Dumbbell-type triplex molecular switch-based logic molecular assays of SARS-CoV-2Article Published on 2022-11-152022-10-06 Journal: Sens Actuators B Chem [Category] 진단, [키워드] acute respiratory syndrome amplification approach caused coronavirus COVID-19 COVID-19 pandemic cross-contamination Detection limit diagnostics Dumbbell-type triplex molecular switch Epidemics Frame gold standard High-fidelity independent Logic-gate molecular Molecular assay N gene nucleic acid amplification ORF1ab probe recognizing Region RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 RNA detection SARS-CoV-2 RNA. spacer [DOI] 10.1016/j.snb.2022.132579 PMC 바로가기 [Article Type] Article
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA virusesArticle Published on 2022-11-072022-11-16 Journal: EMBO Reports [Category] SARS, 변종, [키워드] Antiviral approach cell line Complexes CRISPR DDX42 DDX42 DEAD-box RNA helicase Depletion DNA dominant-negative elements expression Helicase HIV-1 HIV-1 infection identify immunoprecipitation in vitro increase Infection inhibit inhibitor Interaction intrinsic intrinsic immunity LINE-1 mutant overexpression Perspective primary cells Replication restrict reverse transcription ribonucleoprotein RNA RNA virus RNA viruses RNA-seq analysis SARS-CoV-2 target cells viral infections viral inhibition. viruses [DOI] 10.15252/embr.202154061 PMC 바로가기
A comparison of conventional and advanced electroanalytical methods to detect SARS-CoV-2 virus: A concise reviewArticle Published on 2022-11-012022-11-15 Journal: Chemosphere [Category] COVID19(2023년), SARS, 치료기술, [키워드] approach approaches Computed tomography COVID-19 COVID-19 disease COVID-19 virus Critical detect detection develop disease electrochemical biosensor equipment identify improvement isothermal amplification Modified electrode outbreak pandemic disease PCR Point point of care polymerase chain polymerase chain reaction Research researcher researchers respiratory SARS-CoV-2 SARS-CoV-2. serology test virus virus virus detection [DOI] 10.1016/j.chemosphere.2022.135645 PMC 바로가기
COVID-19 in patients with B cell immune deficiencyArticle Published on 2022-11-012022-11-16 Journal: Journal of Immunological Methods [Category] SARS, 변종, [키워드] approach B cell B cell immunodeficiency clinical feature clinical manifestation COVID-19 COVID-19 in patient deficiency develop disease immune Isolation management Patient PIDD Precaution Prophylaxis Prospective clinical trial risk factor SARS-CoV-2 unique vaccination vaccine. with COVID-19 [DOI] 10.1016/j.jim.2022.113351 PMC 바로가기
Discovering COVID-19 state sustainable policies for mitigating and ending the pandemicShort communication Published on 2022-11-012022-10-05 Journal: Cities [Category] 변종, [키워드] approach approach calculated country COVID-19 COVID-19 pandemic death decrease effective evaluate IMPROVE increase mitigate outcome pandemic pharmacological Research Scoring Scoring policies suppress Test-isolation policy The number of deaths vaccination [DOI] 10.1016/j.cities.2022.103865 [Article Type] Short communication
Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approachesArticle Published on 2022-11-012022-11-15 Journal: Chemico-biological interactions [Category] SARS, 치료제, [키워드] 3D structure ACE2 addition antiparasitic approach binding binding energy caused cleavage site COVID-19 Diminazene aceturate disease drug enzyme evaluate experimental model in silico in vitro in vivo inhibit Interaction M pro membrane molecular molecular docking molecular target Prevent processed promote protease Protein Protein Data Bank PyMol reduction in S1 and S2 SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2. spike receptor-binding domain stability targets tested viral replication virus infection was used [DOI] 10.1016/j.cbi.2022.110161 PMC 바로가기
Covid-MANet: Multi-task attention network for explainable diagnosis and severity assessment of COVID-19 from CXR imagesResearch article Published on 2022-11-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 진단, 치료기술, [키워드] Accuracy approach approach assigned automated Bacterial chest X-ray CNN conducted COVID-19 COVID-19 case COVID-19 cases COVID-19 diagnosis COVID-19 disease COVID-19 infection Critical CXR dataset deep learning develop Diagnosis disease early diagnosis eight experiment Explainable AI False negative Final first stage Health highlight IMPROVE Infection Infection Segmentation initial Interpretation lung Lung segmentation Lungs measure Mild moderate outbreak outperform Pneumonia predicted proportion quantification radiological examination reduced Region reported Research research finding RT-PCR test scoring system sensitivity sensitivity analysis severity severity of COVID-19 Stage Support transfer learning Tuberculosis Viral pneumonia with COVID-19 [DOI] 10.1016/j.patcog.2022.108826 [Article Type] Research article
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targetsArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 3CL pro 3CLpro acting antiviral activity approach approach binding binding free energy complex COVID-19 dimeric docked complexes docking explained FDA-approved drug FIVE heterodimeric Host in vitro activity inhibit inhibitor inhibitory activity Ivermectin MD simulation molecular molecular docking Molecular dynamics simulation molecular dynamics simulation. molecular mechanism nuclear previous study protease Proteins reached Replication responsible SARS-CoV-2 SARS-CoV-2 replication shown Structural analysis structural property target translocation variety virus with COVID-19 [DOI] 10.1080/07391102.2021.1911857 PMC 바로가기
Global Regulatory and Public Health Initiatives to Advance Pediatric Drug Development for Rare DiseasesArticle Published on 2022-11-012022-11-16 Journal: Therapeutic innovation & regulatory science [Category] 신약개발, [키워드] advance affected approach children clinical trials COVID-19 COVID-19 pandemic development disease drug ecosystem Efficacy effort engage equity facilitate Follow-up include initiative key factor lack outcome measure Patient pediatric pediatric drug development promote Public public health rare disease rare diseases Regulatory Regulatory policy. Study design Therapies Trial trials [DOI] 10.1007/s43441-022-00409-w PMC 바로가기
Utilization of the Abbott SARS-CoV-2 IgG II Quant Assay To Identify High-Titer Anti-SARS-CoV-2 Neutralizing Plasma against Wild-Type and Variant SARS-CoV-2 VirusesArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] 95% confidence interval Abbott Abbott SARS-CoV-2 IgG acute respiratory syndrome Analysis approach approach authorization BAU Beta binding antibody unit Canada CCP characterized Chicago Chicago IL clinical trial convalescent convalescent plasma coronavirus COVID-19 COVID-19 convalescent plasma Cutoff Delta disease course drug Emergency EUA evaluated Evidence experiment FDA food Gamma highest hospitalized patient Humoral immunity identify IgG immune IMPROVE Mann-Whitney U method comparisons Neutralization assay Neutralizing neutralizing antibody outcome Patient patient group plaque reduction neutralization plaque reduction neutralization. plasma PRNT quantitative determination required SARS-CoV-2 SARS-CoV-2 antibody selected significantly specimen tested the SARS-CoV-2 time-consuming treat United State utilization variant VLP VoC wild-type with COVID-19 [DOI] 10.1128/spectrum.02811-22 PMC 바로가기