Author – Page 2 – Communicable Diseases Research

In vitro selection of Remdesivir resistance suggests evolutionary predictability of SARS-CoV-2

remdesivir 저항의 시험 관내 선택 SARS-COV-2의 진화 적 예측 가능성을 시사한다.

Research Article

Published on 2021-09-172022-08-13
Journal: PLoS Pathogens
[Category] SARS, 변종, 유전자 메커니즘, 치료제,

Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19

광범위하게 지시된 SARS-CoV-2-특이적 CD4+ T 세포 반응에는 급성 및 소실된 COVID-19 환자의 막 및 핵단백질 내에서 자주 검출되는 펩티드 특이성이 포함됩니다.

Research Article

Published on 2021-09-162022-09-10
Journal: PLoS Pathogens
[Category] SARS, 치료기술, 치료법, 치료제,

[키워드] assays Author average binding affinity breadth CD4+ T cell Cohort cohort of patient COVID-19 cytokine data set defined dominant elicited ELISPOT ENCODE enzyme epitope Epitopes Ex vivo examined FIVE Frequency HLA HLA binding HLA class II ICS IFN-γ immune response immune responses immunological Immunopathogenesis in vitro include individual individual immune response interferon interferon-γ intracellular cytokine staining M protein membrane MHC class N protein novel nucleoprotein one patient overlapping Patient patients peptide peptides phenotype Protein resolved response response frequency SARS-CoV-2 envelope SARS-CoV-2 genome SARS-COV-2 infection screened Specificities specificity Spike protein structural protein structural proteins subsequent T cell T cell epitope T cell response T cell responses T cells tetramer the N protein the SARS-CoV-2 the spike protein to define Vaccine design Viral Viral proteins vitro cultivation
[DOI] 10.1371/journal.ppat.1009842 PMC 바로가기 [Article Type] Research Article

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

인간 세포에서 SARS-CoV-2 복제를 늦추는 용도 변경 약물의 발견

Research Article

Published on 2021-09-092022-09-10
Journal: PLoS Pathogens
[Category] SARS, 바이오마커, 신약개발,

[키워드] addition amodiaquine atovaquone Author bedaquiline candidate cell types COVID COVID-19 COVID-19 vaccine COVID-19 vaccines drug Drug repurposing ebastine effective evaluated FDA-approved drugs help hepatocyte hepatocytes human cell human cells Immunity infected cells Infection kidney Liver damage luciferase LY2835219 manidipine measure nLuc panobinostat patients with COVID-19 performed Protein Proteinuria proximal tubule proximal tubule cell proximal tubule cells reduced replication Replication reported Repurposed drug Repurposed drugs required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Screen Spike protein Support the disease the Spike Therapeutics treat treated Treatment utility Vero Cell Vero cells Viral Viral load virus virus replication Vitamin D3
[DOI] 10.1371/journal.ppat.1009840 PMC 바로가기 [Article Type] Research Article

Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

SARS-COV-2 수용체 결합 도메인 항체 인식의 구조적 및 에너지 프로파일 링 및 순환 변이체의 영향

Research Article

Published on 2021-09-072022-09-10
Journal: PLoS Computational Biology
[Category] SARS, 변종, 진단,

[키워드] affected Alpha Analysis antibody atomic Author B.1.1.7 B.1.617.2 binding binding domain circulating variant Clustering Community complex computational modeling Contact COVID-19 pandemic dataset Delta described determinant disrupt epitope epitope conservation evade feature group high resolution highlight identify immune response immune responses less molecular monoclonal antibodies monoclonal antibody Mutation mutations natural infection Neutralizing antibodies performed predicted Protective antibody protective antibody responses RBD Receptor binding domain Research residue residues SARS-CoV-2 pandemic SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus spike glycoprotein Spread Structural analysis Structure structures target the SARS-CoV-2 the SARS-CoV-2 virus therapeutic Unsupervised clustering Vaccine Vaccine design Vaccines variants Viral viral variant Viral variants was used
[DOI] 10.1371/journal.pcbi.1009380 PMC 바로가기 [Article Type] Research Article

A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

프로테옴 전반에 걸친 유전자 조사는 임상 관련성이 있는 여러 SARS-CoV-2 악용 숙주 표적을 식별합니다.

