Amyotrophic lateral sclerosis

[키워드] coiled-coil-containing protein kinase 1 17β-HSD17β-Hydroxysteroid dehydrogenase specificity 17β-Hydroxysteroid dehydrogenase specificity 3β-HSD3β-Hydroxysteroid dehydrogenase specificity 3β-Hydroxysteroid dehydrogenase specificity 4-Hydroxy-trans-2-NonEnal 8-Oxo-2'-deoxyguanosine 8-Oxo-dG8-Oxo-2'-deoxyguanosine AAArachidonic acid ABCATP Binding Cassette ABCG2ATP-binding cassette superfamily G member 2 active transport adverse effect AEadverse effect ALSAmyotrophic lateral sclerosis Amyotrophic lateral sclerosis anthracyclines arachidonic acid ATactive transport ATP Binding Cassette ATP-binding cassette superfamily G member 2 BCBreast cancer beta actin BRAC1breast cancer type 1 Breast Breast cancer breast cancer type 1 Cancer cancer causing genes Cancer stem cells cancerous cells candidate CCcancerous cells CCGscancer causing genes CDKcyclin-dependent kinase clinical trials complications Computational approaches costly COX-2Cyclo-oxygenase 2 CSCscancer stem cells CTsclinical trials cyclin-dependent kinase Cyclo-oxygenase 2 DBFdrug binding frequency DBSdrug binding site death Dehydroepiandrosterone Dehydroepiandrosterone sulfate DHEADehydroepiandrosterone DHEASDehydroepiandrosterone sulfate Di phosphomevalonate decarboxylase Diabetes Mellitus DIdrug induced DMDiabetes mellitus DNA Topoisomerase II Alpha DRdrug resistance drug drug binding frequency drug binding site drug induced drug resistance drug transporters DTsdrug transporters ECMextra cellular matrix EHRselectronic health records Electronic health records EMTEpithelia-Mesenchymal transition EP1prostaglandin E2 receptor 1 Epithelia-Mesenchymal transition ER+Estrogen Receptor-Positive ERCC2Excision repair cross-complementing group 2 EREsestrogen receptor binding elements ERestrogen receptor ERKextracellular signal-regulated kinases estrogen receptor estrogen receptor binding elements Estrogen Receptor-Positive Excision repair cross-complementing group 2 extra cellular matrix extracellular signal-regulated kinases Factors FAKfocal adhesion kinase focal adhesion kinase glutathione S-transferase Glycogen synthase kinase 3 beta GSKβGlycogen synthase kinase 3 beta GSTglutathione S-transferase H-rasHarvey Rat sarcoma virus Harvey Rat sarcoma virus HDHuntington disease HER1/2Human epidermal growth factor receptor 1/2 HER2-Human Epidermal growth factor receptor 2 negative HER2+Human Epidermal growth factor receptor 2 positive HERhuman epidermal growth factor receptor HMG-CoA reductase HMG-CoA Synthase HMGCRHMG-CoA reductase HMGCSHMG-CoA Synthase HNE4-Hydroxy-trans-2-NonEnal HPTHypertension human epidermal growth factor receptor Human epidermal growth factor receptor 1/2 Human Epidermal growth factor receptor 2 negative Human Epidermal growth factor receptor 2 positive Huntington disease hypertension IBDInflammatory bowel disease IGF-1insulin-like growth factor 1 Inflammatory bowel disease information inhibitor insulin-like growth factor 1 Lanosterol synthase LHRHluteinizing hormone-releasing hormone LSSLanosterol synthase luteinizing hormone-releasing hormone malignant cells malondialdehyde mammalian target of rapamycin MAPKmitogen- activated protein kinase matrix metalloproteinase MCmalignant cells MDAmalondialdehyde MDmedian duration MDRmulti-drug resistance median duration membrane transporters MetAP2methionine aminopeptidase-2 methionine aminopeptidase-2 MHS2MutS Homolog 2 microtubules mitogen- activated protein kinase mitoxantrone resistant cells MLH1MutL homolog 1 MMPmatrix metalloproteinase molecular mechanism Mortality MRCmitoxantrone resistant cells MTmicrotubules mTORmammalian target of rapamycin MTsmembrane transporters multi-drug resistance MutL homolog 1 MutS Homolog 2 MVDDi phosphomevalonate decarboxylase NAD(P)H dehydrogenase [quinone] 1 NCCnon-cancerous cells NCENew chemical entity New chemical entity NF-κBNuclear factor kappa-light-chain-enhancer of activated B cell Nitric Oxide Synthase 3 non-cancerous cells Non-profit organisations non-steroidal anti-inflammatory medicine NOS3Nitric Oxide Synthase 3 NPONon-profit organisations NQO1NAD(P)H dehydrogenase [quinone] 1 NSAIDnon-steroidal anti-inflammatory medicine Nuclear factor kappa-light-chain-enhancer of activated B cell occur OCT1organic cation transporter 1 organic cation transporter 1 P-glycoprotein P-gpP-glycoprotein p53Tumor protein p53 PEG2/PGH2prostaglandin E2 PR+Progesterone Positive Progesterone Positive progesterone receptor prostaglandin E2 prostaglandin E2 receptor 1 proteomics provide PRprogesterone receptor Rac1Ras-related C3 botulinum toxin substrate 1 Randomised clinical trials Ras homolog family member A Ras-related C3 botulinum toxin substrate 1 RCTsRandomised clinical trials reactive oxygen species Receptor tyrosine kinase Repurposed drug responsible Rho-ARas homolog family member A rho-associated Ribosomal protein S6 kinase rising ROCK1rho-associated ROSreactive oxygen species RTKReceptor tyrosine kinase S6KRibosomal protein S6 kinase Scientific community SCstromal cells SCTssolute carrier transporters selective estrogen receptor degrader selective estrogen receptor modulator sequential strategies SERDselective estrogen receptor degrader SERM Side effects signal transducer and activator of transcription 3 SIRT1/2sirtuin (silent mating type information regulation 2 homolog) ½ sirtuin (silent mating type information regulation 2 homolog) ½ SLC22A16Solute Carrier Family 22 Member 16 SMAD 2/3/4SMAD family member 2/3/4 SMAD family member 2/3/4 Solute Carrier Family 22 Member 16 solute carrier transporters Sp1/3/4specificity protein 1/3/4 specificity protein 1/3/4 SQLESqualene monooxygenase Squalene monooxygenase SSsequential strategies STAT3signal transducer and activator of transcription 3 stromal cells subject survival TAEtopoisomerase alteration expression Tamoxifen TAMTamoxifen TCtumour cells TGFαTransforming growth factor-alpha TGFβ-RITransforming growth factor-beta type 1 receptor TGFβ1/β2Transforming growth factor beta1/2 TOP2ADNA Topoisomerase II Alpha topoisomerase alteration expression TP53tumor protein Transforming growth factor beta1/2 Transforming growth factor-alpha Transforming growth factor-beta type 1 receptor Treatment treatment-related side effects TRPtumour resistance profile TSEtreatment-related side effects tumor protein Tumor protein p53 tumour cells tumour resistance profile vascular endothelial growth factor VEGFvascular endothelial growth factor women xanthine dehydrogenase XDHxanthine dehydrogenase β-actbeta actin
[DOI] 10.1016/j.biopha.2021.112375 [Article Type] Review article