The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemicReview Published on 2022-12-012023-07-10 Journal: Pharmacological Reports [Category] COVID19(2023년), [키워드] Apoptosis Caspases Cathepsins cell death COVID-19 Lysosomes Proteases pyroptosis SARS-CoV-2. [DOI] 10.1007/s43440-022-00394-9 PMC 바로가기 [Article Type] Review
SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemiaArticle Published on 2022-12-012023-07-10 Journal: Redox Biology [Category] COVID19(2023년), [키워드] Apoptosis Apoptosis inducing factor (AIF) Dynamin related protein 1 (Drp1) HCoV-OC43 hypoxic pulmonary vasoconstriction mitochondrial fission Mitochondrial permeability transition pore (mPTP) Murine hepatitis virus (MHV-1). [DOI] 10.1016/j.redox.2022.102508 PMC 바로가기
COVID-19 causes neuronal degeneration and reduces neurogenesis in human hippocampusArticle Published on 2022-12-012022-11-16 Journal: Apoptosis [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Alter Analysis Apoptosis assist Brain cause cells Central nervous system changes in Characteristics CNS COVID-19 degeneration demonstrated died distribution Effect glial cell glial cells granular hippocampus histological impairment increase in individual mechanisms memory microglia cells MONITOR Morphological morphological change morphology neurodegenerative disorder Neuroinflammation neurological Neuron neuronal neuronal cell organ oxidative stress recent reduce SARS-COV-2 infection Sholl analysis. the disease tissue sample virus while [DOI] 10.1007/s10495-022-01754-9 PMC 바로가기
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
Systematic comparison of ranking aggregation methods for gene lists in experimental resultsArticle Published on 2022-10-312022-11-16 Journal: Bioinformatics [Category] COVID19(2023년), meta-analysis, SARS, [키워드] addition aggregation Algorithm Apoptosis automated Bacteria biological process Cancer Cell Characteristics code Consensus database dataset datasets disease downloaded Evaluating Features genomic data heterogeneity implementation implicated Inclusion information lack list of gene lung cancer Macrophage Meta-analysis noise level question reliability required resulting specific type Support the SARS-CoV-2 virus Variation was performed were used [DOI] 10.1093/bioinformatics/btac621 PMC 바로가기
Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2Article Published on 2022-10-162022-11-15 Journal: Communications Biology [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activate antivirals Apoptosis blocked Ebola virus Extracellular glycoprotein herpes simplex virus inhibit inhibited kinase Kinase inhibitor outer membrane Phosphorylation plasma membrane promote Protein pseudotyped receptor engagement SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike protein signaling pathway subsequent target translocation triggered triggering unique vesicular stomatitis virus viral entry virus VSV [DOI] 10.1038/s42003-022-04067-4 PMC 바로가기
A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin DArticle Published on 2022-10-142022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Apoptosis changes in Chromatin structure contribute COVID-19 COVID-19 infections disease risk drug Effect Epigenetic epigenetic modification epigenetics Evidence Gene Expression Health help highlight Host immune response Immunity immunomodulatory effect indicate individual Infection Inflammation involved mechanisms Modification modulated multifunctional outcomes pathophysiology Prevent proliferation receptor receptor function reduced regulate SARS-CoV-2 target therapeutic therapeutic drug Treatment Vaccine viral outbreak virus Vitamin D vitamin D. while [DOI] 10.3390/ijms232012292 PMC 바로가기
The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosisArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] 진단, [키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors receptors. regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent [DOI] 10.3389/fimmu.2022.882921 PMC 바로가기
Systemic redox imbalance in severe COVID-19 patientsArticle Published on 2022-10-012023-07-10 Journal: Cell biochemistry and function [Category] COVID19(2023년), [키워드] Apoptosis Inflammation oxidative stress Reactive oxygen species. SARS-CoV-2 [DOI] 10.1002/cbf.3735 PMC 바로가기
Genome-wide transcriptional profiling of pulmonary functional sequelae in ARDS- secondary to SARS-CoV-2 infectionArticle Published on 2022-10-012023-07-10 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), [키워드] acute respiratory distress syndrome Apoptosis Diffusion impairment Post-COVID RNA-seq. [DOI] 10.1016/j.biopha.2022.113617 PMC 바로가기