Detection of SARS-CoV-2 RNA through tandem isothermal gene amplification without reverse transcription역전사 없이 탠덤 등온 유전자 증폭을 통한 SARS-CoV-2 RNA 검출Article Published on 2022-06-152022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Accuracy alternative amplification amplified Analysis cDNA complex composed COVID-19 COVID-19 epidemic Cycling detect detection diagnose Diagnosis DNA emission form G-quadruplex gene amplification generate hairpin structure isothermal Isothermal gene amplification linear primer Primers produced RCA repeated reverse transcription Rolling Rolling circle amplification SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 viral RNA sensitivity single-stranded DNA ssDNA strand Strand displacement amplification subsequent Thioflavin Thioflavin T. viral genes Viral RNA [DOI] 10.1016/j.aca.2022.339909 PMC 바로가기 [Article Type] Article
Infectious Aerosol Capture Mask as Environmental Control to Reduce Spread of Respiratory Viral Particles호흡기 바이러스 입자의 확산을 줄이기 위한 환경 제어로서의 감염성 에어로졸 캡처 마스크Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] activities aerosol aerosol capture airborne isolation. alternative alternatives breath breathing can be used capture CFD collected Computational fluid dynamics Control coughing COVID-19 patient COVID-19 patients Critical described escaped evaluated experiment Filter indicated infected individual infected individuals Isolation Isolation room Laboratory Mask negative Negative pressure nosocomial Nosocomial transmission Particle Particles Patient respiratory RNA RNA copies SARS-CoV-2 Simulation speaking the patient These data Transmission undetectable virus concentration [DOI] 10.3390/v14061275 PMC 바로가기 [Article Type] Article
Anti-inflammatory response of cardamom extract and prediction of therapeutic window in COVID-19 patients by assessing inflammatory markers using RT-PCRRT-PCR을 사용한 염증 마커를 평가함으로써 COVID-19 환자에서 카 다몬 추출물의 항 염증 반응 및 치료 창의 예측Article Published on 2022-06-012022-08-31 Journal: Inflammopharmacology [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] addition alternative Anti-inflammatory anti-inflammatory action anti-inflammatory response Anti-viral association attending physician Awareness breathlessness can not Cardamom Clinical improvement Clinical practice clinician control group cough Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom COVID-19 symptoms CRP Ct values cycle threshold cytokine Cytokine storm dawn Diagnostic method diagnostic test diagnostic tests disease Disease progression dosage dose effective elevated end point enrolled Fever FORTE gene expression profile hospital IL-10 IL-6 India indicate Inflammation Inflammatory marker inflammatory markers inflammatory parameter intake Intervention lack LDH majority material molecular diagnostics morbidity morbidity and mortality multiplex negativity normalized onset of symptom outcome parameter Patient patients PCR test performed popularity potentiality predict Prednisolone prevalent Prognosis Prognosis. protein level provide reason for reducing reported RT-PCR RT-PCR analysis RT-PCR assay RT-PCR test SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 RT-PCR test serum Serum IL-6 sore throat Standard of care standard treatment Steroids Symptom Tablet tested the cytokine storm the patient therapeutic window time TNF- α Treatment treatment arm treatment group were given worsening [DOI] 10.1007/s10787-022-00951-x PMC 바로가기 [Article Type] Article
Comparison of reverse-transcription qPCR and droplet digital PCR for the detection of SARS-CoV-2 in clinical specimens of hospitalized patients입원환자 임상검체에서 SARS-CoV-2 검출을 위한 역전사 qPCR과 droplet digital PCR 비교Article Published on 2022-06-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alternative caused Chain Reaction China clinical Clinical performance coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Critical ddPCR. demonstrated detect Diagnosis Digital digital PCR discharged evidenced Hospitalized hospitalized patient Huoshenshan Hospital N gene negative ORF ORF gene oropharyngeal swab Patient patients patients hospitalized PCR polymerase chain polymerase chain reaction qPCR Quantitative Quantitative detection recovered patients Result reverse transcription risk RT-qPCR SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly specimen target gene Target genes the patient Treatment viral gene viral genes Viral load viral shedding Wuhan [DOI] 10.1016/j.diagmicrobio.2022.115677 PMC 바로가기 [Article Type] Article
Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19중증 COVID-19 환자 치료에서 토실리주맙과 메틸프레드니솔론의 효능 및 안전성 비교Article Published on 2022-06-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] 28-day mortality 95% CI adverse event adverse events alternative caused clinical clinical response comparable COVID Cox regression analysis CRP Dexamethasone dose doses duration of hospitalization Efficacy and safety faster group groups hospitalized patient hospitalized patients ICU admission improvement intravenous methylprednisolone Methylprednisolone not significantly different occurred Other outcome oxygen oxygen saturation Patient Primary outcome problem prospective cohort study secondary Secondary outcomes severe COVID-19 Sleep disturbance Sleep disturbances statistically significant Tocilizumab tocilizumab. Treatment were recorded [DOI] 10.1016/j.intimp.2022.108689 PMC 바로가기 [Article Type] Article
