The Impact of COVID-19 on Cancer Recurrence: A Narrative ReviewReview Published on 2022-07-012023-07-10 Journal: Archives of Iranian medicine [Category] COVID19(2023년), [키워드] angiotensin converting enzyme Cancer COVID-19 Dormant cancer cells Inflammation Interleukins Metastasis Neutrophil extracellular traps recurrence. [DOI] 10.34172/aim.2022.74 PMC 바로가기 [Article Type] Review
Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infectionsSARS-CoV-2 감염의 동반 질환 관련 단백질에 대한 Momordica dioica의 예측 의약 대사 산물Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ADME angiotensin angiotensin converting enzyme antidiabetic Antiviral binding binding affinities Blood brain barrier cardiovascular disease catechin comorbid comorbid condition comorbid conditions Comorbidity Compound correlated DDP4 diabetes dipeptidyl peptidase docking score DPP4 drugs enzyme exhibited Favipiravir flavonoid flavonoids gastrointestinal tract hederagenin Human Hydroxychloroquine immune immunomodulatory activities in silico in vitro investigated involved kidney ligands metabolite molecular molecular docking Momordica Momordica dioica oleanolic acid plant predicted protease Proteases Protein quercetin RdRP receptor reflect Remdesivir reported RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 main protease significant interaction Spike protein the SARS-CoV-2 therapeutic viral entry viral proteases. [DOI] 10.1080/07391102.2020.1868340 PMC 바로가기 [Article Type] Article
Thrombosis and thrombocytopenia in COVID-19 and after COVID-19 vaccinationCOVID-19 및 COVID-19 백신 접종 후의 혈전증 및 혈소판 감소증Review Published on 2022-07-012022-09-11 Journal: Trends in cardiovascular medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive immune system Adenovirus Adenovirus-vectored vaccine administration aggregation angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antibody detection Antiplatelet factor cause Coagulation Coagulopathy condition coronavirus coronavirus disease COVID-19 COVID-19 vaccination Critical detect diagnosing Diagnosis Disease progression disease severity dysregulation effective ELISA enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay event false-positive rate false-positive rates hemophagocytic lymphohistiocytosis hemophagocytic syndrome immune Immune thrombocytopenic purpura Inflammation initial Interaction lupus erythematosus Messenger RNA mitigate occur optical optical density Pathogenesis PF4 Platelet platelet aggregation Platelets positive progression purpura SARS-CoV-2 serious complication severe acute respiratory syndrome Coronavirus Side effects Spike protein syndrome systemic lupus erythematosus the disease the patient thrombocytopenia thrombocytopenic purpura Thromboembolism thrombosis thrombotic Thrombotic thrombocytopenia Thrombotic thrombocytopenic purpura vaccination Vaccine vaccine. Vaccines vectored vaccine [DOI] 10.1016/j.tcm.2022.02.008 PMC 바로가기 [Article Type] Review
Effect of 17β-estradiol on the daily pattern of ACE2, ADAM17, TMPRSS2 and estradiol receptor transcription in the lungs and colon of male rats17β-estradiol이 수컷 쥐의 폐와 결장에서 ACE2, ADAM17, TMPRSS2 및 estradiol 수용체 전사의 일일 패턴에 미치는 영향Article Published on 2022-06-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol ACE2 ACE2 mRNA ADAM17 Administered administration amplitude analysed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Bmal1 Cell CLOCK Colon component components dosage Effect enzyme ESR1 ESR2 expression Features female GPER1 greater implicated lung Lungs male men molecules mRNA expression pathway pharmacological progression receptor Regulation Renin renin-angiotensin system rhythm sampling SARS-CoV-2 SARS-CoV-2 entry shown survival rate the SARS-CoV-2 the timing therapy tissue TMPRSS2 Transcription Treatment was performed women [DOI] 10.1371/journal.pone.0270609 PMC 바로가기 [Article Type] Article
Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronavirusesSARS-CoV, SARS-CoV-2 및 관련 코로나바이러스의 RBD에 대한 말 ACE2의 결합 및 구조적 기초Article Published on 2022-06-212022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin angiotensin converting enzyme binding binding affinity causative agent continuous surveillance coronavirus coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs crystal structure crystal structures enzyme equine events highlight host range humans infect Interaction Mutation N501Y omicron Prevent question RaTG13 RBD RBDs Receptor binding domain receptor binding domains residue SARS-CoV SARS-CoV-2 Surveillance target tested the binding affinity variant VOCs [DOI] 10.1038/s41467-022-31276-6 PMC 바로가기 [Article Type] Article
Glucocorticoids Bind to SARS-CoV-2 S1 at Multiple Sites Causing Cooperative Inhibition of SARS-CoV-2 S1 Interaction With ACE2글루코코르티코이드는 여러 부위에서 SARS-CoV-2 S1에 결합하여 ACE2와 SARS-CoV-2 S1 상호작용을 협력적으로 억제합니다Article Published on 2022-06-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-SARS-CoV-2 Asymptomatic Beta bind binding binding energy binding pocket binding pockets biochemical biochemically catalytic activity causing cellular receptor chimeric conformational state contributed Cooperative coronavirus cortisol COVID COVID-19 patients Delta Dexamethasone disrupt E484K enzyme Glucocorticoids indicated inhibition Innate immunity innate immunity. Interaction K417N Limited mass spectrometry mechanism Mild molecular molecular dynamics monoclonal antibody Multiple mutant mutated N501Y omicron Omicron variants Protein Receptor binding domain reduce mortality SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 SARS-CoV-2 spike Site variant without affecting [DOI] 10.3389/fimmu.2022.906687 PMC 바로가기 [Article Type] Article
Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vapingCOVID-19의 신경 전달 및 흡연 및 전자담배에 의한 신경염증 상태에서 성상교세포 안지오텐신 전환 효소 2의 잠재적 역할Article Published on 2022-06-072022-09-11 Journal: Fluids and Barriers of the CNS [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 expression affecting Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Astrocyte astrocytes Brain Cell cell type cells characterized Choroid plexus conducted COVID-19 COVID-19 patients COVID-19 severity cultured cells cytokine distribution domain endothelial cells entry receptor enzyme epithelial cell epithelial cells evaluate the effect exacerbate exacerbated expressed expression glial cell help highlight hypothalamus IL-5 IL-6 Immunocompromised immunohistochemistry immunomodulatory Inflammation manifestation marker Medulla oblongata meninges neural transmission Neurogenesis Neuron neurons Nicotine oblongata Pathogenesis pathogenesis of COVID-19 pericytes Post-infection Potential proinflammatory Real-time PCR responsible risk factor SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection shown significantly Smokers smoking smoking. stroma systemically third ventricle Transmission understanding ventricular were used western blot zone [DOI] 10.1186/s12987-022-00339-7 PMC 바로가기 [Article Type] Article
Cytoplasmic domain and enzymatic activity of ACE2 are not required for PI4KB dependent endocytosis entry of SARS-CoV-2 into host cellsSARS-CoV-2의 숙주 세포 내로의 PI4KB 의존성 세포내이입 진입에는 ACE2의 세포질 도메인 및 효소 활성이 필요하지 않습니다Article Published on 2022-06-012022-09-11 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 addition angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Angiotensin converting enzyme 2 (ACE2) catalytic activity causative agent Cell cellular cellular entry cellular receptor clathrin Clathrin-mediated endocytosis COVID-19 pandemic delta variant demonstrated dependent on domain effective endocytosis entry of SARS-CoV-2 enzymatic activity enzyme health emergency host cell host cells human angiotensin converting enzyme 2 infections intracellular domain lentivirus Phosphoinositides PI4KB predominant principle pseudotype required SARS-CoV-2 Spike protein syncytium syncytium formation Syncytium. treat variant viral entry virus entry [DOI] 10.1016/j.virs.2022.03.003 PMC 바로가기 [Article Type] Article
Ursodeoxycholic acid ameliorates cell migration retarded by the SARS-CoV-2 spike protein in BEAS-2B human bronchial epithelial cellsUrsodeoxycholic acid는 BEAS-2B 인간 기관지 상피 세포에서 SARS-CoV-2 스파이크 단백질에 의해 지연된 세포 이동을 개선합니다Article Published on 2022-06-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression airway analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 basal layer BEAS-2B Beas-2B bronchial epithelial cell BEAS-2B cell Beas-2B cells binding bronchial epithelial cell caused Cell Cell migration cell proliferation cells changes in conditions contribute control cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 damage damaged differentiation DNA ENhance enzyme epithelial epithelial cell flow cytometry followed by Gene Expression greater HEK293T Hela immunostaining inhibitory Interaction investigated mechanism Migration overexpression Plasmid Prevent Protective RBD receptor Receptor-binding domain reduced repair repair mechanism Repair mechanisms restoration restored RT-PCR SARS- CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein significantly Single Cell SP binding Spike protein syndrome the receptor-binding domain the SARS-CoV-2 the spike protein transfection Treatment Ursodeoxycholic acid Ursodeoxycholic acid (UDCA). virus infection was increased was measured western blotting wound healing [DOI] 10.1016/j.biopha.2022.113021 PMC 바로가기 [Article Type] Article
Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infectionSARS-CoV-2 감염과 관련된 유전자의 유전적 변이 및 임상 표현형과의 연관성에 대한 자연 선택의 영향Article Published on 2022-05-242022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, [키워드] 1000 Genomes Project ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive African African diversity Amino acid amino acid change analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 Antigen association caused clinical phenotype clinical phenotypes complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dipeptidyl peptidase Dipeptidyl peptidase 4 DPP4 Electronic health record Electronic health records enzyme European Genetic genetic diversity genetic variants Genetic variation Genome genomic Haplotype haplotypes Health host gene host genes Human identify Impact in some individual investigated involved Lineage locus LY6E lymphocyte minor allele frequency natural selection nonsynonymous variant pandemic patients with COVID-19 phenotype phenotype association. populations Positive selection protease Protein provide regulatory region SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2/COVID-19 Serine serine 2 severe acute respiratory syndrome Coronavirus target targets TMPRSS2 transmembrane transmembrane protease serine 2 variant Variation viral infections viruses [DOI] 10.1073/pnas.2123000119 PMC 바로가기 [Article Type] Article