성을 유도합니다. 핵산 결합 스캐빈저는 이러한 TLR 작용제에 대항할 수 있습니다.Article Published on 2022-04-012022-09-12 Journal: Biomaterials [Category] COVID19(2023년), SARS, 진단, [키워드] Activation agonist anti-viral response binding Blood CD16 COVID-19 COVID-19 patient COVID-19 patients damage Deceased Ex vivo hallmark hyperactivate Hyperactivation hyperinflammation Hyperstimulation ICU ICU patient immunopathology induce Infection Inflammation innate immune intensive care unit limit lung Lungs Major-biological sciences Minor-immunology and inflammation. monocyte Monocytes neutralize nucleic acid outcome patients pattern phenotype proteomics receptors RNA-sequencing SARS-CoV-2 Signaling systemic inflammation the patient TLR TLR agonist TLR stimulation Tolerance Toll-like receptor Treatment viruses [DOI] 10.1016/j.biomaterials.2022.121393 PMC 바로가기 [Article Type] Article
Epicardial adipose tissue in contemporary cardiology Reviews Published on 2022-03-162022-10-05 Journal: Nature reviews. Cardiology [Category] 바이오마커, [키워드] addition adipose agonist Anatomy Atrial fibrillation benefit cardiovascular disease contribute Coronary Coronary artery disease coronavirus disease Cytokines drug fat heart failure highlight inhibitors interest involved Myocardium paracrine Pathogenesis peptide physiological potential therapeutic target pro-inflammatory progression Protective provide receptor Research review risk factor secretion Secretome syndrome tissue Transcriptome translational unique [DOI] 10.1038/s41569-022-00679-9 [Article Type] Reviews
Novel Synthetic Lipopeptides as Potential Mucosal Adjuvants Enhanced SARS-CoV-2 rRBD-Induced Immune ResponseSARS-CoV-2 rRBD 유도 면역 반응을 향상시키는 잠재적 점막 보조제로서의 새로운 합성 리포펩티드Article Published on 2022-03-092022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] activity adjuvant adjuvants Affect agonist agonists Bacterial BALF candidate vaccine charged residue COVID-19 vaccine CSK cytotoxicity Effect enhanced evaluated exhibited Figuring IgA IgG immune response immunized in vitro induce investigated lipopeptide lipoprotein mimicking mucosal N-terminal nasal novel OVA peptide Potential promote RBD residue response rRBD SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 rRBD sequence sera serum significantly increased significantly lower Structure Structure-activity relationship suggested Support support vector machine SVM synthetic the SARS-CoV-2 TLR2 Vaccine vaccine adjuvant [DOI] 10.3389/fimmu.2022.833418 PMC 바로가기 [Article Type] Article
Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory DiseasesReview Published on 2022-03-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] advance Agonism agonist antioxidant application Autoimmune diseases Cell cell damage cellular clinical Clinical practice clinical trials complications Coordinate diabete Diabetic disease disorders dysfunction Enzymes Evidence expression of gene fat homeostasis implication Inflammation Inflammatory bowel disease inflammatory disease metabolic metabolic disease molecular Nrf2 obesity organism oxidative stress Pathogenesis pathway Potential Protein recent regulated Regulation Stress therapeutic use tissue transcription factor understanding [DOI] 10.3390/ijms23052846 PMC 바로가기 [Article Type] Review
Insights From Early Clinical Trials Assessing Response to mRNA SARS-CoV-2 Vaccination in Immunocompromised Patients면역 저하 환자에서 mRNA SARS-CoV-2 백신 접종에 대한 반응을 평가하는 초기 임상 시험의 통찰력Review Published on 2022-03-042022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] adaptive administration agonist animal model Anti-CD19 anti-CD20 anti-CD38 Assessing BNT162b2 CD4 clinical clinical trial component COVID-19 Critical CTLA4 deficiency dose effective Genetic healthy humans immune systems Immunocompromised Immunocompromised patient immunodeficiency Immunosuppressed Immunosuppressive medication inborn errors of immunity increased risk insight jak inhibitors knowledge mRNA mRNA vaccination mRNA vaccine mRNA-1273 mRNA1273 Patient predictor PROTECT response SARS-CoV-2 SARS-CoV-2 vaccination severe disease T-cell the vaccine therapeutic Therapies transplantation Treatment Trial tyrosine vaccination Vaccine [DOI] 10.3389/fimmu.2022.827242 PMC 바로가기 [Article Type] Review
