Detailed videocapillaroscopic microvascular changes detectable in adult COVID-19 survivors성인 COVID-19 생존자에서 감지할 수 있는 상세한 비디오모세혈관경 미세혈관 변화Article Published on 2022-07-012022-09-11 Journal: Microvascular research [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] age Analysis Angiogenesis Capillaries capillary cause change CNT concerning concomitant therapies contrary control group control groups control subject control subjects controls COVID-19 detectable disease disease onset disease severity Effect endothelial cells Endothelial dysfunction evaluate Frequency Giant Glucocorticoids induce less linear Microcirculation Multivariate analysis Nailfold capillaroscopy no statistically significant difference organ damage parameter Patient raynaud s phenomenon Raynaud's phenomenon reduced SARS-CoV-2 SARS-CoV-2. scored searched selective significantly significantly lower statistically significant difference survivor Therapies therapy [DOI] 10.1016/j.mvr.2022.104361 PMC 바로가기 [Article Type] Article
Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?SARS-CoV-2가 표적으로 하는 고혈당증, 당뇨병 합병증 및 인간 단백질의 유전자 네트워크: 동반 질환의 분자적 근거는 무엇입니까?Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 ANDSystem Angiogenesis applied approach associative Basis Beta beta cell Beta cells bioinformatics Bioinformatics analysis BRD2 Cell Comorbidity Complication complications COMT COVID-19 CTSB CTSL defined degranulation determine diabete diabetes Diabetic diabetic complications disorder DNMT1 DPP4 dysfunction enrichment analysis ERP44 expand F2RL1 GDF15 gene networks Gene ontology General population GPX1 HDAC2 HMOX1 Human HYOU1 hyperglycemia hypoxia IDE identify immune Inflammatory response insulin insulin resistance insulin resistance. intracellular protein involved LOX mechanism metabolism molecular basis molecular network network NUTF2 organ damage oxygen pathophysiological patients with diabetes PCNT PLAT Platelet protease Proteins RAB10 reactive oxygen specy reconstructed Regulation RHOA SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 entry receptor SCARB1 SELENOS severe COVID-19 TMPRSS2 Vascular [DOI] 10.3390/ijms23137247 PMC 바로가기 [Article Type] Article
Pulmonary and Systemic Pathology in COVID-19Article Published on 2022-06-242022-11-15 Journal: Deutsches Ärzteblatt international [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory distress affected Alter analysis Angiogenesis ARDS arise Autopsy Brain cardiovascular system Central nervous system change clinical picture concerning contribute COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients disease Endothelium Evidence gastrointestinal tract interstitial invagination Ischemia kidneys liver Lungs mechanisms molecular organ organ damage outbreak pandemic pathophysiology Placenta pulmonary Regulatory retrieved risk factor selective severe cases syndrome systemic thrombosis tissue various tissue vessel [DOI] 10.3238/arztebl.m2022.0231 PMC 바로가기
COVID-19 and retinal degenerative diseases: Promising link “Kaempferol”Review article Published on 2022-06-012022-10-05 Journal: Current opinion in pharmacology [Category] 바이오마커, 신약개발, 치료제, [키워드] affected Angiogenesis Apoptosis autophagy Care caused cellular signaling pathway COVID-19 degenerative demonstrated disease Effect hallmark hazards Health Inflammation involved management Mortality natural other diseases outbreak Regulatory Side effect syndrome [DOI] 10.1016/j.coph.2022.102231 [Article Type] Review article
SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an α v β 3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing AntibodiesSARS-CoV-2는 백신 유도 중화 항체가 있는 경우에도 α v β 3 인테그린 매개 세포내이입을 통해 인간 ACE2 음성 내피 세포를 감염시킵니다Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] absence ACE2 acute respiratory syndrome Angiogenesis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-spike antibodies antibody BNT162b2 BNT162b2 vaccine Cell clathrin conserved endocytosis Endothelial cell endothelial cell dysfunction endothelial cells enzyme Evidence expression functional gateway highlight Human human lung impair Infection inhibit SARS-CoV-2 integrin integrin-mediated Integrins Interaction Intervention Lineage maintain monoclonal antibody motif neutralize phenotype Presence Prevent productive viral replication promote Protein RBD Receptor binding domain respiratory responsible RGD motif SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants sequence Spike protein the SARS-CoV-2 the Spike the vaccine vaccination Viral viral envelope virus virus viruses αvβ3 integrin αvβ3 integrin. [DOI] 10.3390/v14040705 PMC 바로가기 [Article Type] Article
Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway Research Published on 2022-03-222022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] activate activated Activation Angiogenesis anti-IL6 antibody binding blocking Cell complications Consensus conserved Coverage COVID-19 patient Culture disease downstream Endothelial cell endothelial cells Ex vivo exhibited expression glycoprotein greater growth human lung IL-6 interleukin-6 liver Local Lrg1 observation pathogenic pathway Phosphorylation physiological condition produced promote promoted promoter receptor reduced resulting secreted significantly STAT3 stimulate therapy Transcription Treatment utility Vascular vessel [DOI] 10.1038/s41598-022-08516-2 [Article Type] Research
Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function임상적으로 사용되는 미세소관 표적 약물이 바이러스 감염 및 전달 기능에 미치는 영향Article Published on 2022-03-222022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] analyzed Angiogenesis antiviral activity antivirals biochemical cellular clinically complex compounds correlation crystal structure cytoskeleton DNA and RNA drug drugs Effect function High-resolution higher impact Infection information living cells Mebendazole mebendazole-tubulin complex crystal structure mechanism microtubule microtubule targeting drugs. molecular mechanism movement peptide provided RNA viruses SARS-CoV-2 Structure targeting tested these compound these compounds Toxicity Transport viral infection viral infections viruses [DOI] 10.3390/ijms23073448 PMC 바로가기 [Article Type] Article
How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment혈액의 타고난 면역 체계가 COVID-19 유발 ARDS의 전신 병리에 기여하고 치료를 위한 잠재적인 표적을 제공하는 방법Review Published on 2022-03-082022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation Acute kidney injury acute respiratory distress acute respiratory distress syndrome AMY-101 Angiogenesis apoptotic cells ARDS Biomarker bradykinin candidate drug candidate drugs cascade cascade system characterized chemokines Coagulation Coagulation system complement Complement inhibitor complement inhibitors Compound COVID-19 Crosstalk cytokine Cytokines damaged demonstrated dysregulation ecallantide eculizumab Evidence favor ground glass opacities heparin High dose high risk Icatibant IL-6 IL-6 levels in some incidence include Influenza influenza-like symptom Influenza-like symptoms inhibitor initiated Innate innate immune system intensive care treatment Kallikrein lanadelumab lead leukocytes life-threatening LMWH Lung injury mechanical ventilation mechanism moderate MOST oxygen oxygen saturation pandemic pathophysiology Patient patients Phase I plasma plasma proteins Platelets platelets. Potential predict Prevent Prognostic value pulmonary damage pulmonary inflammation receptor reduced Regulation respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 infected patient severity Support survival syndrome System systemic target the disease therapeutic option therapeutic options Thromboembolism thrombosis thrombotic Thrombotic complications translated Treatment treatment of COVID-19 Trial Usage Vascular ventilator virus [DOI] 10.3389/fimmu.2022.840137 PMC 바로가기 [Article Type] Review
Hepatitis B Virus Small Envelope Protein Promotes Hepatocellular Carcinoma Angiogenesis via Endoplasmic Reticulum Stress Signaling To Upregulate the Expression of Vascular Endothelial Growth Factor AArticle Published on 2022-02-232023-06-13 Journal: Journal of Virology [Category] B형 간염, Fulltext, [키워드] Angiogenesis HBV small surface proteins Hepatocellular carcinoma unfolded protein response vascular endothelial growth factor A. [DOI] 10.1128/JVI.01975-21 PMC 바로가기
Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors TreatmentReview Published on 2022-02-082023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Angiogenesis CAR-T cell immunotherapy chemokines Immune checkpoints solid tumor Tumor Homing tumor microenvironment Tumor stroma [DOI] 10.3389/fimmu.2022.830292 PMC 바로가기 [Article Type] Review