Application of a high-throughput quantitative PCR system for simultaneous monitoring of SARS-CoV-2 variants and other pathogenic viruses in wastewaterArticle Published on 2022-12-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Alpha variant analyzed application applied assays can be used collected Community coronavirus coronavirus disease COVID-19 delta variant demonstrated detect eight epidemiologically FIVE Health High-throughput qPCR highlighting increase Japan L452R labor-intensive likelihood Mie N501Y nine nucleotide nucleotide substitution pathogenic virus pathogenic viruses Pathogenic viruses, SARS-CoV-2 Patient PCR positive prevalent qPCR quantitative PCR quarantine reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant separated Surveillance target tested time-consuming Treatment virus viruses Volume wastewater Yokkaichi [DOI] 10.1016/j.scitotenv.2022.158659 PMC 바로가기
Wastewater to clinical case (WC) ratio of COVID-19 identifies insufficient clinical testing, onset of new variants of concern and population immunity in urban communitiesArticle Published on 2022-12-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] allelic Alpha variant anticipated Canada clinical clinical testing Community complement COVID-19 COVID-19 pandemic decrease Delta VOC diagnostic Effectiveness effort eligibility Endemic epidemiological Epidemiology greater identify Immunity in-depth analysis increases in infection control investigated Metrics occurred omicron Pandemics population immunity proportion public health Public-health reduction reduction in reported required resulting SARS-CoV-2 Seven significant decrease significant increases in significantly Surveillance the disease the SARS-CoV-2 variant variants of concern VoC wastewater wastewater surveillance Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.158547 PMC 바로가기
Building-level wastewater surveillance of SARS-CoV-2 is associated with transmission and variant trends in a university settingArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha variant analyzed associations Building-level surveillance Clinical data clinical testing collected complement Concentration contributed COVID-19 COVID-19 case creating Epidemiology genetic mutation hotspot identify include indicate Intervention Isolation less log N1 and N2 Nucleocapsid gene positive positive control quantification quarantine repeated reported Research SARS-CoV-2 SARS-CoV-2 RNA second wave South spring statistical significance statistically significant Surveillance Transmission university variant variants of concern Viral RNA Viral transmission VOCs Wastewater-based epidemiology [DOI] 10.1016/j.envres.2022.114277 PMC 바로가기
Comparison of CT findings of coronavirus disease 2019 (COVID-19) pneumonia caused by different major variantsArticle Published on 2022-12-012023-07-09 Journal: Japanese journal of radiology [Category] COVID19(2023년), [키워드] 2019 novel coronavirus Alpha variant COVID-19 CT delta variant SARS-CoV-2 [DOI] 10.1007/s11604-022-01301-1 PMC 바로가기
The spike gene target failure (SGTF) genomic signature is highly accurate for the identification of Alpha and Omicron SARS-CoV-2 variantsArticle Published on 2022-11-082022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 치료기술, 치료제, [키워드] 95% CI Accuracy Alpha variant Amino acid Analysis B.1.1.529 B.1.1.7 cause Del detect evaluated genomic Laboratory Mutation omicron positive Positive predictive value Protein resulting RT-PCR S gene SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 variant Sensitivity and specificity sequenced Sequencing spike gene TaqPath tested the Spike Thermo Fisher variant variants of concern VoC [DOI] 10.1038/s41598-022-21564-y PMC 바로가기
Differences in SARS-CoV-2 Clinical Manifestations and Disease Severity in Children and Adolescents by Infecting VariantArticle Published on 2022-11-012022-11-16 Journal: Emerging Infectious Diseases [Category] SARS, 변종, [키워드] acute respiratory syndrome addition Adolescent age Alpha variant children clinical clinical outcomes Co-infection comparable coronavirus coronavirus disease COVID-19 COVID-19 outpatient COVID-19 pandemic Cycle threshold value Delta difference disease disease severity Fever infecting Infection infections Inpatient manifestation omicron parameter Patient Rate respiratory infections respiratory symptom reverse transcription PCR SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome coronavirus 2 Strains Transmissibility underlying condition United States USA variant variants viruses were infected zoonoses [DOI] 10.3201/eid2811.220577 PMC 바로가기
Population-based screening in a municipality after a primary school outbreak of the SARS-CoV-2 Alpha variant, the Netherlands, December 2020-February 2021Article Published on 2022-10-272022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] age Alpha Alpha variant Analysis caused children circulation Clinical symptoms confounders epidemiological link individual infected individual infected individuals Laboratory Lineage B.1.1.7 Netherlands not significantly different outbreak PCR Prevent public health measures questionnaire SAR SARS-CoV-2 SARS-CoV-2 variant School Schools secondary attack rate self-reported symptom sequence Sequencing spread to the mean the SARS-CoV-2 Transmission variant virus virus transmission was determined was used whole genome [DOI] 10.1371/journal.pone.0276696 PMC 바로가기
Infection and Transmission of SARS-CoV-2 B.1.617.2 Lineage (Delta Variant) among Fully Vaccinated IndividualsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Alpha variant Analysis Asia association B.1.1.7 lineage B.1.617.2 Breakthrough infection circulating Cluster Complete conducted coronavirus disease COVID-19 Delta delta variant demonstrated determine diagnostic dominant epidemiologically evaluate Evidence Factor genomic genotyping highest increase in independent individual individuals Infection Infectious virus information Isolation Lineage New York PCR peaked performed phylogenetic clusters positive real-time reverse transcriptase Replication SARS-CoV-2 SARS-CoV-2 lineage secretion sequence spread to subset Surveillance the SARS-CoV-2 Transmission transmission clusters transmission of SARS-CoV-2 vaccinated individual vaccinated individuals vaccination rate Viral load viral RNA load viral titer virological assessment virus Virus titration VoC [DOI] 10.1128/spectrum.00563-22 PMC 바로가기
Comparison of Clinical Characteristics and Outcomes of Hospitalized Patients Infected with the D614G Strain or Alpha Variant of COVID-19 in Taiwan: A Multi-Center Cohort StudyMulticenter Study Published on 2022-10-242023-07-10 Journal: International Journal of Medical Sciences [Category] COVID19(2023년), [키워드] Alpha variant COVID-19 D614G. [DOI] 10.7150/ijms.76725 PMC 바로가기 [Article Type] Multicenter Study
Computational Design and Experimental Validation of ACE2-Derived Peptides as SARS-CoV-2 Receptor Binding Domain InhibitorsArticle Published on 2022-10-202022-11-16 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding Algorithm Alpha variant bind binding binding affinity candidate caused Concentration concentrations COVID-19 pandemic demonstrated disrupt domain ELISA assays entry of SARS-CoV-2 experiments expressed globe host cells human cells inhibitory initial insoluble Interaction moderate Molecular dynamics simulation molecule peptidase peptide Prevent Protein RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2-RBD sequence spike the RBD the SARS-CoV-2 therapeutic These data validation variants virus entry was used Wuhan-Hu-1 α1 helix [DOI] 10.1021/acs.jpcb.2c03918 PMC 바로가기