AMP5A modulates Toll-like receptors 7 and 8 single-stranded RNA immune responses in PMA-differentiated THP-1 and PBMCResearch Published on 2022-03-032022-10-29 Journal: Translational Medicine Communications [Category] COVID-19, [키워드] activate activated Activation acute respiratory syndrome addition agonist AhR AMP5A And Chemokines antagonist antiviral immunity Aryl hydrocarbon receptor Autoimmunity biologic chemokines clinical investigation condition coronavirus coronavirus disease Course COVID-19 CXCL10 cytokine Cytokines decrease detect differentially expressed dysregulated Effect ELISA enrichment analysis evaluate experiment fraction Human serum albumin hyperinflammation Hyperinflammatory IL-12 IL-1β IL-6 Imbalance Immune cell immune response immunomodulatory implicated Infection Inflammation inflammatory mediator Inflammatory response inhibit Intervention involved low molecular weight Lung disease mechanism modulate mononuclear cells myeloid cell myeloid cells NF-κB NF-κB activation Osteoarthritis pathway PBMC Peripheral blood PPARγ pro-inflammatory pro-inflammatory cytokine profiles progression Protective provided receptor REP Result resulting RNA Severe case Signaling single-stranded ssRNA suppresse Therapeutic approach THP-1 TLR TLR7 TLR7/8 Toll-like receptor toll-like receptor 7 Toll-like receptor 8 transcription factor transcription factors treat Treatment viral sequences were used with COVID-19 [DOI] 10.1186/s41231-022-00110-y PMC 바로가기 [Article Type] Research
Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious DiseasesReview Published on 2022-02-162022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] accelerated Activation adaptive immune responses adjuvant adjuvants advance agonist Antigen boost COVID-19 pandemic development Diseases Effect effective efficient epidemic diseases Human Vaccines immune response immune responses inactive Infection Infectious disease innate immune responses microbial microbial infection molecular mechanism MPL mRNA vaccine nasal adjuvant pathogen pattern recognition receptor powerful tool PRR recent recognize Research Safe subsequent subunit target TLR TLR agonist TLRs Toll-like receptor Trigger Vaccine [DOI] 10.3390/pharmaceutics14020423 PMC 바로가기 [Article Type] Review
RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infectionResearch article Published on 2022-02-132022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] Activation agonist Antiviral antiviral immunity antiviral response Antiviral treatment approach Brain coronavirus COVID-19 disease severity effective emerging viruses exhibited innate antiviral immunity innate immune Innate immunity K18-hACE2 K18-hACE2 mouse model Ligand lung Lung inflammation mice MT: Oligonucleotides: Therapies and Applications Neutralizing antibody response nucleic acid immunity oropharyngeal swab outcome pandemic Prophylactic PROTECT receptor reduce reduced RIG-I RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Spread survival therapeutic therapy Treatment Type I IFN type I interferon Vaccine viral challenge Viral load virus viruses [DOI] 10.1016/j.omtn.2022.02.008 [Article Type] Research article
Self-Adjuvanting Lipoprotein Conjugate αGalCer-RBD Induces Potent Immunity against SARS-CoV-2 and its Variants of Concern자가 보조 지단백질 접합체 αGalCer-RBD는 SARS-CoV-2 및 우려 변종에 대한 강력한 면역을 유도합니다Article Published on 2022-02-102022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 agonist Alpha Antigen approach B.1.1.529 best Beta Cell Cellular responses concern conjugate coronavirus COVID-19 pandemic COVID-19 vaccine cross-neutralization develop domain effective effective vaccine Effective vaccines humoral iNKT lipoprotein Liposome natural killer neutralization omicron potent Protein RBD Receptor-binding domain respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Spike protein subunit vaccines T cell the RBD Vaccine Vaccines variant variants of concern Viral viral spike protein [DOI] 10.1021/acs.jmedchem.1c02000 PMC 바로가기 [Article Type] Article