SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificityArticle Published on 2022-10-032022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] airway analyzed antiviral immunity Breakthrough infection CD4+ T cell CD8+ COVID-19 COVID-19 vaccinee feature highlight Immunity immunological induce Infection nasal nasal mucosa persistence phenotype Primary infection Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 vaccination SARS-CoV-2-infected cell specificity suppress T cell T cell response vaccination vaccinee [DOI] 10.1084/jem.20220780 PMC 바로가기
Multi-scale mechanism of antiviral drug-alike phytoligands from Ayurveda in managing COVID-19 and associated metabolic comorbidities: insights from network pharmacologyArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] Antiviral antiviral drugs antiviral immunity APCS approach Ayurveda binding affinity cardiovascular complications Comorbidities Comorbidity COVID-19 creating develop Diabetes Mellitus disorders effective highlighting Host hypertension immunomodulators investigated mechanism molecular docking network network pharmacology novel coronavirus disease Protein target public health regulate Regulatory SARS-CoV-2 SARS-CoV-2 proteins synergistic therapy Traditional virus Wuhan, China [DOI] 10.1007/s11030-021-10352-x PMC 바로가기
Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interactionArticle Published on 2022-10-012022-11-15 Journal: Psychoneuroendocrinology [Category] 치료제, [키워드] absence analyzed antibody production antiviral immunity antiviral response association blood sample characterized connection conserved COVID-19 COVID-19 pandemic CTRA disease risk down-regulation Effect eudaimonia examined experience Factors female Gene Expression Health healthy Immune cell immune system Interaction Linear model loneliness measure Multiple offset Online social interaction profile proinflammatory gene quantified question reduced Regulation RNA Social genomics. social interaction transcriptional response [DOI] 10.1016/j.psyneuen.2022.105885 PMC 바로가기
Mechanisms of CD8+ T-cell failure in chronic hepatitis E virus infectionArticle Published on 2022-10-012023-06-12 Journal: Journal of hepatology [Category] E형 간염, [키워드] antiviral immunity CD8+ T-cell response Immunological memory T-cell exhaustion viral escape [DOI] 10.1016/j.jhep.2022.05.019
Characterization of the Immune Resistance of Severe Acute Respiratory Syndrome Coronavirus 2 Mu Variant and the Robust Immunity Induced by Mu InfectionArticle Published on 2022-09-282022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome addition antibody Antiviral antiviral immunity characterization convalescent sera coronavirus coronavirus 2 coronavirus disease COVID-19 determine E484K elicited immune resistance immune resistance. individual induce induced Infection Mu variant Mutation notable resistance respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sera Spike protein the SARS-CoV-2 vaccination Vaccine variant [DOI] 10.1093/infdis/jiac053 PMC 바로가기
How Do Anti-SARS-CoV-2 mRNA Vaccines Protect from Severe Disease?Article Published on 2022-09-082022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 치료제, [키워드] adaptive alveolar alveolar macrophage Alveolar macrophages antiviral immunity approach benefit consequence COVID-19 Cytokine storm develop diffusion disease dissemination Efficacy elicited epithelial cell expected experimental evidence Extracellular Factor feature Host immune response immune function inhibitory effect intramuscularly Macrophage mechanism messenger mRNA mRNA vaccine mRNA vaccines mucosa other tissue outcome Pathogenesis Prophylaxis Protein Quantitative respiratory respiratory symptom respiratory tracts SARS-CoV-2 severe disease spike Spread TGF-β the cytokine storm upper respiratory tracts Vaccine viral replication virus while [DOI] 10.3390/ijms231810374 PMC 바로가기
Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infectionSARS-CoV-2 감염 시 인터페론 유도, 회피 및 역설적 역할Review Published on 2022-08-012022-09-11 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alleviate antiviral immunity causative agent caused cell type cell types coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death deficiency disease disease severity effort evade function IFN IFN response IFNs immune immune evasion interferon interferons interferons (IFNs location mechanism outcome paradoxical pathway Pathways Protective Research responses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly supported Therapeutics Treatment treatment of COVID-19 Type type I Type I and III IFN virus while [DOI] 10.1111/imr.13113 PMC 바로가기 [Article Type] Review
Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity Research Published on 2022-07-252022-10-05 Journal: Nature Immunology [Category] 변종, [키워드] Activation affecting agonist antagonized antiviral immunity Critical deficiency demonstrated deteriorate DNA domain driver expression genetic code identify IFN IFN signaling IFN-I information inhibited Innate innate antiviral immunity Innate immunity interferon IRF3 IRF7 mechanism mice Mortality nucleus occur regulate rescued restored resulting SIRT1 Type I IFN Viral load viral replication [DOI] 10.1038/s41590-022-01269-0 [Article Type] Research
Psychoneuroimmunology in the time of COVID-19: Why neuro-immune interactions matter for mental and physical healthResearch article Published on 2022-07-012022-10-05 Journal: Behaviour research and therapy [Category] COVID19(2023년), SARS, 비임상, 치료제, [키워드] Affect antiviral immunity Brain COVID COVID-19 COVID-19 pandemic Effect effective Evidence Health immune change immune function immune system Immunity implication infection with SARS-CoV-2 Interaction Intervention Mental Perturbation physical positive Psychological Psychological state psychological states Psychoneuroimmunology Research stressors the vaccine triggered [DOI] 10.1016/j.brat.2022.104104 [Article Type] Research article
SARS-CoV-2 Achieves Immune Escape by Destroying Mitochondrial Quality: Comprehensive Analysis of the Cellular Landscapes of Lung and Blood Specimens From Patients With COVID-19SARS-CoV-2, 미토콘드리아 품질을 파괴하여 면역 탈출 달성: COVID-19 환자의 폐 및 혈액 표본의 세포 환경에 대한 종합 분석Article Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] activated activating alveolar alveolar epithelial cell alveolar epithelial cells alveolar macrophage Alveolar macrophages analyzed antiviral immunity B cell B cells blocked Blood calcium cell count Comprehensive coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients crossfire cytokine Cytokine storm dataset Defense Degradation energy metabolism epithelial epithelial cell epithelial cells escape exacerbated excessive inflammation explain expression Gene Expression HIF1a Host IFI27 immune immune cells Immune escape Inflammation inhibited Interaction interferon landscape lung tissue Lungs Macrophage macrophages manifestation MCU metabolic pathway metabolism Mitochondria mitochondrial mitochondrial fission mitochondrial functions mitochondrial quality. pathway patients with COVID-19 Perspective plasma pro-inflammatory Regulatory T cell regulatory T cells released Replication respiratory capacity resulting RNA-sequencing SARS-CoV-2 significant changes in Single-cell RNA-sequencing T cells target transformation Tregs type I viral infection [DOI] 10.3389/fimmu.2022.946731 PMC 바로가기 [Article Type] Article