Selection for infectivity profiles in slow and fast epidemics, and the rise of SARS-CoV-2 variants느리고 빠른 전염병 및 SARS-CoV-2 변종의 증가에 대한 감염성 프로파일 선택Article Published on 2022-05-192022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] adaptation Alpha alpha and delta variants assessment assessments Characteristics characterized Community Delta delta variant Delta variants develop England Epidemic Epidemics epidemiological Epidemiology estimate Europe Evaluating Evolutionary biology faster Frequency Generation time global health growth growth advantage help increase knowledge pandemic parameter profile risk Risk assessment SARS-CoV-2 SARS-CoV-2 variant Secondary infection secondary infections Selection statistical framework strain Strains the timing Transmission variant variants variants of concern viruses viruses. [DOI] 10.7554/eLife.75791 PMC 바로가기 [Article Type] Article
Humoral, Cellular and Cytokine Immune Responses Against SARS-CoV-2 Variants in COVID-19 Convalescent and Confirmed Patients With Different Disease Severities다양한 질병 중증도를 가진 COVID-19 회복기 및 확인된 환자의 SARS-CoV-2 변이체에 대한 체액, 세포 및 사이토카인 면역 반응Article Published on 2022-05-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ADE Against Alpha alpha and delta variants Alpha variant Anti-RBD IgG cellular Cellular immune response cellular immunity chemokine chemokines Confirmed convalescent convalescent sera correlation COVID-19 Cytokines delta variant Delta variants disease disease severity ELISA ELISPOT evaluate exhibited fold greater humoral Humoral and cellular immune responses humoral immune response Humoral immunity IgG IL-6 immune immune response immune responses Immunity immunoassays individual Inflammatory mediators inflammatory mediators. IP-10 MCP-1 mediators multiplex neutralization potency Neutralizing activity Omicron variant Omicron variants Patient patients performed pseudovirus pseudovirus infection quantified Raji cells RBD-specific IgG response risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant SARS-CoV-2 variants serum severe disease Significant significantly specific antibodies spike-specific antibodies Spike-specific antibody T cell T cells variant virus was measured [DOI] 10.3389/fcimb.2022.862656 PMC 바로가기 [Article Type] Article
Estimation of the basic reproduction number of Alpha and Delta variants of COVID-19 pandemic in Iran이란에서 COVID-19 전염병의 알파 및 델타 변이체의 기본 번식 수 추정Article Published on 2022-05-172022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI Alpha alpha and delta variants Alpha variant applied basic reproduction number Bayesian change changes in computation contagious COVID-19 COVID-19 pandemic Delta delta variant effective Efficiency estimation exponential growth Exponential growth rate growth growth rate Iran mathematical mathematical model Maximum likelihood pandemic Rate statistical model time interval variant variants virus virus spread [DOI] 10.1371/journal.pone.0265489 PMC 바로가기 [Article Type] Article
A database for retrieving information on SARS-CoV-2 S protein mutations based on correlation network analysis상관 네트워크 분석을 기반으로 SARS-CoV-2 S 단백질 돌연변이에 대한 정보를 검색하기 위한 데이터베이스Article Published on 2022-05-042022-09-11 Journal: BMC Genomic Data [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha alpha and delta variants Analysis analysis Atypical Characteristics Combination correlation Correlation network COVID-19 COVID-19 infection COVID-19 infections database Delta variants Evolution Frequency Genome include individual Infection information Local Mu variant Mutation mutations network network analysis over Phylogenetic tree provide recall S protein SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2. South America the S protein These data Transmission dynamics variant variants virus [DOI] 10.1186/s12863-022-01052-y PMC 바로가기 [Article Type] Article
Immunogenicity of BNT162b2 vaccine against the Alpha and Delta variants in immunocompromised patients with systemic inflammatory diseases전신 염증성 질환이 있는 면역 저하 환자에서 알파 및 델타 변이체에 대한 BNT162b2 백신의 면역원성Article Published on 2022-05-012022-09-11 Journal: Annals of the rheumatic diseases [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] abrogated Alpha alpha and delta variants analysed anti-spike antibodies anti-spike antibody anti-Spike IgG B-cell B.1.617.2 BNT162b2 BNT162b2 vaccine Breakthrough infection breakthrough infections Control controls COVID-19 Delta delta variant Delta variants dose effort Endpoint evaluate exhibiting healthcare humoral Humoral response Immune escape immunocompromised individual immunocompromised individuals Immunocompromised patient Immunocompromised patients immunogenicity impairing IMPROVE individual infected with SARS-CoV-2 Inflammatory diseases Kinetics methotrexate mounted neutralisation neutralising Neutralising activity of BNT162b2 Other Patient primary endpoints Prospective raise regimen responses rituximab SARS-CoV-2 secondary Secondary endpoints sera Seroconversion Specific T-cell response strain Strains Support systemic inflammatory disease systemic inflammatory diseases T-cell T-cell Response T-cell responses therapeutic treated vaccination vaccination. Vaccine Viral viral fitness [DOI] 10.1136/annrheumdis-2021-221508 PMC 바로가기 [Article Type] Article
Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis알파 및 델타 SARS-CoV-2 변종 생성 시간: 역학 분석Article Published on 2022-05-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Alpha alpha and delta variants Alpha variant analysed Analysis assumed B.1.1.529 B.1.617.2 Contact tracing Council credible interval decrease delta variant Delta variants determine dominant dominant variant effective Effectiveness Engineering epidemiological faster Generation Generation time genomic sequencing household Households index case Infection Innovation intrinsic Isolation less mathematical occur participant Participants positive PCR test posterior probability recruited reflect responsible SARS-CoV-2 SARS-CoV-2 variant Science security susceptible susceptible individual susceptible individuals Transmissibility Transmission Transmission model transmissions variant virus was used [DOI] 10.1016/S1473-3099(22)00001-9 PMC 바로가기 [Article Type] Article
Differences in Transmission between SARS-CoV-2 Alpha (B.1.1.7) and Delta (B.1.617.2) VariantsSARS-CoV-2 알파(B.1.1.7)와 델타(B.1.617.2) 변종 간의 전파 차이Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI adjusted relative risk Adults Affect age Alpha alpha and delta variants Alpha variant B.1.1.7 B.1.617.2 Characteristics close contact Contact COVID-19 COVID-19 case COVID-19 cases COVID-19 vaccination COVID-19 vaccine Cox regression model Cox regression models Delta delta variant Delta variants difference explain gene target groups higher impact household contact household contacts index case index cases Infectivity Interaction L452R Mutation not differ Older proportion reduce reduced Relative risk reported risk SARS-CoV-2 SARS-COV-2 infection spike spike gene susceptibility TaqMan TaqPath Transmissibility Transmission Transmission. vaccination Vaccination Status variant variants was used were used [DOI] 10.1128/spectrum.00008-22 PMC 바로가기 [Article Type] Article
Estimating the Number of COVID-19 Cases and Impact of New COVID-19 Variants and Vaccination on the Population in Kerman, Iran: A Mathematical Modeling StudyCOVID-19 사례 수와 새로운 COVID-19 변종 및 백신 접종이 이란 케르만 인구에 미치는 영향 추정: 수학적 모델링 연구Article Published on 2022-04-262022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] affected Alpha alpha and delta variants Alpha variant Analysis average calculated calibrated the model case finding chain conducted Contact Contact tracing COVID-19 COVID-19 cases death deaths delta variant dominant effective Hospitalization hospitalizations Impact infected case infected cases Infection interval Iran Isolation limitation Markov Markov chain modeling New number number of infected per day Population predict Prevent promote public education quarantine reducing reported reproductive SEIR Self-isolation social distancing susceptible-exposed-infected-removed the epidemic vaccination Vaccine variant was used [DOI] 10.1155/2022/6624471 PMC 바로가기 [Article Type] Article
Multiplex, Real-Time, Point-of-care RT-LAMP for SARS-CoV-2 Detection Using the HFman ProbeHFman 프로브를 사용한 SARS-CoV-2 검출을 위한 다중, 실시간, 현장 진료 RT-LAMPArticle Published on 2022-03-252022-09-11 Journal: ACS Sensors [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] addition affecting Alpha alpha and delta variants amplification arising binding Chain Reaction clinical sample COVID-19/SARS-CoV-2 Delta variants detection diagnostic diagnostic test DNA DNA polymerase Efficiency evade Evolution extracted RNA gold gold standard HFman probe high-fidelity DNA polymerase Impact isothermal LAMP limitation mechanism multiplex multiplex LAMP nasopharyngeal sample Nasopharyngeal samples nasopharyngeal swabs non-specific non-specific amplification nucleic acid overcome performed POCT point-of-care point-of-care testing (POCT). polymerase chain polymerase chain reaction positive primer probe Quantitative reaction Result reverse transcription RT-LAMP SARS-CoV-2 SARS-CoV-2 viral selective sensitivity sequence sequences specificity Spread subject Tolerance variant variants viral evolution [DOI] 10.1021/acssensors.1c02079 PMC 바로가기 [Article Type] Article
Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of ConcernCOVID-19 회복기의 면역 반응에 대한 종단적 추적은 우려의 다른 SARS-CoV-2 변종에 대한 오미크론 및 시차 손상에 대한 중화 활성의 부재를 나타냅니다Article Published on 2022-03-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] activity Against Alpha alpha and delta variants analyzed antibodies association B cell B cells Beta cellular immunity cellular response Cellular responses changes in clearance Cohort concern Correlation analysis COVID-19 decrease Delta Delta variants Evaluating flow cytometry Gamma humoral humoral and cellular immunity humoral immune response IgG antibody IgG titer immune Immunity indicate indicated individual investigated lack long-lasting longitudinal memory memory B cell memory B cells neutralization capacity neutralization test Neutralizing antibodies neutralizing antibody omicron Omicron variants Other Patient patients persistence Perturbation phenotype Prospective Study protection Protective response SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 variant SARS-CoV-2 variants sera spike Spike-specific memory B cells surrogate virus neutralization test the disease variant variants variants of concern variants of concern. Viral virus neutralization test was measured Wuhan strain [DOI] 10.3389/fimmu.2022.863039 PMC 바로가기 [Article Type] Article