Effectiveness of home-based cardiac telerehabilitation as an alternative to Phase 2 cardiac rehabilitation of coronary heart disease: a systematic review and meta-analysis관상 동맥 심장 질환의 2상 심장 재활의 대안으로 재택 심장 원격 재활의 효과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-05-252022-09-11 Journal: European journal of preventive cardiology [Category] 임상, [키워드] 95% CI 95% confidence interval alternative cardiac Cardiac rehabilitation CENTRAL CHD CINAHL controlled trials Coronary Coronary heart disease COVID-19 pandemic Depression depression score depression scores Effect effective Effectiveness feasible functional functional capacity heart disease Home-based Hospitalization inception increase in life medication Mental Meta-analysis Mobile Mobile application Odds ratio Participation Patient Phase 2 physical physical activity physiological PsycINFO Quality of life Randomized controlled trial RCT RCTs rehabilitation Risk factors searched smoking Suspension systematic review telerehabilitation usual care Web-based. [DOI] 10.1093/eurjpc/zwab106 PMC 바로가기 [Article Type] Meta-Analysis
The Multifaceted Biology of PCSK9PCSK9의 다면적 생물학Review Published on 2022-05-122022-09-11 Journal: Endocrine reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol added alternative analyses binding biological function Biological functions Biology C-terminal Cancer cancer/metastases catalytic domain CD8+ T cells Cell cell surface cellular Characteristics cholesterol circulating Critical cytosolic Dengue domain downregulation ENhance female histocompatibility complex hypercholesterolemia immune Immunotherapy inhibitor LDL LDLR liver low-density Low-density lipoprotein Lysosomes major histocompatibility complex major histocompatibility complex I mechanism membrane-bound Metastasis MHC-I mice modulation monoclonal antibody PCSK9 Protein recent receptor reduce Regulation RNA Safe SARS-CoV-2 secreted Sepsis Septic shock Small interfering RNA sorting statins structure-function T cells T-cell receptor vascular inflammation viral infection viral infections β-cells β-cells. [DOI] 10.1210/endrev/bnab035 PMC 바로가기 [Article Type] Review
Computational prediction of potential inhibitors for SARS-COV-2 main protease based on machine learning, docking, MM-PBSA calculations, and metadynamics기계 학습, 도킹, MM-PBSA 계산 및 메타역학을 기반으로 한 SARS-COV-2 주요 프로테아제에 대한 잠재적 억제제의 컴퓨터 예측Article Published on 2022-04-222022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료제, [키워드] alternative ambenonium approach approved binding energy calculated CHARMM complex Compound compounds COVID-19 dataset described detect Diseases docking docking experiment drug emerging disease enrichment Factor FDA highlighting Histamine histamine receptor HIV-1 reverse transcriptase house inhibit inhibitor input Interaction knowledge lack Metadynamics Mitigation molecules MPro output PDB predict protease Protein protein targets rates of infection receptor researcher reverse transcriptase SARS-CoV-2 main protease SARS-CoV-2 Mpro scored Serotonin strong interaction the epidemic time-consuming Treatment [DOI] 10.1371/journal.pone.0267471 PMC 바로가기 [Article Type] Article
Using information and communication technologies (ICTs) to solve the repressed demand for primary dental care in the Brazilian Unified Health System due to the COVID-19 pandemic: a randomized controlled study protocol nested with a before-and-after study including economic analysis정보 통신 기술(ICT)을 사용하여 COVID-19 전염병으로 인해 브라질 통합 의료 시스템에서 1차 치과 진료에 대한 억압된 수요 해결: 경제 분석을 포함한 전후 연구와 중첩된 무작위 통제 연구 프로토콜Article Published on 2022-04-072022-09-11 Journal: BMC Oral Health [Category] 임상, [키워드] All participant All participants alternative analyses Analysis benefit Care carried Child children clinical trial communication Coronavirus infections COVID-19 COVID-19 pandemic Dental unit develop Effect Effects enrolled feasible health system information Intervention national health system pandemic Perspective platform positive Potential potential benefits primary care Primary outcome Primary outcomes protocol randomization Randomized randomized controlled study RCT receive Registered repressed Research SUS System Teledentistry Telemonitoring Teleorientation. Trial trials [DOI] 10.1186/s12903-022-02101-9 PMC 바로가기 [Article Type] Article
Low-Cost, Real-Time Polymerase Chain Reaction System for Point-of-Care Medical Diagnosis현장 진료 의료 진단을 위한 저비용, 실시간 중합효소 연쇄반응 시스템Article Published on 2022-03-172022-09-11 Journal: Sensors (Basel, Switzerland) [Category] 치료제, [키워드] addition alternative Analysis approach Bill of materials can be used Care chain Chain Reaction circumvent clinics comparable Concentration coronavirus disease Coronavirus disease 2019 COVID-19 described diagnostic disease DNA amplification environmental monitoring faster Fluorescence fluorescence detection fluorescence sensing food food quality gel electrophoresis Health Health care help hospital initial low-cost PCR Measures medical diagnostics optical pandemic PCR performed PID point-of-care point-of-care diagnostics polymerase chain polymerase chain reaction Polymerase chain reaction (PCR) proportional–integral–derivative (PID) controller reaction reagents Real-time PCR real-time PCR system reducing selective sensitivity speed System tested water water quality water quality. [DOI] 10.3390/s22062320 PMC 바로가기 [Article Type] Article