The Efficient and Practical virus Identification System with ENhanced Sensitivity for Solids (EPISENS-S): A rapid and cost-effective SARS-CoV-2 RNA detection method for routine wastewater surveillance고형물에 대한 감도가 향상된 효율적이고 실용적인 바이러스 식별 시스템(EPISENS-S): 일상적인 폐수 감시를 위한 빠르고 비용 효율적인 SARS-CoV-2 RNA 검출 방법Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] applicability centrifugation city collected Concentration confirmed COVID-19 case COVID-19 demonstrated Detection sensitivity efficient Epidemiology evaluated examined followed by heat heat-inactivated identification Japan magnitude Mild multiplex normalized pellet Pepper mild mottle virus plant primer Primers qPCR qPCR quantification qPCR. Quantification method quantified ranged reported reverse primer reverse primers RNA concentration RNA concentrations RNA extraction SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity Solid subsequent Surveillance System target targets the SARS-CoV-2 Treatment virus wastewater Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.157101 PMC 바로가기 [Article Type] Article
Optimizing the implementation of a participant-collected, mail-based SARS-CoV-2 serological survey in university-affiliated populations: lessons learned and practical guidanceArticle Published on 2022-10-122022-11-15 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 진단, [키워드] antibody applicability approach Blood change distribution driven by enrolled Epidemiologic methods feasibility Field epidemiology Future Guidance highlight identify implementation Laboratory Massachusetts Pathogens pre-symptomatic Prevalence recruitment Research SARS-CoV-2 SARS-CoV-2 antibody serological survey serological test serology Serosurveys. Spread stratified Study design Study participants subclinical infection symptomatic individual USA utility virus [DOI] 10.1186/s12889-022-14234-1 PMC 바로가기
Diagnostic efficiency of RT-LAMP integrated CRISPR-Cas technique for COVID-19: A systematic review and meta-analysisArticle Published on 2022-10-012022-11-15 Journal: Pathogens and global health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Accuracy applicability article calculated Care chain conducted confidence interval COVID-19 COVID-19 diagnosis COVID-19 pandemic CRISPR-Ca CRISPR-Cas database Diagnosis diagnostic Diagnostic method Efficiency eligibility criteria epidemiological equipment False-positive faster feasible forest plot isothermal amplification limit management Meta-analysis Meta-analysis. molecular N gene Precision problem QUADAS-2 Quantitative reaction Region regions resource reverse transcription RT-LAMP RT-qPCR SARS-CoV-2 sensitivity specificity systematic review Transcription USA was performed with COVID-19 [DOI] 10.1080/20477724.2022.2035625 PMC 바로가기
Live-attenuated YF17D-vectored COVID-19 vaccine protects from lethal yellow fever virus infection in mouse and hamster modelsArticle Published on 2022-09-012022-11-15 Journal: EBioMedicine [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Alpha variant Anti-vector immunity applicability benefit cellular immunity coronavirus COVID-19 vaccine Dual vaccine Efficacy evaluated Fever hamster hamsters highly pathogenic humoral Immunity induce Infection interfere Liver disease mice platform pre-existing immunity PROTECT resulting SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 vaccines single dose subsequent vaccination Vaccine vaccine candidate Vaccines Viral vector vaccine virus virus infection yellow fever Yellow fever vaccine. [DOI] 10.1016/j.ebiom.2022.104240 PMC 바로가기
Current status of antihistamine drugs repurposing for infectious diseasesReview article Published on 2022-09-012022-10-05 Journal: Medicine in Drug Discovery [Category] 신약개발, [키워드] active against Anti-infective Antihistamines applicability article Blood brain barrier Candida carried Chemical library clinical trial clinical trials cross current determine dose drug Ebola virus Efficacy English eventual need FIVE Google Scholar Government groups growth Health hepatitis C IC50 identify in vitro activity in vitro data in vivo Infectious disease information inhibited intrinsically lack Leishmania objective off-label Pathogens pharmacological Plasmodium repurposing Research Result rodents Side effects Staphylococcus aureus Staphylococcus epidermidis Support suppressed Trial Trypanosoma virus [DOI] 10.1016/j.medidd.2022.100140 [Article Type] Review article
