autoimmune conditions – Page 2 – Communicable Diseases Research

Probiotics in Medicine: A Long Debate

Immunology

Published on 2020-09-252022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS,

[키워드] allergy alveolar amplify approach autoimmune conditions Bacterial Bifidobacterium Central nervous system clinical study Clinical use clinician COVID-19 debate Defense diarrhea Diseases disorder disorders Efficacy and safety Evidence favor gut microbiota Health Host immune system include infections intestinal intestinal epithelium intestine Invasion lactobacillus large sample liver Long lung Macrophage main mechanism Medicine microbiota mucosal occur pandemic Pathogens Pneumonia Population Prevent Probiotics protective role provided reduce reduction Regulation respiratory infection respiratory infections Scientific community Symptom Therapeutic approach therapeutic potential therapy Treatment viral infection viral infections
[DOI] 10.3389/fimmu.2020.02192 PMC 바로가기 [Article Type] Immunology

The C-C Chemokine Receptor Type 4 Is an Immunomodulatory Target of Hydroxychloroquine

Pharmacology

Published on 2020-08-282022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory syndrome antagonist approach autoimmune conditions binding CCR4 Characteristics characterized Chemokine receptor China clinical trial coronavirus COVID-19 COVID-19 patient COVID-19 treatment death demonstrated FDA-approved drug global pandemic Hydroxychloroquine immunomodulation immunomodulatory immunomodulatory activity in silico in vitro Inflammatory interact International involved Ligand malaria Molecular docking study patients potential therapy public health QT prolongation reported Result rheumatoid arthritis risk SARS-CoV-2 SEA similarity subject target therapeutic use Treatment Type Vaccine was selected World Health Organization
[DOI] 10.3389/fphar.2020.01253 PMC 바로가기 [Article Type] Pharmacology

Putative Roles for Peptidylarginine Deiminases in COVID-19

Article

Published on 2020-06-302022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

[키워드] A549 cell lines A549 cells addition alveolar alveolar cell Analysis Anti-viral autoimmune conditions BioProject biopsy bowel cells changes Comorbidities conserved contributing to COVID-19 COVID-19 symptoms disease downregulated elevated enzyme epithelial expression Extracellular extracellular vesicles (EVs) fat Health healthy volunteer highlight Immunity implicated in silico analysis in viral in-host infected cells Infection infections Inflammatory inflammatory pathways isozyme KEGG kidney Kidney injury lung lung epithelial lung tissue mock cells modulation mRNA mRNA level NETosis NHBE organ other tissue PADI1 PADI2 PADI3 PADI4 PADI6 Pathway analysis Patient peptidylarginine deiminases (PADs) phylogenetically Protein protein deimination reduced Regulation response responses reveal role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patients stroke therapeutic target tissue tissue biopsies Transcriptome utilised Variability Variation Vascular Vesicle viral infections
[DOI] 10.3390/ijms21134662 PMC 바로가기 [Article Type] Article

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 치료를 위한 하이드록시클로로퀸의 시험관 내 항바이러스 활성 및 최적화된 투여 설계의 예측

Major Article

Published on 2020-03-092022-09-10
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 비임상,

[키워드] activity acute respiratory syndrome coronavirus advance autoimmune conditions breath China Chloroquine Chloroquine phosphate Concentration coronavirus coronavirus 2 Critically ill cytokine Cytokine storm Dosing dosing regimen drug effective Evidence followed by Hydroxychloroquine hydroxychloroquine sulfate immunomodulatory effect in vitro in vitro data inhibit SARS-CoV-2 Loading dose lung maintenance dose malaria mechanism of action occur pharmacokinetic pharmacological phosphate projection reached regimen respiratory Result safety profile SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread sulfate Support the cytokine storm tolerable treat treating SARS-CoV-2 infection use of hydroxychloroquine Vero cells was tested Wuhan
[DOI] 10.1093/cid/ciaa237 PMC 바로가기 [Article Type] Major Article

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

유전 변이는 점막 염증 질환에서 T-bet 결합 및 유전자 발현을 변경합니다

Research Article

Published on 2017-02-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect alleles Alter alteration Arthritis association autoimmune conditions Autoimmune disease Autoimmune diseases Autoimmunity autoinflammatory disease binding binding site Cancer CD4+ T cell CD4+ T cells celiac disease certainty ChIP ChIP-seq condition contribute Crohn’s disease decreased expression disease disease-associated distal DNA elements environmental factors eQTL examined exons expression expression quantitative trait locus Gene Expression Genetic Genetic polymorphism genetic polymorphisms Genetic variant genetic variants Genetic variation Genome-wide association studies helper cell heterozygous identify IL18RAP immune response in vitro in vivo increased risk individual Infection Inflammatory inflammatory disease Inflammatory diseases Lineage locus majority mechanism modulating molecular mechanism mucosal nucleotide Other polarization polymorphism protective immunity Protein psoriasis Quantitative quantitative trait locus Region regulate Regulatory represse reveal rheumatoid arthritis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs subsequent susceptibility susceptibility to infections T cell T cells T helper cell TBX21 Th1 transcription factor transcription factors transcriptional ulcerative colitis underlie variant
[DOI] 10.1371/journal.pgen.1006587 PMC 바로가기 [Article Type] Research Article

Comprehensive evaluation of medical conditions associated with risk of non-Hodgkin lymphoma using Medicare claims (“MedWAS”)

Article

Published on 2016-04-232024-09-04
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the [Category] 대상포진,

[키워드] autoimmune conditions Human immunodeficiency virus Non-Hodgkin Lymphoma Non-melanoma skin cancer solid organ transplantation
[DOI] 10.1158/1055-9965.EPI-16-0212 PMC 바로가기 [Article Type] Article

Letter to the Editor: Risk factors for second acute myeloid leukemia/myelodysplastic syndrome among survivors of non-Hodgkin lymphoma

Article

Published on 2015-08-282024-09-04
Journal: Leukemia [Category] 대상포진,

[키워드] acute myeloid leukemia autoimmune conditions Chemotherapy infections Myelodysplastic syndrome Non-Hodgkin Lymphoma Radiotherapy
[DOI] 10.1038/leu.2015.248 PMC 바로가기 [Article Type] Article