COVID-19 Pandemic and Reduced Physical Activity: Is There an Impact on Healthy and Asthmatic Children?Pediatrics Published on 2021-09-082022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] addition Airway inflammation Asthma asthmatic changes in children COVID-19 COVID-19 pandemic Effect Evidence immune system Impact impairing IMPROVE increase Inflammatory diseases lockdown Lung function outcome physical activity Quality of life reduce risk Sedentary behavior suggested susceptibility Symptoms [DOI] 10.3389/fped.2021.695703 PMC 바로가기 [Article Type] Pediatrics
Small airway function in Finnish COVID-19 survivorsLetter to the Editor Published on 2021-08-262023-06-11 Journal: Respiratory Research [Category] MERS, [키워드] Airway inflammation COVID-19 Impulse oscillometry nitric oxide Small airways viral infection [DOI] 10.1186/s12931-021-01830-9 PMC 바로가기 [Article Type] Letter to the Editor
Alveolar Nitric Oxide as a Biomarker of COVID-19 Lung Sequelae: A Pivotal StudyArticle Published on 2021-08-252022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] Accuracy age Airway inflammation alteration alveolar Biomarker Biomarkers bronchiolar change COVID-19 CT scan discharge enrolled Evidence feasible Follow-up functional GGO healthy controls impairment Infection Inflammation investigated knowledge lung lung damage majority membrane Mild nitric oxide organ damage Oxide parameter pathway patients patients hospitalized persistence post-COVID-19 patient Potential predominant radiological respiratory cell SARS-CoV-2 significantly higher utility [DOI] 10.3390/antiox10091350 PMC 바로가기 [Article Type] Article
Adhatoda Vasica attenuates inflammatory and hypoxic responses in preclinical mouse models: potential for repurposing in COVID-19-like conditionsAdhatoda Vasica는 전임상 마우스 모델에서 염증 및 저산소 반응을 약화: COVID-19 유사 조건에서 용도 변경 가능성Research Published on 2021-04-062022-08-31 Journal: Respiratory Research [Category] MERS, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] adaptive Adaptive immunity Adhatoda vasica Airway inflammation Angiogenesis anti-inflammatory effect Anti-inflammatory effects attenuate Bleomycin Blood coagulation cecum Coagulation condition conditions COVID-19 COVID-19 pneumonia downregulation Effect Extract feature fibrosis growth growth factor herbal medicine HIF-1α highlight hyperinflammation hypoxia hypoxic IL-6 IMPROVE Inflammation Inflammatory ligation lung mice molecular Mouse models murine model murine models naïve observation oral administration pathology pathway phenotype Pneumonia pulmonary fibrosis Puncture reduced Replication response Result SARS-CoV2 Sepsis siRNA supplementary material survival rate tested TGF-β1 thrombosis Transcriptome transforming growth factor treated Treatment upregulation Vero Cell Vero cells Viral Viral load [DOI] 10.1186/s12931-021-01698-9 PMC 바로가기 [Article Type] Research
Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody비만 세포 및 호산구 활성화는 COVID-19 및 TLR 매개 바이러스 염증과 관련이 있습니다: 항 Siglec-8 항체에 대한 시사점Immunology Published on 2021-03-102022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 진단, [키워드] Activation administration airway Airway inflammation antibody caused cell activation coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine deplete disease severity elevated eosinophil eosinophils excessive inflammation feature Health Health crisis hyperinflammation Hyperinflammatory Hyperinflammatory response Immune cell immune cells immune response immune responses implicated in vitro in vivo infiltration Inflammation Inflammatory responses inhibit innate immune cell Innate immune cells lirentelimab lung tissues mast cell Mast cells MCs mediators monoclonal antibody pathogenic Pattern recognition pattern recognition receptor Pattern recognition receptors protease Proteases reduced respiratory respiratory viral infection SARS-CoV-2 SARS-COV-2 infection sera Siglec-8 Stimulation suppressed Therapeutic approach Toll-like receptor Treatment Viral viral infection viral infections viral inflammation Viral RNA with COVID-19 [DOI] 10.3389/fimmu.2021.650331 PMC 바로가기 [Article Type] Immunology
