Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascadeShort communication Published on 2022-04-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] 신약개발, [키워드] acute lung injury ameliorated attenuate cascade cytoplasmic drug escitalopram HDAC4 IC50 infiltration Inflammatory responses inhibited inhibiting investigated Lung injury mice morbidity and mortality neutrophil NF-κB signaling nucleus p65 pathway pro-inflammatory cytokine promoted pulmonary injury reduced SIK2 translocated Treatment triggered [DOI] 10.1016/j.bbrc.2022.02.015 [Article Type] Short communication
Impact of the COVID-19 pandemic on management of children and adolescents with Type 1 diabetesResearch Published on 2022-03-102022-10-28 Journal: BMC Pediatrics [Category] Coronavirus, MERS, SARS, [키워드] affected ameliorated black Characteristics children Continuous glucose monitor coronavirus COVID COVID-19 COVID-19 pandemic Depression disease Frequency Generalized linear model Glucose glycemic control Government groups hemoglobin Hemoglobin A1c Hispanic hospital Hospitalization Hospitalized Impact Increased increasing age Local management MONITOR no difference pandemic parent Patient Patient health questionnaire -9 patients pediatric PHQ-9 platform provided Result telehealth Type 1 diabete widespread [DOI] 10.1186/s12887-022-03189-2 PMC 바로가기 [Article Type] Research
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes게놈 전반에 걸친 분석을 통해 SARS-CoV-2 바이러스 유전자 Orf9c가 인간 다능성 줄기 세포 유래 심근세포에 미치는 해로운 영향을 보여줍니다Article Published on 2022-03-082022-09-11 Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated analyses analysis Apoptosis apoptotic approved ATP ATP synthesis cardiac dysfunction cardiac injury cardiomyocyte caused Cell cellular characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined detrimental detrimental effect detrimental effects disease down-regulated drug Drug administration dysfunction electrical ENCODE expression Factor Factors food functional Genes Genome heart disease heart muscle human pluripotent stem cell Impact Inflammation Injury Ivermectin manifestation Manifestations meclizine meclizine. molecular mechanism molecular mechanisms Orf9c overexpression Pathways Protein Proteins Proteomic analysis reduced respiratory restored SARS-CoV-2 SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly stem cell therapeutic approach Transcriptomic analyses Transcriptomic analysis U.S. Food and Drug Administration up-regulated [DOI] 10.1016/j.stemcr.2022.01.014 PMC 바로가기 [Article Type] Article
Inhibitory effects and mechanisms of the anti-covid-19 traditional Chinese prescription, Keguan-1, on acute lung injury급성 폐 손상에 대한 항 코비드 -19 전통 중국 처방, Keguan-1의 억제 효과 및 메커니즘Article Published on 2022-03-012022-08-31 Journal: Journal of ethnopharmacology [Category] MERS, SARS, 비임상, 치료제, [키워드] acute lung injury Adhesion Molecule Administered administration ALI Alpha ameliorated analysed Ang II Angiotensin II ARDS BALF breath cadherin chemokine Chinese claudin Clinical treatment clinical trial collected coronavirus coronavirus disease COVID-19 demonstrated Diseases Effect ELISA Emerging infectious diseases Endothelial cell endothelial injury expression Factor High dose ICAM-1 IL-1β IL-6 IMPROVE incidence Infectious diseases Inflammation Inflammatory Inflammatory factor inflammatory factors inflammatory protein inhibited Injury interleukin intratracheal instillation Keguan-1 keratinocyte lipopolysaccharide low dose LPS lung Lung injury lung tissue lung tissues Macrophage material mechanism medium dose mice Necrosis neutrophil Neutrophils patients with COVID-19 progression proinflammatory protective mechanism Protein provide pulmonary Pulmonary vascular endothelial injury. randomised reduced reducing Registered Seven significantly Support survival rate TCM therapy tight junction TNF-α Traditional Chinese medicine treat Tumour necrosis factor alpha Vascular VE-cadherin was used western blotting [DOI] 10.1016/j.jep.2021.114838 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responsesArticle Published on 2022-02-032022-10-31 Journal: Cell [Category] COVID-19, [키워드] Abstract ACE2 ACE2 binding ACE2 binding site ameliorated analysis antibody Beta binding Booster vaccine change changes in comprehensive analysis convalescent convalescent patient COVID-19 pandemic Delta driven by Evolution facilitate failure Gamma Immune escape immune evasion mAb monoclonal antibody Mutation neutralization neutralization titers neutralize Neutralizing antibody response new SARS-CoV-2 omicron pandemic RBD receptor receptor interaction receptor-binding motif reduce reduced reduction in reported reveal SARS-CoV-2 selective sequence sera spike subject the SARS-CoV-2 titer vaccinated individual vaccine dose vaccinee vaccinees Vaccines variant variants virus viruses widespread [DOI] 10.1016/j.cell.2021.12.046 PMC 바로가기 [Article Type] Article
