Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 DeltaArticle Published on 2022-10-262022-11-15 Journal: BMC Complementary Medicine and Therapies [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Acetate activities Analysis Anti-viral anti-viral agents antioxidant antiviral activity Antiviral effect Asthma bacterial respiratory infections Bersama abyssinica bioactive compounds bronchitis BSL-3 component Compound Concentration conducted coronavirus Coviba Dawa COVID-19 COVID-19 symptoms cytotoxicity Delta delta variant determine ether experiment fraction in vitro ingredient Isolation level 3 medication methanol Phenols polar procedure propionate Registered respiratory disorder SARS-CoV-2 Screening Secondary Metabolite Standard Tanzania temperature tested the SARS-CoV-2 Traditional Traditional medicine treat VERO E6 cells viral pathogen virus was done was obtained water [DOI] 10.1186/s12906-022-03754-3 PMC 바로가기
Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue syndromeArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] analyzed Anti-viral anti-viral antibody antibody Antibody Response baseline chronic disease CMV cohorts COVID-19 EBV elevated fatigue healthy donor herpesvirus herpesvirus reactivation HERV HERV-K HHV6A HSV2 IgG immunoassay latent virus majority ME/CFS mechanisms multiplex Myalgic encephalomyelitis/chronic fatigue syndrome nuclear oral mucosa overlap Patient plasma Post-viral fatigue Reactivation retrovirus risk factor Saliva SARS-COV-2 infection shown significantly sustained Symptom syndrome systemically triggered unique viral infection virus [DOI] 10.3389/fimmu.2022.949787 PMC 바로가기
Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Alpha Altered Anti-viral Anti-viral therapy Antiviral assays biological molecules cathepsin L Cell cell entry cellular proteases cleaved designer serpin effective enzyme expressing facilitate furin generate host cell protease implicated in vitro infection with SARS-CoV-2 inhibit inhibition inhibitor inhibitors inhibitory inhibitory activity loop membrane fusion Mutagenesis P681R predicted produced protease Protein purified rate constant reactive Recombinant protein S protein cleavage S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral replication SARS-CoV-2 virus serine 2 serine protease inhibitor SerpinB3 shown specificity suppress target the Spike the spike protein TMPRSS2 transmembrane variant Vero E6 cell [DOI] 10.3390/ijms232012522 PMC 바로가기
Derivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 MPro, SPro, and RdRp: A Pharmacological PerspectiveArticle Published on 2022-10-172022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] (S)-Goniothalamin Anti-viral anticancer antioxidant antiviral properties antiviral property approach characterization complex Compound coronavirus COVID-19 derivation derivative disease drug examined LC-MS molecular molecular dynamics MPro NMR pandemic performed phytochemical platform Pro RdRP required Research SARS-CoV-2 SARS-COV-2 infection Simulation study spike glycoprotein target target protein threat [DOI] 10.3390/molecules27206962 PMC 바로가기
Design, Synthesis and In Vitro Evaluation of Spirooxindole-Based Phenylsulfonyl Moiety as a Candidate Anti-SAR-CoV-2 and MERS-CoV-2 with the Implementation of Combination StudiesArticle Published on 2022-10-062022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] accompanied ADMET anti-coronavirus activity anti-SARS-CoV-2 anti-SARS-CoV-2 therapeutics Anti-viral antiviral activity approach binding candidate Combination Community Compound COVID-19 drug combination drug combination protocol effective highlight highly pathogenic human coronavirus in silico inhibit investigated MD simulation MERS-CoV moiety molecular molecular dynamic simulation (MDS) pharmacophores protocol protocols reaction Research SARS-CoV-2 spirooxindole. synergistic synthesis tested were assessed [DOI] 10.3390/ijms231911861 PMC 바로가기
Immunogenicity, Safety, and Anti-Viral Efficacy of a Subunit SARS-CoV-2 Vaccine Candidate in Captive Black-Footed Ferrets ( Mustela nigripes) and Their Susceptibility to Viral ChallengeArticle Published on 2022-10-042022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Affect Anti-viral Antibody Response Antibody titer black-footed ferrets candidate challenge clinical disease correlated declined Efficacy experimental challenge ferret highest Human immunogenicity in vitro in vivo increase in indicate lack lung viral load mice morbidity Mortality mustelids pathogen populations potential risk pre-vaccination produced Protein purified Safety SARS-CoV-2 SARS-CoV-2 S1 serum subunit susceptibility transfer Trial unlikely upper respiratory tract vaccination vaccinees viral replication was determined [DOI] 10.3390/v14102188 PMC 바로가기
Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phytochemical & pharmacological perspectiveReview article Published on 2022-10-012022-10-05 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] Administered anti-bacterial Anti-inflammatory Anti-viral articles Ayurveda caused classical co-morbidities co-morbidity Complication complications Cordia coronavirus disease-2019 COVID-19 COVID-19 incidence develop drug Effect effective Efficacy English Government of India gut microbiota healthy help Home isolation Homeopathy Influenza influenza viruses information ingredient Joshānda mechanism Medicine mild patient mitigate morbidity and mortality observation Occurrence offer organ pathological change Perspective pharmacological physiological functions phytochemical Prevent Prophylactic proportion Protective reduce Regulation Research respiratory respiratory infections respiratory tract respiratory viral respiratory viral infection respiratory viral infections searched self-care severe disease Siddha the disease therapeutic therapeutic activity therapeutic benefits Unani decoction website were excluded yoga [DOI] 10.1016/j.jep.2022.115526 [Article Type] Review article
Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulationsArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] absence acting acute respiratory syndrome Amino acid Analysis Anti-viral binding site catalytic coronavirus disease Coronavirus-2 COVID-19 distribution docking score effective Entry inhibitor glycoprotein host cell in silico inhibitor Interaction less Ligand MD simulation MD simulations medications metabolism molecular molecular docking nucleic acid offered performed Precision research finding residue SARS CoV-2 spike spike glycoprotein stability starting point target Toxicity viral entry Virtual screening [DOI] 10.1007/s11030-022-10394-9 PMC 바로가기
Evaluation of the efficacy of oral nano-silymarin formulation in hospitalized patients with COVID-19: A double-blind placebo-controlled clinical trialArticle Published on 2022-10-012022-11-15 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] alanine aminotransferase Anti-viral Antiviral assigned baseline clinical trial Concomitant COVID-19 cytokine release Cytokine release syndrome Dexamethasone dosage double-blind Effect effective Effectiveness Efficacy Evidence follow-up period gel Hospitalization hospitalized patient Laboratory Laboratory parameters lack liver enzyme management outbreak pandemic participant Patient patients with COVID-19 placebo group placebo-controlled clinical trial receiving Remdesivir sample sizes SARS-CoV-2 significant difference significantly silymarin Symptom the placebo group therapeutic strategy Treatment treatment group two group viral disease were assessed [DOI] 10.1002/ptr.7537 PMC 바로가기
Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-viralsArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 binding affinity angiotensin-converting enzyme 2 Anti-viral antivirals binding biosynthetic build candidate Cell D614G mutation displaying dissemination EC50 EC50 value fusion protein generate hamsters high stability in vitro Infection Interaction mitigate motif nasal nasal epithelium neutralisation activity neutralization neutralized Omicron variants overlapping promote Protein protein sequence proximal RBD Receptor binding domain recognizing reduced Replication SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants selected targeting the RBD the SARS-CoV-2 trivalent virus virus entry [DOI] 10.1371/journal.ppat.1010799 PMC 바로가기