Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units확장된 COVID-19 중환자실에서 2차 감염 치료 및 병원 전파 감지를 개선하기 위한 호흡기 메타유전체학의 잠재력 평가Research Published on 2021-11-172022-09-10 Journal: Genome Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI absence added Antibiotic resistance Antibiotics approach Aspergillus fumigatus Bacterial carried clinical clinical assessment COVID-19 COVID-19 pandemic Critical care Culture detect evaluated Evaluating expansion Genome genomic Genomic surveillance ICU ICUs IMPROVE increased risk Infection infection control infections initial intensive care unit intubated patient Laboratory MDR modify Nanopore nanopore sequencing nosocomial Nosocomial transmission outbreak pathogen pathogen detection Pathogens Patient pneumoniae positive presence or absence provide quantitative PCR reported Research respiratory respiratory sample Respiratory samples Result SARS-CoV-2 pandemic Secondary infection Sequencing sequencing data Seven supplementary material Surveillance translated Transmission Treatment [DOI] 10.1186/s13073-021-00991-y PMC 바로가기 [Article Type] Research
Mixed Etiology COVID-19 Associated Pulmonary Aspergillosis (CAPA)—A Case Report and Brief Review of the LiteratureCase Report Published on 2021-10-182022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] Aspergillus section Flavi Aspergillus section Fumigati addition aspergillosis Aspergillus Aspergillus fumigatus CAPA Co-infection COVID-19 COVID19 etiology high mortality rate Infection information Interaction invasive IPA literature Mortality Patient presenting pulmonary report Research review risk Romania SARS-CoV-2 SARS-CoV-2 pandemic therapy [DOI] 10.3390/jof7100877 PMC 바로가기 [Article Type] Case Report
Fungal Genomics in Respiratory Medicine: What, How and When?호흡기 의학의 진균 유전체학: 무엇을, 어떻게, 언제?Review Published on 2021-09-072022-09-10 Journal: Mycopathologia [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Aspergillus fumigatus acute respiratory distress acute respiratory distress syndrome advance aspergillosis Aspergillus fumigatus azole cause of death caused coronavirus coronavirus disease Coronavirus disease-19 COVID-19 Critical death Diagnosis Diagnostic method diagnostics early diagnosis form fungal Fungal infection fungal infections fungal pathogen fungal pathogens Genomics Health higher risk Immunocompromised patients include Infection infections molecular molecular diagnostics Mortality Mucormycosis Mycoses pathogen Pathogens Patient patient survival pulmonary aspergillosis respiratory respiratory diseases respiratory distress Respiratory distress syndrome respiratory infections resulting shown syndrome treated triazole [DOI] 10.1007/s11046-021-00573-x PMC 바로가기 [Article Type] Review
A review of significance of Aspergillus detection in airways of ICU COVID-19 patientsICU COVID-19 환자의 기도에서 Aspergillus 검출의 중요성 검토Review Published on 2021-09-012022-09-11 Journal: Mycoses [Category] SARS, 치료기술, [키워드] airway Antifungal treatment Antigen Aspergillus Aspergillus fumigatus Atypical colonisation COVID-19 COVID-19 patient COVID-19 patients criteria Culture decision galactomannan highlight ICU Infection intensive care intensive care unit invasive Invasive pulmonary aspergillosis IPA mechanically ventilated mechanically ventilated patients Mortality mortality. Patient patients with SARS-CoV-2 PCR performed pulmonary aspergillosis radiological receiving risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia specimen Symptomatology treat Treatment [DOI] 10.1111/myc.13341 PMC 바로가기 [Article Type] Review
Antifungal Drug Susceptibility and Genetic Characterization of Fungi Recovered from COVID-19 PatientsArticle Published on 2021-07-112022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] Aspergillus fumigatus Candida albicans Candida parapsilosis Candida pneumonia 30-Day mortality A. fumigatus Analysis analyzed Antifungal antifungal susceptibility aspergillosis Aspergillus fumigatus azole drug Blood bloodstream infection C. albican Candida Candida albican candidiasis center Characteristics characterization chromosomal rearrangement Clinical data Clinical outcome Complication comprehensive analysis Corticosteroids COVID-19 COVID-19 patient COVID-19 patients COVID-19-associated candidemia determinant drug elevated fungal fungi genotypes Hospital stay Hospitalized Immunosuppression Infection initial intensive care intrinsic isolate isolates limit mechanical ventilation median molecular Mortality New pandemic patient cohort patient population performed Pulsed-field gel electrophoresis recovered respiratory tract respiratory viral infection retrospective secondary infections sequence susceptibility susceptible the patient university USA virus [DOI] 10.3390/jof7070552 PMC 바로가기 [Article Type] Article
