A call for discovery: Re‐envisioning The Cancer Genome Atlas as a blueprint for a TCGA2.0—The COVID‐19 Genome AtlasEditorial Published on 2021-10-182022-11-01 Journal: Clinical and Translational Discovery [Category] COVID-19, [키워드] approach Atla atlas benefit Cancer Clinicians complications consequence COVID‐19 creating determinant disease effective Health impacted outcome pandemic Patient provide researchers Scientific community treat [DOI] 10.1002/ctd2.7 PMC 바로가기 [Article Type] Editorial
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation17개의 SARS-CoV-2 단백질의 근위 프로테옴은 항바이러스 신호 전달 및 숙주 번역을 방해합니다.Research Article Published on 2021-10-012022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation antiviral signaling association atlas Card cleavage complex coronavirus Coronaviruses COVID-19 severity CWC22 database Factor FANCD2 Fluorescence functional Host host protein host proteins human cell human protein identify IFNB1 Impact inhibited inhibitor innate immune interferon signaling M protein MAVS membranes nsp1 nsp5 ORF6 Pathogenesis pathogenic coronavirus pathogenic mechanism pathogenic mechanisms pathogenicity peptide peptide sequences promote promoter protease Protein protein translation Proteins proteome proteomics proximal public health threat regulator Regulatory resource RIG-I SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral sequence Signaling subcellular target the SARS-CoV-2 translation translation initiation Transport TRIM4 variant Viral Viral protein Viral proteins [DOI] 10.1371/journal.ppat.1009412 PMC 바로가기 [Article Type] Research Article
An autoantigen profile of human A549 lung cells reveals viral and host etiologic molecular attributes of autoimmunity in COVID-19인간 A549 폐 세포의 자가항원 프로필은 COVID-19에서 자가면역의 바이러스 및 숙주 병인 분자 특성을 나타냅니다Article Published on 2021-06-012022-09-12 Journal: Journal of autoimmunity [Category] MERS, SARS, 진단, [키워드] A549 A549 cells activating Affect alteration alterations Apoptosis atlas attribute autoantibodies autoantigen Autoantigens Autoimmune Autoimmune disease Autoimmunity biogenesis caused CDK11A cellular changes in COVID COVID-19 degranulation Gene Expression Host human lung IL-12 immune responses induce lung lung cell membrane mitochondrial ribosomal proteins mitochondrial ribosome modify molecular mRNA metabolism NSP Platelet PLD3 PRKDC Protein provide PSAT1 RAB1A resource Resource. reveal ribonucleoprotein SARS-COV-2 infection Signaling significantly SLC2A1 target transcript translation Transport UBA1 UCHL1 unique USP7 Vesicle viral infection Viral protein viral replication [DOI] 10.1016/j.jaut.2021.102644 PMC 바로가기 [Article Type] Article
Prognostic Significance of COVID-19 Receptor ACE2 and Recommendation for Antihypertensive Drug in Renal Cell CarcinomaResearch Article Published on 2020-11-252022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] ACE ACE2 ACE2 expression acute respiratory syndrome anti-hypertensive drug antihypertensive antihypertensive agent atlas Cell cell membrane coronavirus coronavirus disease COVID-19 Cox proportional hazard Cox regression downloaded drug enzyme Epidemic genomic data glioblastoma multiforme increase inhibitor Kaplan-Meier Kaplan-Meier curve kidney log-rank test Lungs material Melanoma molecular docking offer pandemic patients Prognosis prognostic Prostate renal renal cell carcinoma Research Result Significance Spread statistical significance surface protein survival rate Thyroid uveal World Health Organization [DOI] 10.1155/2020/2054376 PMC 바로가기 [Article Type] Research Article
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor Research Published on 2020-10-192022-10-05 Journal: Nature Genetics [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome amino acids angiotensin-converting enzyme 2 atlas binding cause cellular entry Co-infection condition coronavirus COVID-19 expression full-length SARS-CoV-2 independent induce Infection Inflammatory interferon-stimulated gene ISG isoform lack outcomes promote receptor SARS-CoV-2 Spike protein susceptibility target cells the SARS-CoV-2 transcriptionally Tumor tumor microenvironment unlikely Variability virus [DOI] 10.1038/s41588-020-00731-9 [Article Type] Research
Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptomSARS-CoV-2 감염 매개체와 말초 후각 수용체의 동시 발현: COVID-19 증상으로서 후각 상실 이상의 잠재적 의미Article Published on 2020-09-012022-09-11 Journal: International journal of molecular medicine [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome adipose Adipose tissue analysed angiotensin Anosmia atlas bladder Brain cathepsin L caused Cell cellular protease Clinical studies clinical study COVID‐19 CTSL damage disease enzyme expressed expression expression profile facilitated function GeneMANIA healthy heart highlight host cells host cells) human host cell human host cells Hyposmia implication in vitro Infection interact kidney liver Local Loss of Smell mechanism mediators nasal New olfactory olfactory bulb olfactory receptor OR51E2 pancrea pancreas periphery plethora Potential Profiling Prostate protease receptor required respiratory Serine serine 2 Severe acute respiratory syndrome significantly Symptom Testis Thyroid tissue tissues TMPRSS2 transmembrane transmembrane protease serine 2 upregulated [DOI] 10.3892/ijmm.2020.4646 PMC 바로가기 [Article Type] Article
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cellsResearch Paper Published on 2020-06-182022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 mRNA ACE2 protein analyzed angiotensin-converting enzyme 2 atlas average Blood blood cell Blood cells caused Cell collected Concentration dataset determine distribution enzyme expressed expression females functional Gallbladder Health heterogeneity HPA human tissue human tissues humans Immunochemistry involved kidney lack male mechanism membrane mRNA mRNA expression mRNA level organ outbreak Placenta plasma Pneumonia previous study profile Protein protein level proteomic putative receptor receptor Research risk RNA-Seq SARS-CoV-2 SARS-COV-2 infection secreted protein Secretome small intestine suggested susceptibility tissue tissues transmission route was determined [DOI] 10.7150/ijms.46695 PMC 바로가기 [Article Type] Research Paper
In Silico Discovery of Candidate Drugs against Covid-19Article Published on 2020-04-062022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 angiotensin converting enzyme Aryldialkylphosphatase atlas bioinformatics biosynthetic candidate Cell cell receptor co-expressed correlated COVID-19 dataset Didanosine drug drugs effective drug evaluated Evidence Final Flutamide fluticasone function Gene Expression Omnibus gene expression profile gene network Gene ontology Genes in silico Infection Interaction investigated lung mechanism nimesulide Pathway enrichment analysis Potential treatment previous study protein-protein interaction provided reported SARS-CoV SARS-CoV-2 Thiabendazole Treatment virus [DOI] 10.3390/v12040404 PMC 바로가기 [Article Type] Article
Smoking Upregulates Angiotensin-Converting Enzyme-2 Receptor: A Potential Adhesion Site for Novel Coronavirus SARS-CoV-2 (Covid-19)Editorial Published on 2020-03-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome adhesion Analysis angiotensin-converting enzyme-2 atlas China collected COPD COVID-19 death rate Electronic cigarettes expected fatality female Heat-Not-Burn Indonesia IQOS Iran Italy likelihood male males microbial infections much lower novel Older outbreak Potential potential therapeutic target receptor reported Research Respiratory Coronavirus respiratory viruses SARS-CoV SARS-CoV-2 Site smoker smoking smoking status South Korea Tobacco vaping virus [DOI] 10.3390/jcm9030841 PMC 바로가기 [Article Type] Editorial
Rapid Detection and Classification of Salmonella enterica Shedding in Feedlot Cattle Utilizing the Roka Bioscience Atlas Salmonella Detection Assay for the Analysis of Rectoanal Mucosal Swabsarticle Published on 2017-10-312024-09-01 Journal: J Food Prot [Category] 살모넬라증, [키워드] atlas beef cattle Immunomagnetic separation Rectoanal mucosal swab Salmonella shedding [Article Type] article