Avidity in antibody effector functions and biotherapeutic drug design Reviews Published on 2022-07-052022-10-05 Journal: Nature Reviews Drug Discovery [Category] 변종, 유전자 메커니즘, 치료제, [키워드] accumulated Adaptive immune response affinity antibody Antibody avidity avidity binding Biotherapeutics cellular disease-causing Diseases drug drug design drugs effector molecule Efficacy function functional functions humoral immune system Interaction invading pathogen mechanism Neutralizing polyclonal response review therapeutic Treatment variety [DOI] 10.1038/s41573-022-00501-8 [Article Type] Reviews
Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis항-CD20 치료 다발성 경화증에서 SARS-CoV-2에 대한 보존된 T 세포 반응Article Published on 2022-06-012022-09-11 Journal: Multiple sclerosis (Houndmills, Basingstoke, Engla [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-CD20 anti-CD20 therapy anti-SARS-CoV-2 anti-SARS-CoV-2 spike protein antibodies Antibody avidity avidity CD20 Cellular immune response Cohort Coronavirus-2 detectable healthy control healthy controls humoral Humoral and cellular immune responses IgA IgG IgG level IgG levels immune responses Immunoglobulin Immunoglobulin G infected with SARS-CoV-2 management Multiple multiple sclerosis neutralizing capacity occurred pandemic Patient respiratory SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 IgG SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike protein SARS-CoV-2 vaccination SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells second vaccination Spike protein T cell response T cells treated Treatment vaccination Vaccinations virus were measured [DOI] 10.1177/13524585221094478 PMC 바로가기 [Article Type] Article
Characterizing Kinetics and Avidity of SARS-CoV-2 Antibody Responses in COVID-19 Greek PatientsCOVID-19 그리스 환자에서 SARS-CoV-2 항체 반응의 동력학 및 결합력 특성화Article Published on 2022-04-052022-09-12 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy analyzed antibody Antibody avidity antibody avidity. antibody level avidity Clinical symptoms Concentration Course COVID-19 COVID-19 patient defined determine Diagnosis examined Hospitalized hospitalized patient IgG IgG kinetics immune response Immunity IMPROVE in both group Infection infections Kinetics maturation men overcome Patient Reinfection response risk SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection serological Sex significantly Variability women [DOI] 10.3390/v14040758 PMC 바로가기 [Article Type] Article
Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance돌연변이 저항성이 높은 SARS-CoV-2에 대한 초강력 중화항체Research Article Published on 2022-02-152022-09-10 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibodies antibody Antibody avidity Betacoronavirus binding blocking cell entry cell entry complex COVID-19 crystal structure Drug screens drug therapy eliminating expressing F486 functional hotspot IgG mechanism mutant mutant viruses Mutation NAb NAbs neutralization Neutralizing antibodies neutralizing antibody Pharmacology potency profile RBD RBDs Receptor binding domain residue SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody screened Spike protein susceptible the RBD the spike protein underlie unique variants variants of concern Viral viral escape Virus neutralization yeast [DOI] 10.1172/JCI154987 PMC 바로가기 [Article Type] Research Article
Poor neutralization and rapid decay of antibodies to SARS-CoV-2 variants in vaccinated dialysis patientsResearch Article Published on 2022-02-102022-10-28 Journal: PLoS ONE [Category] COVID-19, COVID19(2023년), SARS, [키워드] antibody Antibody avidity Antibody Response average BNT162b2 correlated Course Coverage COVID-19 delta variant dialysis dose fraction Hemodialysis IgG antibody immunized Intervention mRNA-1273 mRNA-1273 vaccines neutralization Neutralizing activity neutralizing antibody non-responder of BNT162b2 Patient patients Peritoneal dialysis plasma sample Poor Prophylactic reduced reduction required risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike the antibody response the patient therapeutic therapeutic strategy understanding undetectable vaccination variants [DOI] 10.1371/journal.pone.0263328 PMC 바로가기 [Article Type] Research Article
Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers노출되고 순진한 의료 종사자 집단에서 COVID-19 mRNA 백신에 대한 초기 항체 반응의 결정 요인Clinical Trial Published on 2022-01-012022-09-11 Journal: EBioMedicine [Category] 변종, 임상, 진단, 치료기술, 치료법, [키워드] 95% CI Adults adverse events Affect allergy Alpha Analysis analyzed antibody Antibody avidity antibody levels Antibody Response Antigen antigens avidity Barcelona Beta BNT162b2 brand center Cohort Comorbidities Comorbidity COVID-19 COVID-19 mRNA vaccine Daniel Data collection days post-infection decision determinant development dose Effectiveness Efficacy European evaluated expected Factor Gamma had no Health care Health care worker health care workers healthcare worker healthy individual heterogeneity IgA IgG IgG and IgM IgG level IgG levels Immunity indicate Infectious disease Infectious diseases Influenza Innovation maintenance manuscript Moderna mRNA mRNA vaccination mRNA vaccines mRNA-1273 naïve neutralization neutralization capacity neutralizing capacity nucleocapsid omicron Pfizer/BioNTech preparation Program reagent receiving recommendation respond response responsiveness robust SARS-CoV-2 SARS-CoV-2 spike Science second dose seropositive Severo Ochoa shown Single-dose smoking Spanish state Study design Support supported symptomatic systemic adverse effect systemic adverse effects technology the preparation union vaccination vaccine doses vaccinees variant variants variants of concern wild-type [DOI] 10.1016/j.ebiom.2021.103805 PMC 바로가기 [Article Type] Clinical Trial
Antibody response to SARS-CoV-2 for more than one year – kinetics and persistence of detection are predominantly determined by avidity progression and test design1년 이상 SARS-CoV-2에 대한 항체 반응 - 검출의 동역학 및 지속성은 주로 결합력 진행 및 테스트 설계에 의해 결정됩니다.Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 진단, 치료기술, 치료제, [키워드] anti-SARS-CoV-2 antibody Antibody avidity Antibody detection Antibody Response Antigen correlated correlation Course COVID-19 COVID-19 severity determined by dropped Efficiency evaluated except for heterogeneous highest IgA IgG IgM Mild neutralization neutralizing antibody Patient persistence Persistence SARS-CoV-2 antibodies positive progression provided RBD remained SARS-CoV-2 sensitivity severe COVID-19 significantly specificity symptom onset Testing Variation was determined [DOI] 10.1016/j.jcv.2021.105052 PMC 바로가기 [Article Type] Article
Humoral response to spike S1 and S2 and nucleocapsid proteins on microarray after SARS-CoV-2 infectionSARS-CoV-2 감염 후 마이크로어레이의 스파이크 S1 및 S2 및 뉴클레오캡시드 단백질에 대한 체액 반응Article Published on 2022-01-012022-09-11 Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-S1 anti-S2 antibody Antibody avidity Antibody Response Antigen Asymptomatic clinical evolution Comorbidities coronavirus coronavirus disease Coronavirus disease 2019 coronavirus disease 2019) COVID-19 Deceased disease severity dynamic evaluated functional groups humoral immune response Humoral response IgA IgG IgG antibodies IgG response median Microarray Mild moderate natural infection not differ nucleocapsid nucleocapsid protein Nucleocapsid proteins observation positive correlation presence of comorbidities Protein quantification respiratory response S1 and S2 SARS-CoV-2 SARS-COV-2 infection Seroconversion seroreversion serum sample serum samples severe acute respiratory syndrome Coronavirus severe coronavirus disease significantly spike subunit subunits Test ViraChip® Viral Viral RNA Volunteer volunteers [DOI] 10.1002/jmv.27290 PMC 바로가기 [Article Type] Article
Efficacy of anti-SARS-CoV-2 mRNA vaccine in systemic autoimmune disorders: induction of high avidity and neutralising anti-RBD antibodies전신 자가면역 질환에서 항 SARS-CoV-2 mRNA 백신의 효능: 높은 결합력 유도 및 항-RBD 항체 중화Article Published on 2021-12-012022-09-11 Journal: RMD Open [Category] SARS, 진단, 치료기술, [키워드] abatacept ACE2 Anti-RBD antibodies Anti-RBD antibody Anti-RBD IgG anti-SARS-CoV-2 antibodies Antibody avidity Autoimmune Autoimmune diseases boost control group controls COVID-19 detectable disorder domain elicited ELISA evaluate evaluated first dose healthcare worker healthy control healthy controls IgA IgA antibodies IgA antibody IgG IgG antibodies IgG antibody IgM immune response inhibiting Interaction mRNA vaccine mycophenolate neutralising Neutralising activity Neutralising Antibodies no effect not significantly different Patient patients produced RBD RBD IgG SARS-CoV-2 the patient therapy These data titre urea vaccination was tested were measured [DOI] 10.1136/rmdopen-2021-001914 PMC 바로가기 [Article Type] Article
Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 항체 결합력 성숙도 및 질병 중증도와의 연관성의 동역학Article Published on 2021-11-022022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody Antibody avidity avidity coronavirus coronavirus 2 correlation COVID-19 disease IgG immunoassay Infection Kinetics label-free immunoassay maturation Mild peak respiratory SARS-CoV-2 significantly higher symptom onset thin-film interferometry. [DOI] 10.1093/cid/ciaa1389 PMC 바로가기 [Article Type] Article