Mucormycosis and COVID-19 an epidemic in a pandemic?Short Communication Published on 2021-06-302022-10-30 Journal: Nepal Journal of Epidemiology [Category] COVID-19, [키워드] aspergillosis Aspergillus fumigatus AY.1 B.1.617.2 Case fatality rate caused Complication coronavirus corticosteroid therapy country COVID-19 COVID-19 infection creating death Delta effective Epidemic Genetic global pandemic Health status Immunosuppression India indolent Infection invasive life-threatening management Mycoses Nepal Ophthalmologist pandemic produced reported Rhizopus SARS-CoV-2 SARS-CoV-2 Delta variant SARS-CoV-2 variants Secondary infection syndrome testing protocol the SARS-CoV-2 unique Zygomycosis [DOI] 10.3126/nje.v11i2.37342 PMC 바로가기 [Article Type] Short Communication
Serum amyloid P component is an essential element of resistance against Aspergillus fumigatusArticle Published on 2021-06-182022-10-04 Journal: Nature Communications [Category] 진단, [키워드] A. fumigatus activate Activation administration amyloid Aspergillus fumigatus Bacterial infection cascade classical pathway complement conidia death dependent on ENhance Evidence fungal Fungal infection Genetic variation Host humoral Immunosuppressed in vivo Infection Innate immune cells Innate immunity invasive involved Lungs mice neutrophil Neutrophils pathogen Pathogens phagocytosis PROTECT recruitment Regulation serum amyloid susceptibility tissue remodeling [DOI] 10.1038/s41467-021-24021-y PMC 바로가기 [Article Type] Article
Genomic and Phenotypic Analysis of COVID-19-Associated Pulmonary Aspergillosis Isolates of Aspergillus fumigatusAspergillus fumigatus의 COVID-19 관련 폐 아스페르길루스증 분리물의 게놈 및 표현형 분석Research Article Published on 2021-06-092022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Aspergillus A. fumigatus acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed aspergillosis Aspergillus Aspergillus fumigatus caused Cell cell wall Characteristics characterized Coinfection conducted copy number copy number variant Copy number variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient deleted described drugs etiological agent example expand Factors fungal disease fungal pathogen fungal pathogens genetic determinant Genome Genome sequencing genomes genomic genus Germany global pandemic growth had more information isolate isolates loss-of-function mutation metabolite microbial modulate mutational spectrum North nucleotide osmotic outcome oxidative pathogenicity Pathogens patients treated Phenotypes phenotypic Polymorphisms profile pulmonary pulmonary aspergillosis reference strain reference strains reported respiratory responsible SARS-CoV-2 Secondary infection secondary infections Secondary Metabolite severe acute respiratory syndrome Coronavirus significant difference significant differences significantly more single nucleotide polymorphisms strain Strains stressors subset superinfection virulence virulence factors virulent Wuhan Wuhan, China [DOI] 10.1128/Spectrum.00010-21 PMC 바로가기 [Article Type] Research Article
COVID-19–Associated Pulmonary Aspergillosis, March–August 2020Research Published on 2021-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, MERS, [키워드] Aspergillus acute respiratory distress acute respiratory syndrome administration anticipated aspergillosis Aspergillus fumigatus caused China collected data coronavirus coronavirus disease Coronaviruses COVID-19 cultures cumulative deaths diagnosed Diagnosis drug fungal fungi ICU immune system incidence intensive care intensive care unit lymphocyte mechanical ventilation median MOST Patient pulmonary ranged respiratory infections SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 subsequent syndrome virus viruses voriconazole zoonoses [DOI] 10.3201/eid2704.204895 PMC 바로가기 [Article Type] Research
Antibody-guided in vivo imaging of Aspergillus fumigatus lung infections during antifungal azole treatmentArticle Published on 2021-03-172022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] A. fumigatus approach approach Aspergillus Aspergillus fumigatus can be used caused Complete Critical Diagnosis diagnostic procedure drug early diagnosis Efficacy Ex vivo fluorescence microscopy fungal Fungal infection humans Immunocompromised in vivo Infection Intervention Invasion Invasive pulmonary aspergillosis IPA life-threatening lung Lung disease Lung infection Medical imaging molecular MONITOR monoclonal antibody Non-invasive pathogen patient survival Prevent reveal the disease therapeutic options therapy Treatment [DOI] 10.1038/s41467-021-21965-z PMC 바로가기 [Article Type] Article