Antimicrobial therapy – Page 2 – Communicable Diseases Research

Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial

Research

Published on 2022-02-282022-11-01
Journal: Critical Care [Category] COVID-19,

The changing pattern of bacterial and fungal respiratory isolates in patients with and without COVID-19 admitted to intensive care unit

Observational Study

Published on 2022-02-232022-10-04
Journal: BMC Infectious Diseases [Category] COVID19(2023년), Fulltext, MERS, SARS, 임상,

[키워드] acute respiratory syndrome antibiotic Antimicrobial therapy Bacteria Bacterial BAL Bronchoalveolar lavage carbapenem collected Complete conducted contrary COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 positive patient Effect Enterococcus evaluate First wave fungal gram Haemophilus influenzae hospital Hospitalization Hospitalized ICU ICUs increase in Intensive intensive care intensive care unit isolate isolates Italy national health system Nurse objective observé pandemic Patient patients with COVID-19 patients without COVID-19 Period Personal protective equipment positive Prevalence profile protocol Pseudomona reduction Result retrospective SARS-CoV-2 statistically significant Streptococcus pneumoniae Surveillance tertiary referral hospital tracheal
[DOI] 10.1186/s12879-022-07176-x PMC 바로가기 [Article Type] Observational Study

Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19

개별화 항생제 치료를 위한 프로칼시토닌: COVID-19에 초점을 맞춘 업데이트

Review

Published on 2022-01-012022-09-11
Journal: Critical reviews in clinical laboratory sciences [Category] SARS, 바이오마커,

[키워드] antibiotic Antibiotics antimicrobial antimicrobial resistance Antimicrobial stewardship Antimicrobial therapy available data Bacterial infection benefit Biomarker Biomarkers can be used Care Clinical data clinical outcomes clinical setting coronavirus disease Coronavirus disease 2019 COVID-19 determine Diseases Evidence Health Organization heterogeneous implication IMPROVE key consideration leads limit Patient patients with COVID-19 PCT Probability procalcitonin prognostic protocols provide randomized trials reducing reductions reductions in respiratory respiratory infection respiratory infections respiratory tract infection Respiratory tract infections Sepsis severity shown Still therapy Trial trials use of antibiotics Viral World Health Organization
[DOI] 10.1080/10408363.2021.1975637 PMC 바로가기 [Article Type] Review

A Metabolomics approach for the diagnosis Of SecondAry InfeCtions in COVID-19 (MOSAIC): a study protocol

Observational Study

Published on 2021-12-022022-10-04
Journal: BMC Infectious Diseases [Category] SARS, 임상,

Diagnosis and Treatment of Bacterial Pneumonia in Critically Ill Patients with COVID-19 Using a Multiplex PCR Assay: A Large Italian Hospital’s Five-Month Experience

다중 PCR 분석을 사용한 COVID-19 중증 환자의 세균성 폐렴 진단 및 치료: 이탈리아 대형 병원의 5개월 경험

Research Article

Published on 2021-11-102022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 치료기술, 치료제,

[키워드] Acinetobacter Administered antibiotic Antibiotics antimicrobial antimicrobial resistance antimicrobial susceptibility Antimicrobial therapy AST Bacterial bacterial pneumonia caused change clinician Clinicians colistin collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient Culture Diagnosis diagnostics Effectiveness etiology experience FilmArray panel Gain ICU ICU patient ICU Patients Ill implementation initiated intensive care intensive care unit Italian Laboratory lead management mechanically ventilated nonpneumonia organism Organisms pathogen Patient patient treatment PCR PCR assay Pneumonia positive Pseudomonas aeruginosa resistance gene respiratory Respiratory samples risk Standard-of-care Staphylococcus aureus susceptibility suspicion tested Topic treated patients Treatment with COVID-19
[DOI] 10.1128/Spectrum.00695-21 PMC 바로가기 [Article Type] Research Article

341. Evaluation of Antimicrobial Use and Prescribing Patterns During the COVID-19 Pandemic in Patients Receiving Tocilizumab

