Targeting of nucleoprotein to chemokine receptors by DNA vaccination results in increased CD8(+)-mediated cross protection against influenzaArticle Published on 2015-12-082023-06-25 Journal: Vaccine [Category] 신종인플루엔자, [키워드] antigen presenting cells APC-targeting cytotoxic DNA vaccine Influenza nucleoprotein T cells vaccine. [DOI] 10.1016/j.vaccine.2015.08.094 PMC 바로가기
How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review세포 사멸 β 세포가 내성 또는 자가 면역 당뇨병에 대한 면역 반응을 지시하는 방법: 리뷰Original Paper Published on 2015-01-222022-08-07 Journal: Apoptosis [Category] Biochemistry, [키워드] β-Cells Activation antigen presenting cell antigen presenting cells APCS Apoptosis apoptotic cell clearance apoptotic cells apoptotic β-cell autoantigen Autoantigens Autoimmune autoimmune attack autoimmune diabetes Autoimmune disease Autoimmune diseases Autoimmunity Cell contribute contributing to dendritic cells diabetes Effect Efferocytosis endogenous insulin secretion immune response immune tolerance immunological tolerance immunotherapies Immunotherapy increase in induce Inflammation insulin insulin-producing β-cell insulin-producing β-cells long-term tolerance maintenance maturation mechanism medical health challenge metabolic disease pancreatic islet pancreatic islets pancreatic islets of Langerhans Patient physiological mechanism Research self T1D target cell target cells therapy Tolerance tolerance to self translational Treatment Type 1 diabete Type 1 diabetes β-cell β-cells [DOI] 10.1007/s10495-015-1090-8 PMC 바로가기 [Article Type] Original Paper
Identification of Orch3 , a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C자가면역 고환염에 대한 지배적인 내성을 제어하는 유전자좌인 Orch3의 확인, 키네신 계열 구성원 1CResearch Article Published on 2012-12-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major adjuvants allele alleles animal model Antigen antigen presenting cell antigen presenting cells approach Author Autoimmune Autoimmune disease autoimmune disease susceptibility Autoimmune diseases Autoimmunity autologous characterization chromosome chromosome 11 controlling demonstrated disease disease susceptibility dominant encodes gene etiology exhibiting expression family family member Gene Genetic genetic determinant Genetic predisposition Genome histocompatibility complex identification immunization individual gene individual genes inflammatory disease Kif1c KIF21B KIF5A Kinesin leads loci locus major histocompatibility complex mapped member MHC MHC class MHC class II mice non-infectious orchitis over-expression polymorphism Polymorphisms proliferative Quantitative quantitative trait locus reduced required resistance resistant allele strain susceptibility susceptible T cell T cell responses transcriptional regulation transgenic variety [DOI] 10.1371/journal.pgen.1003140 PMC 바로가기 [Article Type] Research Article