Research Article

Published on 2021-08-172022-09-10
Journal: eLife
[Category] MERS, SARS, 유전자 메커니즘,

[키워드] ABO Accepted Affect affecting age Alpha analysis Antiviral Apoptosis applied approach approach arising association Author cause CD209 clinical trial contribute COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 phenotypes datasets DC-SIGN death Demographic factors demonstrated disease severity evade explain Factor Factors funding Gender gene expression level gene mutation Genetic genetic colocalization genetic profile healthy individuals help Host host cells host protein host proteins Human identify identifying IL-6R immune immune response individual individuals infect Infection interact Interaction involved Karim MAK mechanism Medical Research Council mendelian randomization minor symptom minor symptoms molecular mutate natural experiment new strain no symptom no symptoms OAS1 open Open Access opens Patient patients with COVID-19 pleiotropic Potential treatment precursor predict predicted Probability PROTECT Protein Proteins proteome provide randomisation reaction receptor receptor protein reduce Research response responsible risk SARS-CoV-2 severe COVID-19 severity of COVID-19 SIGN Spike protein Strains submission susceptibility susceptible susceptible hosts Symptoms target targets the spike protein the strongest Therapeutics treat Treatment Trigger unique unit variety virus virus virus strains viruses Wellcome Trust with COVID-19
[DOI] 10.7554/eLife.69719 PMC 바로가기 [Article Type] Research Article

Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children

소아에서 다기관 염증 증후군의 유전자 발현 네트워크에서 소진된 세포독성 T 세포의 하향 조절

Article

Published on 2021-08-112022-09-10
Journal: Nature Communications
[Category] MERS, SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Antimicrobial responses Author autoimmune pathogenesis Blood blood transcriptome CD56 CD57 CD8 CD8+ T cell Cell cell activation cell type cell types children co-expression Cohort Control coordinator coronavirus COVID-19 patient Cytotoxic T cell disease disease-associated downregulation Fever Gene Expression Genes independent individual Infection Inflammation Inflammatory Kawasaki disease manifestation Manifestations MIS-C multiple organ multiple organs natural killer nine NK cell NK cells Pathogenesis pathology pathway Pathways Patient patients Peripheral blood probe Probing Prognostic markers replicated respiratory reveal RNA sequencing SARS-CoV-2 severe acute respiratory syndrome Coronavirus syndrome Systems analysis T cell T cells TBX21 Transcriptome transcriptome-wide transcriptomes
[DOI] 10.1038/s41467-021-24981-1 PMC 바로가기 [Article Type] Article

Detecting behavioural changes in human movement to inform the spatial scale of interventions against COVID-19

Covid-19에 대한 공간적 규모의 중재를 알리기 위해 인간 운동의 행동 변화 감지

Research Article

Published on 2021-07-122022-09-10
Journal: PLoS Computational Biology
[Category] SARS, 치료기술, 치료제,

Prevalence of neutralising antibodies against SARS-CoV-2 in acute infection and convalescence: A systematic review and meta-analysis

급성 감염 및 회복기에서 SARS-CoV-2에 대한 중화항체의 유병률: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-07-082022-09-12
Journal: PLoS Neglected Tropical Diseases
[Category] Coronavirus, SARS, 진단,

[키워드] 95%CI acute infection adaptive antibodies antibody asymptomatic infection asymptomatic infections Author coronavirus disease correlated correlation covariate covariates cut off detectable develop disease severity elicit examined functional highlight IgG Immunity Immunoglobulin Immunoglobulin G immunoglobulins immunological responses individual infected with SARS-CoV-2 Infection International investigated likelihood lowest marker Meta-analysis Mild Neutralising Antibodies neutralising antibody Patient proportion protocol reference standard reflected respiratory SARS-CoV-2 SARS-CoV-2 antibodies SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 neutralising antibodies SARS-CoV-2 neutralising antibody selected Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus-2 severe coronavirus disease severe COVID-19 study group systematic review titre titres Variation
[DOI] 10.1371/journal.pntd.0009551 PMC 바로가기 [Article Type] Meta-Analysis

Detection of R.1 lineage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with spike protein W152L/E484K/G769V mutations in Japan

스파이크 단백질 W152L/E484K/G769V 돌연변이가있는 R.1 계통 계통 심각한 급성 호흡기 증후군 코로나 바이러스 2 (SARS-COV-2)의 검출

Research Article

Published on 2021-06-072022-08-13
Journal: PLoS Pathogens
[Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter Author Avian Influenza binding domain clade coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detection domain E484K epidemiological escape mutation examined family members genomic GISAID database had no hallmark infected with SARS-CoV-2 Influenza initiative Japan life Lineage lineages MONITOR Mutation mutations N-terminal domain natural selection Nextstrain Novel coronavirus nucleic acid Patient RBD Research respiratory SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 isolate SARS-CoV-2 isolates Sequencing severe acute respiratory syndrome Coronavirus Spike protein spike protein RBD Spike proteins Spread TaqMan the spike protein the United State The United States Transmissibility United States variant variants Viral viral fitness virulence virus strain whole genome Whole genome sequencing Wuhan Wuhan, China
[DOI] 10.1371/journal.ppat.1009619 PMC 바로가기 [Article Type] Research Article

The impact of the COVID-19 pandemic on rabies reemergence in Latin America: The case of Arequipa, Peru

COVID-19 대유행이 라틴 아메리카의 광견병 재발에 미치는 영향: 페루 아레키파의 경우

Research Article

Published on 2021-05-212022-09-10
Journal: PLoS Neglected Tropical Diseases
[Category] SARS, 치료기술,