SARS-CoV-2 infection in pediatric population before and during the Delta (B.1.617.2) and Omicron (B.1.1.529) variants eraArticle Published on 2022-09-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] Affect Asymptomatic available data B.1.1.529 B.1.617.2 caused children clinical manifestation clinical manifestations Complication conditions coronavirus disease country COVID-19 Delta delta variant Direct drastic exacerbating Google Scholar Health highest highlight Hospitalization immune response Immunodepressive incidence Infant Infants infected children Infection Manifestations Mild MIS MIS-C occur omicron Omicron variant pandemic pediatric Prevalence prevalence of COVID-19 proportion reported Risk factors SARS-COV-2 infection Science suggested symptomatic SARS-CoV-2 infection Symptoms the United State Transmission dynamics vaccination variant variants virulent [DOI] 10.1186/s12985-022-01873-4 PMC 바로가기
Clinical course of COVID-19 infection in a melanoma patient treated with nivolumab and bempegaldesleukin: a case report니볼루맙과 베페갈데스류킨으로 치료받은 흑색종 환자의 코로나19 감염 임상 경과: 증례 보고Case Reports Published on 2022-09-012022-09-12 Journal: Immunotherapy [Category] 진단, [키워드] administration available data bempegaldesleukin cancer patient Case report clinical Clinical characteristics Combination Course COVID-19 COVID-19 infection Cytokines IL-2 Immune checkpoint inhibitor immune-related pneumonitis Immunotherapy Laboratory mechanism of action Melanoma nivolumab nivolumab. outcome Patient Pneumonia treated Treatment [DOI] 10.2217/imt-2021-0331 PMC 바로가기 [Article Type] Case Reports
COVID-19 vaccination, incidence, and mortality rates among indigenous populations compared to the general population in Brazil: Describing trends over timeResearch article Published on 2022-09-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 진단, [키워드] absence Adults age available data Brazil chronic Coverage COVID-19 COVID-19 incidence COVID-19 pandemic COVID-19 vaccination cumulative cumulative mortality death decrease Describing detrimental Effectiveness extreme finding funding General population health inequities Health inequity heterogeneity implementation incidence incidence rate incidence rates Indigenous populations information Isolation Ministry of Health Mortality mortality rate Older Population populations regions reported resource respond supported the vaccine Trends over time vaccination Vaccination strategy Vaccine [DOI] 10.1016/j.lana.2022.100319 [Article Type] Research article
SARS-CoV-2 genomic epidemiology: data and sequencing infrastructureSARS-CoV-2 게놈 역학: 데이터 및 시퀀싱 인프라Article Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] available data computation country COVID-19 case Critical develop Epidemiology funds genomic Genomic surveillance identify implementation Influenza initiative lack Low- and middle-income countries mobilization molecular Molecular epidemiology Next-generation sequencing next-generation sequencing platforms Outbreaks Oxford Nanopore MinION platform SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 sequencing Sequencing significantly higher Support Surveillance viral lineages whole-genome whole-genome sequencing [DOI] 10.2217/fmb-2021-0207 PMC 바로가기 [Article Type] Article
Seroprevalence of SARS-CoV-2 on health professionals via Bayesian estimation: a Brazilian case study before and after vaccines베이지안 추정을 통한 의료 전문가에 대한 SARS-CoV-2의 혈청 유병률: 백신 전후의 브라질 사례 연구Article Published on 2022-09-012022-09-12 Journal: Acta tropica [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age analyzed Antibody test available data Bayesian Bayesian analysis Bayesian inference Brazil Characteristics conducted COVID-19 COVID-19 infection databases ELISA Europe Health IgA IgG IgG antibody increase in information knowledge Local Metrics multiple scenario Older pandemic Population presence of comorbidity professional provided regions SARS-CoV-2 SARS-CoV-2 antibody Scientific community sensitivity Serological diagnosis Seroprevalence Sex specificity Stratification study population subject Support the median USA vaccination Vaccine [DOI] 10.1016/j.actatropica.2022.106551 PMC 바로가기 [Article Type] Article
Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts에센셜 오일 및 방향족 추출물의 anti-SARS-CoV-2 특성 평가Article Published on 2022-08-202022-09-11 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] anti-SARS-CoV-2 Antiviral available data Coronaviruses COVID-19 outbreak develop Effectiveness Essential exploratory study growth highly pathogenic human coronavirus inhibitory knowledge long term Papain Papain-like protease protease inhibitors Proteases SARS-CoV-2 therapeutic strategy [DOI] 10.1038/s41598-022-18676-w PMC 바로가기 [Article Type] Article
Safety and immunogenicity following a homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a secondary analysis of a randomised, placebo-controlled, phase 2 trialClinical Trial Published on 2022-08-102022-10-06 Journal: The Lancet. Infectious Diseases [Category] SARS, 변종, 진단, [키워드] 1:1 Administered administration adverse event adverse events age amplifying analysed Analysis antibody concentration Antigen assigned available data BMI booster booster dose Breastfeeding Coalition Contraception COVID-19 pandemic diagnosis of COVID-19 dose Efficacy enrolled evaluated event Evidence exclusion geometric mean titre GMT group healthy homologous IgG immune response inactive increase in initial intramuscular Local Matrix-M median Medical conditions Novavax NVX-CoV2373 outcome participant per-protocol per-protocol population phase 2 trial phase 3 study Placebo placebo-controlled pregnant primary endpoint proportion Protein randomisation randomised Randomly reaction reactogenicity receive Recombinant spike protein recruited regimens Registered Safety SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant screened serum IgG single booster dose stratified Support the SARS-CoV-2 the vaccine titres Treatment Trial USA vaccination Vaccine variant were excluded women [DOI] 10.1016/S1473-3099(22)00420-0 PMC 바로가기 [Article Type] Clinical Trial