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron Research Published on 2022-01-212022-10-05 Journal: Nature [Category] SARS, 변종, [키워드] ameliorated B.1.1.529 B.1.1.7 B.1.617.2 Beta Caco2 cells Calu3 cause Delta explain inefficient Infection K18-hACE2 mice Lower respiratory tract lowest Lung pathology mice mortality rate neutralization omicron other variants pathogenicity reduced replication reduction in Replication resulting SARS-CoV-2 therapeutic TMPRSS2 transmembrane serine protease variant variant of SARS-CoV-2 variants virus wild-type SARS-CoV-2 wild-type strain [DOI] 10.1038/s41586-022-04442-5 [Article Type] Research
Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial Research Published on 2022-01-192022-10-05 Journal: Neuropsychopharmacology [Category] 임상, [키워드] Administered administration ameliorated analysis baseline checklist clinical trial Depression determine disorder dose double-blind DSM-5 Effect Effects Efficacy Evidence Interaction intravenous Ketamine less low dose participant Placebo placebo-controlled Posttraumatic Stress primary outcome measure produced PTSD Randomized reduce repeated returned scale secondary secondary outcome measure significantly more Standard dose suggested Symptom Symptoms tested Tolerability Treatment veteran were assessed [DOI] 10.1038/s41386-022-01266-9 [Article Type] Research
3D-printed swab with cover for precision diagnosisEngineering and Nano-Engineering Approaches for Medical Devices Published on 2022-01-042022-10-30 Journal: Journal of Materials Science. Materials in Medicine [Category] COVID-19, [키워드] 3D printing Accuracy ameliorated Diagnosis experiment limit nasal Nasopharyngeal swab PCR test PCR testing Precision Prevent Swab swabs [DOI] 10.1007/s10856-021-06635-2 PMC 바로가기 [Article Type] Engineering and Nano-Engineering Approaches for Medical Devices
Flight attendant occupational nutrition and lifestyle factors associated with COVID-19 incidenceCovid-19 발병과 관련된 승무원 직업 영양 및 생활 양식 요인Article Published on 2021-12-302022-09-10 Journal: Scientific Reports [Category] 치료제, [키워드] 95% CI Administered ameliorated COVID-19 COVID-19 incidence COVID-19 pandemic cross-sectional cross-sectional study Descriptive statistics detect diet ENhance essential worker Essential workers examined Factor Factors Flight attendant food storage Frequency Health healthy healthy diet identify impacted incidence indicated Infrastructure lack limitation Logistic regression mitigate multitude nutrition occupational health potential risk public health questionnaire reported risk Risk factors unique with COVID-19 [DOI] 10.1038/s41598-021-04350-0 PMC 바로가기 [Article Type] Article
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations신장 오르가노이드 및 임상 인구에서 SARS-CoV-2 반응의 교차 검증Research Article Published on 2021-12-222022-09-10 Journal: JCI Insight [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] Alpha ameliorated Apoptosis Beta blocked Cell cell types Clinical data comparable COVID-19 Critical Critically ill Critically ill patient critically ill patients Cross-validation feature gene expression pattern gene expression patterns Genetic diseases infect Infection interferon interferon pathway iPS cells Kidney disease kidney infection kidney organoid kidneys mechanism Molecular pathology morphology Nephrology organ Organoid organoids peptides polycystic kidney polycystic kidney disease Population populations proteomic proximal proximal tubules reflect reflected replicating virus response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral susceptibility target organs Therapeutics Therapies Treatment tropism upregulation Urine variant Viral viral fitness [DOI] 10.1172/jci.insight.154882 PMC 바로가기 [Article Type] Research Article