Hundreds-Dollar-Level Multiplex Integrated RT-qPCR Quantitative System for Field DetectionArticle Published on 2022-09-012022-11-15 Journal: Biosensors [Category] SARS, 치료기술, 치료제, [키워드] accelerate addition amplification applicability approach ASF characterized comparable Complete conducted COVID-19 COVID-19 pandemic crown detection diagnosing Diagnosis diagnostic disease equipment field fluorescence detection Good Health Laboratory lack low cost molecular Nucleic acid detection on-site testing Outbreaks outcomes PCR polymerase chain provide Quantitative Real-time PCR real-time PCR. reliability RT-qPCR SARS-CoV-2 pneumonia sensitivity specificity stability System target gene Transport World Health Organization [DOI] 10.3390/bios12090706 PMC 바로가기
[Recent advances in clustered regularly interspaced short palindromic repeats-based detection of severe acute respiratory syndrome coronavirus 2]Article Published on 2022-09-012022-11-15 Journal: Se pu = Chinese journal of chromatography [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome applicability caused Characteristics Chinese clustered regularly interspaced short palindromic repeats (CRISPR) coronavirus coronavirus disease COVID-19 CRISPR Diagnosis diagnostic Diseases English Epidemic equipment global public health introduced isothermal Isothermal nucleic acid amplification Mutation nucleic acid Nucleic acid detection palindromic repeat polymerase chain provide reported RT-qPCR SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Spread [DOI] 10.3724/SP.J.1123.2022.08001 PMC 바로가기
Cell-Based Platform for Antigen Testing and Its Application for SARS-CoV-2 InfectionArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] active infection acute respiratory syndrome amplification Antigen antigen test applicability application asymptomatic individual Calu-3 can be used CAR CAR T-cell Care Cell cell line cell-based sensors characterized Community competent conducted control sample coronavirus COVID-19 COVID-19 diagnostics detect diagnosing effective facilitate function Health host cell implementation individual infected with SARS-CoV-2 Infection infections lack mice molecular mRNA offer oropharyngeal swab pandemic Pandemics PCR platform Preclinical present antigen qPCR quantitative PCR reporter reporter cell. robust SARS-CoV-2 Signaling specificity spike glycoprotein symptomatic target pathogen tested Testing viruses Volume [DOI] 10.1128/spectrum.00731-22 PMC 바로가기
A Randomized, Placebo-Controlled Clinical Trial of Bamlanivimab and Etesevimab Together in High-Risk Ambulatory Patients With COVID-19 and Validation of the Prognostic Value of Persistently High Viral Load코로나19 고위험 보행 환자를 대상으로 한 밤라니비맙과 에테세비맙의 무작위 위약 대조 임상 시험 및 지속적으로 높은 바이러스 부하의 예후 가치 검증Randomized Controlled Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 임상, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age ambulatory ambulatory patient ambulatory patients antibody treatment applicability bamlanivimab baseline characterized clinical clinical status Cohort confidence interval coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 test Day death determine etesevimab expand first positive greater high risk Hospitalization infused Interim analyses interim analysis intravenously investigated load lower dose median median age Mild-to-moderate NCT04427501 occurred optimal dose outcome Patient persistently high viral load. phase Placebo placebo group receiving reduction in respiratory risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 Support the placebo group These data those receiving placebo Treatment Trial validation value variant Viral Viral load [DOI] 10.1093/cid/ciab912 PMC 바로가기 [Article Type] Randomized Controlled Trial
Early-stage COVID-19 pandemic observations on pulmonary embolism using nationwide multi-institutional data harvesting Research Published on 2022-08-192022-10-05 Journal: NPJ Digital Medicine [Category] 임상, 치료기술, 치료법, [키워드] 2020 COVID-19 pandemic Accuracy Analysis applicability approach Computed tomography contribute COVID-19 outbreak COVID-19 pandemic CTPA Effect evaluate expected exploratory Final healthcare Healthcare system natural language processing observation performed positive retrospective significantly higher statistically the United State [DOI] 10.1038/s41746-022-00653-2 [Article Type] Research