Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[ n]urilsArticle Published on 2022-10-142022-11-15 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 치료제, [키워드] acting amino acids Antiviral Antiviral compound Antiviral effect antivirals Cell Compound compounds Contact cucurbituril disease dose−response Efficacy Extracellular herpes simplex homologue Interaction investigated macrocycle mechanism morbidity Mortality nontoxic pathogen property Protein respiratory syncytial virus responsible RSV SARS-CoV-2 viral surface virucidal virus viruses virustatic. [DOI] 10.1021/acsinfecdis.2c00186 PMC 바로가기
Optimized parameters for effective SARS-CoV-2 inactivation using UVC-LED at 275 nmArticle Published on 2022-10-052022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral effect Community contribute coronavirus disease COVID-19 dose effective feature healthcare inactivation intensity investigated irradiation less medications new treatment strategy pandemic parameter Prevent reduce reduction SARS-CoV-2 SARS-COV-2 infection severity Spread temperature Vaccines viral mutation Viral transmission [DOI] 10.1038/s41598-022-20813-4 PMC 바로가기
Ginkgo biloba in the management of the COVID-19 severityArticle Published on 2022-10-012022-11-15 Journal: Archiv der Pharmazie [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute lung injury acute respiratory distress acute respiratory syndrome aggregation alleviate Anti-inflammatory antioxidant Antiviral Antiviral effect attenuate booster complementary complementary medicine complications coronavirus disease Coronavirus-2 COVID-19 COVID-19 severity Critical drug Effect Effectiveness extreme Ginkgo Ginkgo biloba impede Infection inflammatory disorder management mechanisms nanomedicines Neutrophil elastase offer oxidative stress Platelet proinflammatory cytokines protease Proteases provide SARS-CoV-2 symptomatic syndrome therapy thrombosis viral proteases [DOI] 10.1002/ardp.202200188 PMC 바로가기
Effects of Boswellia species on viral infections with particular attention to SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료제, [키워드] activity antiviral activity antiviral drugs Antiviral effect antiviral property Boswellia Boswellia species bronchial asthma caused condition COVID-19 pandemic disease drugs Effect Efficacy exhibited Herbal herbal medicine natural Natural therapies pathogenic virus pharmacological plants provided reduction in reported Research SARS-CoV-2 therapeutic effect Topic Treatment Vaccine Viral diseases viral infection Viral resistance [DOI] 10.1007/s10787-022-01037-4 PMC 바로가기
Randomized clinical trial of nitazoxanide or sofosbuvir/daclatasvir for the prevention of SARS-CoV-2 infectionArticle Published on 2022-09-302022-11-15 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 치료제, [키워드] 95% CI adverse event antibody Antiviral effect ARMS clinical trial clinical trials control arm COVID-19 infection COVID-19 symptom criteria enrolled evaluated experimental arm Frequency had no healthcare worker high risk in vitro incidence rate Infection infection with SARS-CoV-2 nitazoxanide no significant difference participant PCR testing Poisson regression model positive SARS-CoV-2 PCR primary endpoint randomization Randomized randomized trial risk safety analysis SARS-CoV-2 SARS-COV-2 infection serology shown sofosbuvir/daclatasvir South Africa Symptoms the primary endpoint Treatment Trial was selected was used [DOI] 10.1093/jac/dkac266 PMC 바로가기
A single-administration therapeutic interfering particle reduces SARS-CoV-2 viral shedding and pathogenesis in hamstersArticle Published on 2022-09-272022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome Administered Antiviral effect coronavirus COVID-19 pandemic delta variant Detection limit disease dose effective Efficacy exhibited hamster hamsters highest Infectious virus Inflammatory cytokines Intervention intranasally intrinsically limit Lipid nanoparticle Lower mucosa nasal Particle Pathogenesis Postinfection Prevent reduce reduced reported respiratory tissue respiratory virus SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 transmission SARS-CoV-2 viral shedding severe disease severe lung pathology significantly lower suppress tested therapeutic therapeutic interfering particles TIP tissue Transmissibility Transmission uninfected variants viral loads viral replication while [DOI] 10.1073/pnas.2204624119 PMC 바로가기
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenalReview Published on 2022-09-062022-10-04 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, [키워드] 3CLpro 3CLpro inhibitors accelerated ACE-2 ACE2 antibody anticipated Antiviral effect approach benefit composed Conjugates conserved Coronaviruses COVID-19 COVID-19 pandemic COVID19 drug Drug discovery effort Evidence FDA approval In-vitro inhibitor Medicinal chemistry monoclonal antibodies peptide-based peptides plethora PLPro PLpro inhibitors Predictive model Prevent Proteases Protein pursuit RdRP RdRp inhibitors Replication reported required researcher S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants small molecule small molecule drug Small molecule inhibitors targets therapeutic option TMPRSS2 TMPRSS2 drug repurposing TMPRSS2 inhibitors Treatment vaccination vaccine platform Vaccines viral entry viral replication [DOI] 10.1186/s12929-022-00847-6 PMC 바로가기 [Article Type] Review
Antiviral Activity of N1,N3-Disubstituted Uracil Derivatives against SARS-CoV-2 Variants of ConcernArticle Published on 2022-09-052022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 치료제, [키워드] activity addition antibody-based therapy Antiviral Antiviral agents antiviral drug Antiviral effect circulating circulating SARS-CoV-2 variants circulation Compound concern COVID-19 COVID-19 vaccines derivative effective Effectiveness infected with SARS-CoV-2 inhibit inhibitor non-nucleoside inhibitor. omicron Patient raise RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp significant decrease these compound Treatment uracil Variability variants of concern Vero E6 cell VoC VOCs widespread [DOI] 10.3390/ijms231710171 PMC 바로가기
A potent virucidal activity of functionalized TiO2 nanoparticles adsorbed with flavonoids against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Applied Microbiology and Biotechnology [Category] SARS, 치료제, [키워드] ACE-2 ACE-2 receptor Adsorption angiotensin-converting enzyme-2 Anti-SARS-CoV-2 Activity antiviral activity Antiviral effect antivirals binding block caused Cell Cell culture cell entry coronavirus SARS-CoV-2 COVID-19 Critical death demonstrated develop displaying Effect event Flavanone-7-O-glucoside flavonoid HCoV 229E Hesperetin-7-rutinoside host cell impair impairing imperative in vitro induce interact Interaction interfere management mechanism mental health molecular docking analysis Nanoparticulate compound pandemic receptor Region SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike glycoprotein. spike glycoprotein Spread supportive care targeted therapy the SARS-CoV-2 viral infection virucidal [DOI] 10.1007/s00253-022-12112-9 PMC 바로가기
Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2SARS-CoV-2 Omicron subvariants, BA.1 및 BA.2에 대한 중화 항체 및 항바이러스 약물의 다양한 효능Article Published on 2022-09-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Analysis antibodies antibody Antiviral antiviral drug antiviral drugs Antiviral effect antiviral effects BA.1 BA.2 Casirivimab Cell culture concentrations conserved coronavirus Delta drug treatment Efficacy EIDD-1931 Evidence FIVE Gamma Imdevimab Infection intrinsic mathematical molnupiravir Neutralizing antibodies neutralizing antibody Nirmatrelvir omicron other variant other variants quantified replacing respiratory SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus Sotrovimab Spread Treatment variant variants Viral [DOI] 10.1016/j.antiviral.2022.105372 PMC 바로가기 [Article Type] Article