Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes게놈 전반에 걸친 분석을 통해 SARS-CoV-2 바이러스 유전자 Orf9c가 인간 다능성 줄기 세포 유래 심근세포에 미치는 해로운 영향을 보여줍니다Article Published on 2022-03-082022-09-11 Journal: Stem Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] Abnormalities abnormality acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated analyses analysis Apoptosis apoptotic approved ATP ATP synthesis cardiac dysfunction cardiac injury cardiomyocyte caused Cell cellular characterized coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death defined detrimental detrimental effect detrimental effects disease down-regulated drug Drug administration dysfunction electrical ENCODE expression Factor Factors food functional Genes Genome heart disease heart muscle human pluripotent stem cell Impact Inflammation Injury Ivermectin manifestation Manifestations meclizine meclizine. molecular mechanism molecular mechanisms Orf9c overexpression Pathways Protein Proteins Proteomic analysis reduced respiratory restored SARS-CoV-2 SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathways significantly stem cell therapeutic approach Transcriptomic analyses Transcriptomic analysis U.S. Food and Drug Administration up-regulated [DOI] 10.1016/j.stemcr.2022.01.014 PMC 바로가기 [Article Type] Article
Case Report: Hypergranular Platelets in Vaccine-Induced Thrombotic Thrombocytopenia After ChAdOx1 nCov-19 VaccinationCardiovascular Medicine Published on 2022-02-092022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Admission antibody anticoagulation treatment approach ATP ChAdOx1 ChAdOx1 nCov-19 vaccination characterized contribute D-dimer female Granule healthy healthy control help hematological parameter highlight hospital investigated marker morphology observation parameter pathology Patient Peripheral blood peripheral blood smear Platelet Platelets Population presentation reduced remained returned SARS-CoV-2 vaccination study period TEM the patient therapeutic decision thrombocytopenia thrombosis thrombotic thrombotic risk transmission electron microscopy Treatment vaccination vaccine-induced thrombotic thrombocytopenia (VITT) venous was increased were assessed [DOI] 10.3389/fcvm.2022.824601 PMC 바로가기 [Article Type] Cardiovascular Medicine
Effects of laser acupuncture tele-therapy for rheumatoid arthritis elderly patientsRandomized Controlled Trial Published on 2022-02-012022-10-05 Journal: Lasers in medical science [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 addition aerobic antioxidant approach Arthritis assigned ATP autoimmune disorder C-reactive protein (CRP COVID-19 pandemic CRP disease disorder Effect effective elderly Elderly patient functional Geriatrics group Health Assessment IL-6 Inflammatory marker interleukin-6 Laser Laser acupuncture marker MDA methotrexate oxidative Patient physical Prognosis questionnaire Randomly reduction Rheumatoid rheumatoid arthritis significant increase significantly statistically significant statistically significant difference tele-rehabilitation. the patient treated Treatment [DOI] 10.1007/s10103-021-03287-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
Designing of peptide aptamer targeting the receptor-binding domain of spike protein of SARS-CoV-2: an in silico studySARS-CoV-2의 스파이크 단백질 수용체 결합 도메인을 표적으로 하는 펩타이드 앱타머 설계: in silico 연구Article Published on 2022-02-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] ACE2 albumin antibodies approach aptamer ATP Bacterial bind CD4 complex coronavirus docked domain ENCODE envelope Genome high affinity host cell in silico membrane metal ions molecular molecular docking molecular dynamic simulation monoclonal antibodies non-allergenic non-hemolytic nucleocapsid peptide Peptide aptamer predicted Protein Proteins Receptor-binding domain SARS-CoV-2 scaffold protein serum albumin specificity spike Spike protein spike protein. spike receptor-binding domain stability target target protein tertiary structure the receptor-binding domain theophylline Therapeutic treatment thioredoxin thrombin virus [DOI] 10.1007/s11030-020-10171-6 PMC 바로가기 [Article Type] Article
