Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Association of iron-related biomarkers with severity and mortality in COVID-19 patientsArticle Published on 2022-12-012022-11-15 Journal: Journal of trace elements in medicine and biology [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] Activation Analysis analyzed association AUC biological processes Biomarker can be used characterized Combination continuous monitoring contribute Control controls Course COVID COVID 19 COVID-19 COVID-19 patient cutoff point Deceased decrease deficiency demonstrated discharged ferritin healthy individual highest IL-6 immune responses immune system immunomodulatory individual infected with COVID-19 Infection Inflammation iron marker material Mild moderate Mortality multiple regression model outcome oxidative stress parameter patients with COVID-19 receiver operating characteristic recruited regulate required ROC ROC Curve SARS-CoV-2 patients sensitivity serum severe disease severity shown significant difference significantly significantly increased specificity stepwise AIC selection survival susceptibility the cytokine storm the median trace Trace element Trace metals Transferrin Transferrin. variable variety viral infections [DOI] 10.1016/j.jtemb.2022.127075 PMC 바로가기
Variation in SARS-CoV-2 seroprevalence in children in the region of Asturias, Northern SpainArticle Published on 2022-12-012022-11-15 Journal: World Journal of Pediatrics [Category] COVID19(2023년), SARS, 진단, [키워드] 95% CI 95% confidence interval acute respiratory syndrome analyzed antibodies Asturias change Child children close contact collected Contact tracing coronavirus coronavirus disease COVID-19 epidemiological estimate Evolution of SARS-CoV-2 Factor fatigue Features longitudinal change median age multicenter multivariable analysis occurred positive Prospective public health recruited SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody test SARS-CoV-2 seroprevalence seroepidemiologic studies. seronegative seropositive Spain subject Symptom Symptoms variable venous blood Virological virological test [DOI] 10.1007/s12519-022-00617-2 PMC 바로가기
Inflammatory bowel disease patient concerns and experiences on transition to home-based infusions during the COVID-19 pandemicArticle Published on 2022-12-012022-11-15 Journal: Research in social & administrative pharmacy : RSA [Category] 진단, [키워드] adverse event age analyzed approach biologics bowel Care category CDC Characteristics collected conducted COVID-19 COVID-19 pandemic COVID-19 transmission disease Factor Guidance Inflammatory bowel disease Infusions. initial iterative one patient outcome pandemic participant Patient performed persistence positive resolved social distancing transitioned [DOI] 10.1016/j.sapharm.2022.06.009 PMC 바로가기
The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors. robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
Maternal SARS-CoV-2 sero-surveillance using newborn dried blood spot (DBS) screening specimens highlights extent of low vaccine uptake in pregnant womenArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Adults analyzed Antibody concentrations Antibody neutralization Blood complications contributing to COVID COVID-19 delta variant dose Dried blood spots fetal General population help highlight Hospital admissions Immunity IMPROVE information Intervention Maternal MONITOR natural infection Newborn newborn screening omicron outcomes pregnant women proportion reduction in representing Result SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies serostatus specimen the SARS-CoV-2 the vaccine utility vaccination vaccination. Vaccine women [DOI] 10.1080/21645515.2022.2089498 PMC 바로가기
The heterogeneous mixing model of COVID-19 with interventionsArticle Published on 2022-11-212022-11-16 Journal: Journal of theoretical biology [Category] 변종, [키워드] Admission age analyzed Breakthrough infection caused China conducted Control Control reproduction number Coverage COVID-19 COVID-19 transmission death effective Effectiveness Epidemic evaluate Future group heterogeneity heterogeneous Heterogeneous mixing Infection Intervention manuscript measure mechanism mutant strain Mutant strains Prevent Prevent infection preventing infection reduce Reproduction number stability submitted Transmission vaccination vaccination strategies. Vaccination strategy Vaccine Vaccines [DOI] 10.1016/j.jtbi.2022.111258 PMC 바로가기
Whole-genome sequence analysis reveals the circulation of multiple SARS-CoV-2 variants of concern in Nairobi and neighboring counties, Kenya between March and July 2021Article Published on 2022-11-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] adaptive analysis analyzed B.1.1.7 B.1.351 B.1.617.2 Beta bioinformatics circulation community transmission comparison Coronaviruses COVID-19 COVID-19 cases Delta Epidemics genome sequence increase in Kenya Lineage majority Mutation Neutralizing antibodies Oxford Nanopore Technologies Phylogenetic Prevalence protocol reduced Region regions reveal RNA RT-PCR SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2. sequence Sequence analysis Sequencing Spread Strains study period the SARS-CoV-2 variant virulence virus virus transmissibility VoC was performed [DOI] 10.1186/s12985-022-01895-y PMC 바로가기
Practical considerations to establish a validated platform for pooled detection of SARS-CoV-2 by droplet digital PCRArticle Published on 2022-11-042022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] addition affected amplification analyzed approach Blood carried COVID-19 pandemic Critical Ct value detect detection diagnostic diagnostic capabilities digital PCR Dilution droplet False negative Health hospital Infectious disease inhibitors invasive Laboratory less limitation Nasopharyngeal samples parameter PCR platform pool positive sample reagent reagents reduce reducing resources resulting risk Saliva SARS-CoV-2 sensitivity the SARS-CoV-2 virus load was performed [DOI] 10.1371/journal.pone.0271860 PMC 바로가기
Effects of the Omicron variant on perinatal outcomes in full-term neonatesArticle Published on 2022-11-032022-11-16 Journal: BMC Pediatrics [Category] SARS, 변종, [키워드] absence analyzed APGAR score complications conducted coronavirus disease COVID COVID-19 criteria demonstrated Effect enrolled exclusion criteria Full-term neonate Infection investigated Isolation Korean Mortality mother Neonatal resuscitation Neonate Newborn non-infectious omicron Omicron variant outcome outcomes Perinatal Perinatal outcomes. Pregnancy required Research Respiratory Support Self-isolation Seven significant difference single center symptomatic symptomatic and asymptomatic tachypnea variant were excluded [DOI] 10.1186/s12887-022-03690-8 PMC 바로가기