Poster Abstracts

Published on 2021-11-042022-10-29
Journal: Open Forum Infectious Diseases [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis Antibiotics Antifungal antimicrobial Antimicrobial therapy Antimicrobials appear approved carbapenem categorical data cephalosporins Chi-square Continuous data control group control patient coronavirus disease Coronavirus-2 Coverage COVID-19 Critically ill patient cytokine release Cytokine storm distress evaluated higher odd highest hospital Hospital stay in both groups increased risk infected patient Infection institutional review board IQR Mann-Whitney test median Mortality outcome outcomes Patient pattern positive prescribing primary endpoint reported required Result retrospective SARS-CoV-2 secondary endpoint Secondary infection serious infections systemic inflammation therapy Tocilizumab tocilizumab patient treat Treatment treatment group was used
[DOI] 10.1093/ofid/ofab466.542 PMC 바로가기 [Article Type] Poster Abstracts

Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction

헴 옥시게나제-1 유도를 통한 코로나19 치료의 새로운 후보인 헤민

Article

Published on 2021-11-022022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antimicrobial therapy antiviral activity Antiviral effect antiviral effects Biliverdin byproduct causative agent cells coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death rate effective enzyme expression expression vector Free growth heme hemin in vitro inducer Inflammatory response inhibit investigated iron oxidative stress Protein reduce reported respiratory restrict Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selectivity index severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggested suppresse suppressed therapeutic transient expression treating COVID-19 Treatment Viral viral infection viral infections virus
[DOI] 10.1038/s41598-021-01054-3 PMC 바로가기 [Article Type] Article

Development of a physiological model of human middle ear epithelium

Original Research

Published on 2021-09-182022-10-30
Journal: The Laryngoscope [Category] COVID-19,

[키워드] acute infection Antimicrobial therapy Biological models cells changed children ciliated clinical implication complex conditions Culture develop development disease Diseases epithelial epithelial cell epithelial cell type goblet immunofluorescence immunohistochemistry in vivo lack Level media membrane Microscopy mucosal otitis otitis media otorhinolaryngologic diseases physiological polymerase chain positive reflect Research respiratory mucosa Result Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 shown subtype susceptible the healthy translational transmission electron microscopy Treatment undergo Ventilated
[DOI] 10.1002/lio2.661 PMC 바로가기 [Article Type] Original Research

Treatment of moderate to severe respiratory COVID-19: a cost-utility analysis

Article

Published on 2021-09-072022-10-04
Journal: Scientific Reports [Category] SARS, 임상, 치료법, 치료제,

[키워드] adjusted Analysis Antimicrobial therapy calculated Care costly COVID-19 COVID-19 infection Critical Dexamethasone effective Health Health care economics healthcare hospital hospitalized patient Infectious diseases intensive care intubation less moderate moderate-severe morbidity and mortality oxygen Patient patients Perspective pharmacologic treatment Remdesivir required resource respiratory infection Respiratory tract diseases sensitivity analysis severe COVID-19 severe infections severity short duration Strategy Support supportive care the United State treatment for COVID-19 unlikely was performed with COVID-19
[DOI] 10.1038/s41598-021-97259-7 PMC 바로가기 [Article Type] Article

High-titre convalescent plasma therapy for an immunocompromised patient with systemic lupus erythematosus with protracted SARS-CoV-2 infection

장기간의 SARS-CoV-2 감염을 동반한 전신성 홍반성 루푸스가 있는 면역저하 환자를 위한 고역가 회복기 혈장 요법

Case Reports

Published on 2021-08-252022-09-11
Journal: BMJ case reports [Category] SARS, 치료기술,

[키워드] Administered anti-CD20 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antimicrobial therapy Biological agents Bronchoalveolar lavage cell cultures Clinical improvement convalescent plasma Convalescent plasma therapy Corticosteroid COVID-19 COVID-19 pneumonia Dexamethasone High-dose hospital hypoxaemia Immunocompromised Immunocompromised patient lung opacities lupus erythematosus monoclonal antibody opportunistic infection opportunistic Infections PCR Pneumonia positive receiving Respiratory system reverse transcription PCR rituximab SARS-CoV-2 SARS-COV-2 infection symptom onset systemic lupus erythematosus Transcription treated Treatment virus replication with COVID-19
[DOI] 10.1136/bcr-2021-244853 PMC 바로가기 [Article Type] Case Reports