Scope of adjuvant therapy using roflumilast, a PDE-4 inhibitor against COVID-19Review article Published on 2021-02-012022-10-05 Journal: Pulmonary pharmacology & therapeutics [Category] 임상, [키워드] “cytokine storm” acute respiratory syndrome Airway inflammation Anti-inflammatory ARD benefit caused Clinical outcome clinical trial combating COPD coronavirus COVID-19 COVID-19 pathogenesis COVID-19 patients effective effective drug identify immune system immunomodulation immunomodulatory inhibitor lung damage Lung function pandemic of COVID-19 Pathogenesis Patient Phosphodiesterase‐4 inhibitor Protective protective effect reducing respiratory disorder respiratory viral Roflumilast SARS-CoV-2 significantly Support therapy Treatment triggered [DOI] 10.1016/j.pupt.2020.101978 [Article Type] Review article
Mechanistic Implications of Biomass-Derived Particulate Matter for Immunity and Immune DisordersReview Published on 2021-01-202022-10-28 Journal: Toxics [Category] COVID-19, [키워드] Affect aggravate Airway inflammation allergic diseases allergic rhinitis Asthma atopic dermatitis biomass cardiovascular diseases cause coronavirus COVID-19 disease Diseases disorder Evidence Health highlighting host defense human diseases hypersensitivity hypersensitivity disorders immune response immune system Immunity immunological immunological effect infections Intervention malignancies matter mitigate modulation molecular molecular mechanism Particulate Particulate matter Pathologies regulate risk susceptibility Tuberculosis [DOI] 10.3390/toxics9020018 PMC 바로가기 [Article Type] Review
A Treatment to Eliminate SARS-CoV-2 Replication in Human Airway Epithelial Cells Is Safe for Inhalation as an Aerosol in Healthy Human Subjects인간 기도 상피 세포에서 SARS-CoV-2 복제를 제거하는 치료법은 건강한 인간 대상에서 에어로졸로 흡입하기에 안전합니다Article Published on 2021-01-012022-08-31 Journal: Respiratory care [Category] SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] Activation aerosol airway Airway inflammation airway pH. Cell cells clinical trial Concentration COVID-19 Defense determine Diseases endosomal trafficking expression had no healthy subjects Host host defense Human human airway epithelial humans impair in vivo Infection inhalation Inhaled inhibited isotonicity Lung function mechanisms multiplicity multiplicity of infection N protein no effect nucleocapsid osmolality Oxygenation Patient patient safety phase Placebo Plaque assay Prevent prevented protein levels raise raised Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral replication subject subjects Treatment Trial USA-WA1/2020 viability Viral viral infection viral replication vital signs was determined [DOI] 10.4187/respcare.08425 PMC 바로가기 [Article Type] Article
A Novel Strategy to Mitigate the Hyperinflammatory Response to COVID-19 by Targeting LeukotrienesPharmacology Published on 2020-08-062022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity acute respiratory distress Airway inflammation ARDS Atypical Case report Clinical course clinical trial coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 progression Cytokine storm dead Dexamethasone Disease progression drug drugs targeting global pandemic host responses Hyperinflammatory hypoxic respiratory failure immune Immune cell indicated infecting Inflammatory response knowledge leukotriene leukotrienes lipid mediator Mild mitigate Multiorgan new virus novel offer Organ failure other coronavirus potential mechanism progression receptor Remdesivir response Result SARS-CoV-2 similarity Strategy syndrome targeting thrombotic complication Treatment Vascular vascular leak vascular leakage virus [DOI] 10.3389/fphar.2020.01214 PMC 바로가기 [Article Type] Pharmacology
Tiotropium Is Predicted to Be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway AnalysisArticle Published on 2020-07-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activate acute respiratory syndrome addition Affect Airway inflammation Antiviral approaches bioinformatics caused Cell chronic obstructive complex Comprehensive COPD coronavirus coronavirus disease COVID-19 COVID-19 patients deregulated drug effective enrichment analyses epithelial expression Genes IL1B IL6 IL8 IMPROVE in vitro in vivo indicated Infection inhibit Interaction Lung fibrosis molecular molecular pathways negative regulation NFkB1 NFKB2 NHBE Ontology outbreak pathologic feature pathway Pathways Patient patients predicted pulmonary disease Pulmonary function Rapamycin reduced RELA RelB Remdesivir Replication rheumatoid arthritis RNA-Seq RNA-seq data SARS-CoV-2 shown significantly the SARS-CoV-2 therapeutic intervention tiotropium TNF upregulated upregulation [DOI] 10.3390/v12070776 PMC 바로가기 [Article Type] Article