Assessing and improving the validity of COVID-19 autopsy studies – A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analysesResearch article Published on 2022-08-022022-10-05 Journal: EBioMedicine [Category] Coronavirus, SARS, 치료기술, [키워드] Alliance Analysis antibody approach Assessing Autopsy autopsy study available data Berlin cell line cellular structure center correlated COVID-19 criteria education Effect Effects electron microscopy evaluated finding foundation funding Guidance help high variability highest IHC immune response immunohistochemistry Interpretation Microscopy Ministry of Health multicentre organ organ damage pathology pathophysiology positive correlation Protein provided Quantitative recommendation reproducibility RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleocapsid SARS-CoV-2 viral RNA Sensitivity and specificity specificity the SARS-CoV-2 tissue tissues university Validity Variability Viral protein virus [DOI] 10.1016/j.ebiom.2022.104193 [Article Type] Research article
Role of therapeutic plasma exchange in the management of COVID-19-induced cytokine storm syndromeReview article Published on 2022-08-012022-10-05 Journal: Transfusion and apheresis science : official journ [Category] SARS, 바이오마커, 임상, 치료제, [키워드] member 13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif acute respiratory syndrome ADAMTS-13a disintegrin and metalloproteinase with a thrombospondin type 1 motif American Society for Apheresis approach ARDSacute respiratory syndrome article ASFAAmerican Society for Apheresis available data benefit C-reactive protein Case series Case-control CCPCOVID-19 convalescent plasma Clinical outcome Coagulopathy conducted Controlled clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma COVID-19coronavirus disease 2019 criteria Critically ill patient CRPC-reactive protein CSS CSScytokine storm syndrome Cytokine storm syndrome Cytokines D-dimer Effects Evidence excessive immune response feasibility ferritin FFPfresh frozen plasma fibrinogen level fresh frozen plasma hypercoagulable Hyperinflammatory ICUIntensive Care Unit identify IFNinterferon ILInterleukin immunomodulatory effect improvement Inflammatory factor intensive care unit interferon interleukin interleukin-6 Intervention Length of stay LOSlength of stay Lymphocyte count macrophage activation syndrome management MASmacrophage activation syndrome MODSmultiple organ dysfunction syndrome Mortality multiple organ dysfunction syndrome offer offset PaO2:FiO2pressure of arterial oxygen to fractional inspired oxygen concentration pathologic Patient patients patients with COVID-19 peer-reviewed potential clinical benefits pressure of arterial oxygen to fractional inspired oxygen concentration prevent disease progression Randomized Randomized controlled trial RCTrandomized controlled trial reduce reduce mortality resulting risk role Safe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 secondary hemophagocytic lymphohistiocytosis selected Sequential Organ Failure Assessment severe acute respiratory syndrome coronavirus 2 sHLHsecondary hemophagocytic lymphohistiocytosis SOFASequential Organ Failure Assessment TAMOFthrombocytopenia-associated multiple organ failure Therapeutic plasma exchange thrombocytopenia-associated multiple organ failure TNFTumor Necrosis Factor TPE TPEtherapeutic plasma exchange treat Treatment tumor necrosis factor while with COVID-19 [DOI] 10.1016/j.transci.2022.103433 [Article Type] Review article
Possible Role of Matrix Metalloproteinases and TGF-β in COVID-19 Severity and SequelaeCOVID-19 중증도 및 후유증에서 기질 금속단백분해효소 및 TGF-β의 가능한 역할Review Published on 2022-08-012022-09-11 Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 analyzed Antiviral agents ARDS available data Biomarker Biomarkers Clinical features clinical form complex interplay convalescence convalescent COVID-19 patients coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 pathogenesis cytokine Cytokines death Diagnosis ECM elicited exacerbated Extracellular matrix Factor fibrosis growth hallmark immune response immune responses Immunity immunological implication Infection Inflammation knowledge Lungs mandatory Manifestations matrix matrix metalloproteinase matrix metalloproteinases MMPs molecular other respiratory infection other respiratory infections paradox Participation pathobiology of COVID-19 Prognosis provide pulmonary fibrosis reduce remark required Research respiratory respiratory infections role SARS-CoV-2 sequela serological Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe COVID-19 TGF-β the disease therapeutic target therapeutic targets therapy tissue injury transforming growth factor Treatment wound healing [DOI] 10.1089/jir.2021.0222 PMC 바로가기 [Article Type] Review