Cellular Uptake and Intracellular Phosphorylation of GS-441524: Implications for Its Effectiveness against COVID-19GS-441524의 세포 흡수 및 세포 내 인산화 : Covid-19에 대한 효과에 대한 영향Review Published on 2021-07-142022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] adenosine adenosine analogs adenosine kinase adenosine levels adenosine transporters alveolar cell alveolar cells alveoli anticancer Antiviral approval cellular cellular uptake clinical effectiveness COVID-19 Critical decrease decreased expression disease effective Effectiveness epithelial cell epithelial cells expressed expression Extracellular GS-441524 healthy hypoxia illnesses Increases increases in Inflammation Intracellular knowledge lead limit Lungs monophosphate nucleoside occur outcome parent nucleoside pharmacokinetic Phosphorylation pneumocyte Pneumocytes protein expression reduced Remdesivir SARS-CoV-2 severe inflammation therapeutic tissue tissues Treatment treatment of COVID-19 triphosphate uptake [DOI] 10.3390/v13071369 PMC 바로가기 [Article Type] Review
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1 + neutrophils and CD14 + monocytesCOVID-19와 RA는 PD-L1 + 호중구 및 CD14 + 단핵구를 구동하는 SPP1 골수성 경로를 공유합니다Research Article Published on 2021-06-182022-09-10 Journal: JCI Insight [Category] MERS, 바이오마커, [키워드] Activation alveoli appear Arthritis Autoimmune diseases BALF Bronchoalveolar lavage fluid cause CD14 CD48 Chronic inflammatory arthritis Cluster Concentration COVID-19 COVID-19 pathogenesis disease driven by FABP4 FCN1 hallmark healthy high plasma levels IHC Infectious disease Inflammation innate response intensive care unit investigation lung Macrophage macrophage cluster macrophage clusters macrophages mechanism mediators monocyte Monocytes myeloid cell neutrophil Neutrophils pathogenic pathology pathway PD-L1 plasma plasma concentrations Pneumonitis predicted Predictive predominant proinflammatory remained rheumatoid arthritis S100A12 severe COVID-19 severe pneumonia SPP1 synovial synovitis tissue trajectory transcriptionally transfer TREM2 unique upstream [DOI] 10.1172/jci.insight.147413 PMC 바로가기 [Article Type] Research Article
Reversed-engineered human alveolar lung-on-a-chip modelArticle Published on 2021-05-112023-07-01 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, [키워드] alveoli distal lung inverse opal lung-on-a-chip three-dimensional [DOI] 10.1073/pnas.2016146118 PMC 바로가기
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discoveryArticle Published on 2021-04-132023-06-15 Journal: Cell Reports [Category] MERS, SARS, [키워드] adult lung epithelium alveolar type 2 cells alveoli COVID-19 Drug discovery interferon primary in vitro model Remdesivir SARS-CoV-2 [DOI] 10.1016/j.celrep.2021.109055 PMC 바로가기
Heterogeneous groups of alveolar type II cells in lung homeostasis and repair폐 항상성 및 복구에서 폐포 유형 II 세포의 이종 그룹Review Published on 2020-12-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] SARS, 유전자 메커니즘, [키워드] allergens alveolar alveolar epithelium Alveolar Type II alveoli AT2 cause Cell cells coronavirus disease Coronavirus disease 2019 COVID-19 differentiation finding function group heterogeneity homeostasis Injury integrity Lineage lung Lung disease lung; maintain marker gene mechanism pandemic Pathogens pathological conditions progenitor repair revelation scRNA-seq Single-cell RNA-sequencing stem cell stem cells subpopulation target targets tissue type II cells virus [DOI] 10.1152/ajpcell.00341.2020 PMC 바로가기 [Article Type] Review
Point-of-care Lung Ultrasound Is Useful to Evaluate Emergency Department Patients for COVID-19현장 진료 폐 초음파는 COVID-19에 대한 응급실 환자를 평가하는 데 유용합니다Endemic Infections Published on 2020-11-282022-09-10 Journal: Western Journal of Emergency Medicine [Category] SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval addition alveoli blinded Chain Reaction Chest Computed tomography condition congestive heart failure coronavirus disease Coronavirus disease 2019 COVID-19 CT findings Department detection rate diagnostic Emergency emergency department evaluated excluded gold gold standard hypothesis test hypoxia inclusion criteria Interpretation involved less life-threatening likelihood ratio lung Lung disease null hypothesis Older P-value Patient performed Pneumonitis point-of-care polymerase polymerase chain polymerase chain reaction Polymerase chain reaction testing positive random random variables respiratory respiratory infection Result retrospective screened sensitivity specificity swabs Symptom symptomatic symptomatic patient Symptomatic patients tested two-sided Ultrasound upper respiratory infection variables Viral vital sign vital signs with COVID-19 [DOI] 10.5811/westjem.2020.8.49205 PMC 바로가기 [Article Type] Endemic Infections