antiviral immune responses – Page 2 – Communicable Diseases Research

Long Noncoding RNAs as Emerging Regulators of COVID-19

COVID-19의 새로운 조절자로서의 긴 비코딩 RNA

Review

Published on 2021-08-022022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료제,

Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection

염증의 내인성 조절은 무증상 또는 무증상 SARS-CoV-2 감염이 있는 임산부의 특징입니다.

Article

Published on 2021-07-292022-09-10
Journal: Nature Communications [Category] SARS, 바이오마커,

[키워드] Activation Affect alteration anti-inflammatory cytokine anti-inflammatory cytokines antiviral immune response antiviral immune responses Asymptomatic Blood cells cell proliferation cytokine cytokine production Cytokines cytometry analysis D-dimer damages develop differentiation during pregnancy endogenous help heterogenous IL-10 IL-17 IL-6 Immune cell immune responses immunological change immunological changes increase in Inflammation Inflammatory interleukin lymphopenia marker mild SARS-CoV-2 infection mother neutrophil Neutrophils PD-L1 Peripheral blood plasma Plasma levels Pregnancy pregnant women preserved pro-inflammatory cytokines remain unchanged reported SARS-COV-2 infection Therapeutic strategies therapeutic strategy therapeutic target Translational immunology viral infection virus White blood cells
[DOI] 10.1038/s41467-021-24940-w PMC 바로가기 [Article Type] Article

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2

인터페론-무기 RBD 이량 체는 SARS-COV-2에 대한 멸균 면역을위한 RBD의 면역 원성을 향상시킨다.

Clinical Trial

Published on 2021-07-152022-08-13
Journal: Cell Research [Category] Fulltext, SARS, 비임상, 임상, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjuvant Adults antigen processing antiviral immune responses appear Biological techniques breath caused Complete coronavirus COVID-19 dimerized DLNs draining lymph node effort elicit ENhance healthy High-dose human I-P-R-F vaccine I-P-R-F I-R-F immune responses Immunity Immunoglobulin induce initiated Innate immunity interferon long-lasting long-lasting neutralizing antibodies long-lasting neutralizing antibody low dose Lower respiratory tract lymph nodes NAbs overcome placebo-controlled protective immunity provide Randomized RBD RBD dimer Receptor-binding domain respiratory rhesus macaques Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell response the receptor-binding domain the vaccine Trial Trigger upper and lower respiratory tracts V-01 vaccination Vaccine vaccine candidate
[DOI] 10.1038/s41422-021-00531-8 PMC 바로가기 [Article Type] Clinical Trial

Innate immune sensing of coronavirus and viral evasion strategies

Review Article

Published on 2021-05-062022-10-31
Journal: Experimental & Molecular Medicine [Category] COVID-19, SARS,

[키워드] activated acute respiratory syndrome animal hosts Antiviral antiviral immune responses approach caused cellular receptor components coronavirus Coronavirus infections coronavirus protein Coronaviruses COVID-19 Critical cytokine Defense evade function Health Host host immune responses host immunity Human illnesses immune evasion immune sensing immune system Improved Infection infections Innate innate immune response innate immune system interferons (IFNs Invasion Japan knowledge mechanism MERS Middle East Mortality Mutation Organisms pathogen patients Pattern recognition receptors positive-sense receptor respond response resulting RNA virus SARS-CoV-2 single-stranded suppress syndrome Therapeutic approach TLR pathway TLR7 TLR7 gene Transmission triggered understanding university virus viruses zoonotic
[DOI] 10.1038/s12276-021-00602-1 PMC 바로가기 [Article Type] Review Article

From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis

Review Article

Published on 2021-04-162022-10-31
Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS,

Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection

Mini‐Review|Clinical

Published on 2021-03-222022-10-31
Journal: European Journal of Immunology [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome Affect antiviral immune responses antiviral responses association Baricitinib cellular entry receptor chemokine coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients Critically ill cytokine cytokine signaling Cytokine storm develop disease drug Effect endothelial cells epithelial explain Genetic polymorphism granulocyte help IFN IFN‐γ IL‐6 immunological Infection Inflammation inflammatory mediator initial interferon Jak JAK inhibitor jak inhibitors JAK/STAT pathway JAK/STAT signaling pathway Janus kinase knowledge locus lung lung tissue Macrophage macrophages neutrophil Patient patients Prevent receptor reduce regulate reported risk factor SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2‐infected SARS‐CoV‐2 severe Covid‐19 severe disease Signaling symptomatic patient T helper target cells the disease therapeutic target TYK2 viral endocytosis virus replication
[DOI] 10.1002/eji.202149173 PMC 바로가기 [Article Type] Mini‐Review|Clinical

Arginase 1 ( Arg1 ) as an Up-Regulated Gene in COVID-19 Patients: A Promising Marker in COVID-19 Immunopathy

Article

Published on 2021-03-042022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] acute respiratory syndrome Analysis antiviral immune responses antiviral immunity ARG1 arginase AUC Blood caused cDNA characteristic complementary coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients demonstrated diagnostic diagnostic value DNA dysregulated expressed expression Gene Expression global pandemic healthy individual healthy individuals immune cells immune responses macrophages marker myeloid cells neutrophil outbreak Pathogenesis qPCR Real-time PCR relative expression RNA extraction ROC SARS-CoV-2 SARS-COV-2 infection significantly increased the disease was measured Whole blood
[DOI] 10.3390/jcm10051051 PMC 바로가기 [Article Type] Article

At the Crossroads: COVID-19 and Immune-Checkpoint Blockade for Cancer

갈림길에서: COVID-19와 암에 대한 면역 관문 차단

Article

Published on 2021-03-012022-09-11
Journal: Cancer immunology research [Category] 바이오마커,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral immune response antiviral immune responses blockade Cancer Characteristics clinical trials Complication complications of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccination death decrease detrimental disease course Effect Evidence expression heterogeneity immune responses immunomodulatory effect immunomodulatory effects infections Inflammatory inflammatory complications Inflammatory response Inflammatory responses interferon interferon signaling leads Ligand MOST pathway Patient patients Patients with cancer PD-L1 PD1 PROTECT provided receiving receptor respiratory respiratory distress Respiratory distress syndrome RNA virus SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases Severe respiratory distress Support syndrome the disease therapy Viral viral infection virus infections worsening
[DOI] 10.1158/2326-6066.CIR-21-0008 PMC 바로가기 [Article Type] Article

The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

GRL0617과 SARS-CoV-2 PLpro의 복잡한 구조는 항바이러스 약물 발견을 위한 핫스팟을 보여줍니다

Article

Published on 2021-01-202022-09-10
Journal: Nature Communications [Category] 변종, 신약개발, 진단, 치료제,

[키워드] Analysis Antiviral antiviral drug antiviral immune responses approved drug approved drugs assays binding binding energy binding pocket block C-terminus complex Compound contribute COVID-19 pandemic crystal structure cysteine cysteine protease domain dominant Drug discovery drug target dysregulation effective examined function Host hot spot identify immune responses implicated in vitro indicate Inflammation inhibit inhibitor inhibitors ISG15 library maturation mechanism mechanism of action mutants Nanocrystallography NMR Papain-like protease pathogen PLPro PPI Protein–protein interaction responsible reveal SARS-CoV-2 screened Structural analysis structural biology viral infection virus
[DOI] 10.1038/s41467-020-20718-8 PMC 바로가기 [Article Type] Article

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages—Potential Implications for Cytokine Storm Syndrome

Communication

Published on 2021-01-152022-10-28
Journal: Vaccines [Category] COVID-19,