CTD of SARS-CoV-2 N protein is a cryptic domain for binding ATP and nucleic acid that interplay in modulating phase separationSARS-CoV-2 N 단백질의 CTD는 상분리를 조절하는 데 상호작용하는 ATP 및 핵산 결합을 위한 비밀 도메인입니다Article Published on 2022-02-012022-09-11 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), SARS, 변종, 치료법, [키워드] affinity anti-SARS-CoV-2 ATP ATP: Nucleic acid bind binding binding domain cellular Complete Concentration Critical CTD domain drug target function generate gRNA host cell interface intrinsically life cycle liquid-liquid phase separation (LLPS) living cell modulating MOST N protein NMR NMR spectroscopy NTD nucleic acid nucleocapsid nucleocapsid (N) protein. offer pandemic probe Protein regions representing residue Result SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid SARS-CoV-2 variants structures target targets the SARS-CoV-2 unique variant viral life cycle virus [DOI] 10.1002/pro.4221 PMC 바로가기 [Article Type] Article
Role of CD39 in COVID-19 Severity: Dysregulation of Purinergic Signaling and ThromboinflammationCOVID-19 중증도에서 CD39의 역할: 퓨린성 신호 전달 및 혈소판 염증의 조절 장애Immunology Published on 2022-01-312022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] 95%CI adenosine adjusted odds ratio Admission ADP association ATP Biomarker blocked caused CD39 clinical parameter Cohort contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity disorder dysregulation expression Extracellular healthy control homeostasis Hospital stay Hypoxemia hypoxia ICU admission Immune cell indicate Inflammatory Influenza influenza A inhibitor intensive care intensive care unit admission maintain nucleotide nucleotides overexpressed overexpression pathophysiology pathway Patient patients hospitalized plasma platelet activation Pneumonia prospective cohort Purinergic purinergic dysregulation receptor resulting role selected Severe COVID-19 pneumonia severity Signaling subset suggested systemic inflammation Thromboinflammation ticagrelor was related [DOI] 10.3389/fimmu.2022.847894 PMC 바로가기 [Article Type] Immunology
Multiple conformations of trimeric spikes visualized on a non-enveloped virusArticle Published on 2022-01-272022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, 치료제, [키워드] ATP C-terminal C-terminal domain cascade cellular membrane conformation conformations Cryoelectron microscopy cytoplasmic cytosolic domain host cells insertion Integrins membrane monomer Multiple N-terminal N-terminal domain Reoviridae RNA S-adenosylmethionine SAM spikes Structure Transcription Trigger triggered trimeric trimeric spike viral infection virus virus Virus structures [DOI] 10.1038/s41467-022-28114-0 PMC 바로가기 [Article Type] Article
Effectiveness of various cleaning strategies in acute and long-term care facilities during novel corona virus 2019 disease pandemic-related staff shortages새로운 코로나 바이러스 2019 질병 전염병 관련 직원 부족 동안 급성 및 장기 치료 시설에서 다양한 청소 전략의 효과Research Article Published on 2022-01-212022-09-10 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] ACh adenosine adenosine triphosphate allocation assays ATP Care cleaning Cleanliness conditions Contamination contamination rate COVID-19 pandemic Daily Dementia disease Effectiveness electrostatic enhanced enhancement evaluate fogging followed by help hospital in viral infections involved Long-term care not significantly different novel corona virus outbreak Patient performed positive Prevent proportion Randomly reduction rehabilitation removal resource Result RNA room SARS-CoV-2 RNA SARS-CoV-2 RT-PCR shown stationary Swab Transport media ultraviolet light Viral viral transport media wiping [DOI] 10.1371/journal.pone.0261365 PMC 바로가기 [Article Type] Research Article
The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.Research Article Published on 2022-01-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used [DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article
Channels and Transporters of the Pulmonary Lamellar Body in Health and DiseaseReview Published on 2021-12-242022-10-31 Journal: Cells [Category] COVID-19, SARS, [키워드] acidic pH Alveolar Type II alveolus ambroxol ATII ATP Cell channel clearance complex deficiency disease distress Exocytosis expressed form function innate immune system Ivermectin lack Lamellar Body Ligand Lipid lung lysosome related organelle (LRO) maintain membrane organelle organism Pathogens pathway Proteins pulmonary purinergic signaling receptors reduction responsible SARS-CoV-2 secretion surfactant syndrome tension therapeutic targets transporter viral infection [DOI] 10.3390/cells11010045 PMC 바로가기 [Article Type] Review