Evaluation of Metagenomic and Targeted Next-Generation Sequencing Workflows for Detection of Respiratory Pathogens from Bronchoalveolar Lavage Fluid Specimens기관지폐포 세척액 표본에서 호흡기 병원체 검출을 위한 메타게놈 및 표적 차세대 시퀀싱 워크플로 평가Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antimicrobial resistance applied approach approaches automated Bacteria BAL bioinformatic analysis Bronchoalveolar lavage carbapenem complementary complex coronavirus cytomegalovirus defined demonstrated detection diagnostics ENhance evaluated house Illumina in some Inc. lavage less Lower respiratory tract lower respiratory tract infection marker metagenomic Next-generation sequencing NGS nonpathogenic Organisms pathogen Pathogens phenotypic positive Pseudomonas aeruginosa reagent reagents replacement required respiratory Respiratory pathogens respiratory tract infection rhinovirus sequence Sequencing severe acute respiratory syndrome Coronavirus specimen standardized criteria Ureaplasma [DOI] 10.1128/jcm.00526-22 PMC 바로가기 [Article Type] Article
A 51-Year-Old Woman With Interstitial Lung Disease and Subsequent COVID-19 Presenting With Worsening DyspneaCase report Published on 2022-07-062022-10-05 Journal: Chest [Category] 변종, 유전자 메커니즘, [키워드] airway BAL bronchoscopy Care Chest CT COVID-19 cultures defined Diagnosis diffusing Dyspnea foamy macrophage foamy macrophages functional ground-glass opacity Hospitalization Hospitalized ILD impairment Inconclusive interlobular septal thickening Interstitial lung disease intralobular lung Lung disease Mild Moderate COVID-19 Patient presentation presenting Pulmonary function testing Result Shortness of breath specimen table transbronchial transfer video-assisted thoracoscopic surgery woman worsening [DOI] 10.1016/j.chest.2022.01.059 [Article Type] Case report
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine나노입자 전달 TLR4 및 RIG-I 작용제는 SARS-CoV-2 소단위 백신에 대한 면역 반응을 향상시킵니다Article Published on 2022-07-012022-09-11 Journal: Journal of controlled release : official journal o [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activated Adaptive immune response adjuvant adjuvants agonist Anti-spike anti-Spike IgG Antibody titer Antibody titers Antigen antigen-presenting cell antigen-presenting cells APC APCS B cell B cells BAL Bcl6 Blood bronchoalveolar CD4 CD44 Cell cell population characterized Combination adjuvant COVID-19 COVID-19 protein subunit vaccine CpG DLNs draining lymph node draining lymph nodes Efficacy ENhance follicular Germinal center GL7 helper cell humoral immune responses IgA IgG immune immune response immune responses Immunity IMPROVE in vitro in vivo Increases increases in Infection intramuscular intramuscular vaccination intranasal Intranasal versus intramuscular vaccination intranasally lead lung Lungs lymphocyte memory T memory T cell mice molecular Monophosphoryl lipid A MPLA Native neutralizing antibody titers Pattern recognition pattern recognition receptor Pattern recognition receptors Polymer Population Proinflammatory cytokine Protein subunit protein subunit vaccine Protein subunit vaccines PRR PRRs PUUC reaction receptor receptors responses against retinoic acid retinoic acid-inducible gene I RIG-I robust S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein secretion spike IgA Spike protein stabilized spike protein stimulate subunit Subunit vaccine T cell T cell proliferation the S1 subunit TLR TLR4 TLR7 TLR7/8 TLR9 TLRs Toll-like receptor Toll-like receptors Transmission unique Vaccine vaccine availability vaccine responses variants [DOI] 10.1016/j.jconrel.2022.05.023 PMC 바로가기 [Article Type] Article
Tracheal Aspirate and Bronchoalveolar Lavage as Potential Specimen Types for COVID-19 Testing Using the Cepheid Xpert Xpress SARS-CoV-2/Flu/RSVCepheid Xpert Xpress SARS-CoV-2/Flu/RSV를 사용한 COVID-19 검사를 위한 잠재적 표본 유형으로서의 기관 흡인 및 기관지폐포 세척Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] addition anticipated approved aspirate BAL Bronchoalveolar lavage bronchoalveolar lavage sample bronchoalveolar lavage samples Cepheid community transmission COVID-19 criteria Cycle threshold values Diagnosis diagnostic test evaluated Evidence help hospital implication Influenza influenza A influenza B lab lavage Lower respiratory tract lower respiratory tract specimen management multiplex overcome Patient PCR test performance platform point of care positive Potential Precision provide Rapid diagnostic test reproducibility respiratory respiratory specimen respiratory syncytial virus SARS-CoV-2 SARS-CoV-2 detection specimen specimens target tested Testing the SARS-CoV-2 tracheal Type upper respiratory tract Xpert Xpress SARS-CoV-2 assay [DOI] 10.1128/spectrum.00399-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes중환자 COVID-19 환자의 폐실에서 SARS-CoV-2 바이러스 부하가 바이러스 혈청 부하 및 치명적인 결과와 상관관계Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] association BAL Blood bronchoalveolar Bronchoalveolar lavage clinical Clinical data Clinical outcome clinical outcomes compartment contribute copy number correlation COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical care Critically ill Critically ill patient critically ill patients Croatia diagnostic disease elevated highest hospital ICU admission Ill intensive care intensive care unit load Lower respiratory tract lung Lungs mechanical ventilation support outcome outcomes pandemic parameter Predictive Prognostic value pulmonary qPCR quantification quantified SARS-CoV-2 SARS-CoV-2 detection serum sample serum samples sputum survival Swab swabs upper respiratory tract Viral load viral load analysis viral loads Virus quantification virus titers while [DOI] 10.3390/v14061292 PMC 바로가기 [Article Type] Article
Identification of bronchoalveolar and blood immune-inflammatory biomarker signature associated with poor 28-day outcome in critically ill COVID-19 patients중환자 COVID-19 환자에서 좋지 않은 28일 결과와 관련된 기관지 폐포 및 혈액 면역 염증 바이오마커 식별Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission assays BAL BAL fluid BALF Biological biological profile biomarker signature Blood blood concentration bronchoalveolar Bronchoalveolar lavage Characteristics clinical Clinical outcome Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine defined described eicosanoid Eicosanoids elicited ELISA endothelial injury exhibited fiberoptic bronchoscopy Health Organization identification IFN-γ IL-10 IL-22 IL-5 IL-6 Infection Inflammatory response intensive care intensive care unit interferon Local metabolomic analysis neutrophil outcome Patient performed phenotype respiratory SARS-CoV-2 scale severe acute respiratory syndrome Coronavirus type I interferon Vascular Vasoactive VEGF WHO-CPS World Health Organization [DOI] 10.1038/s41598-022-13179-0 PMC 바로가기 [Article Type] Article
Lung targeted liposomes for treating ARDSARDS 치료를 위한 폐 표적 리포솜Article Published on 2022-06-012022-09-11 Journal: Journal of controlled release : official journal o [Category] 치료제, [키워드] accumulate accumulation acute respiratory distress acute respiratory distress syndrome Administered administration alveolar approach ARDS BAL Bronchoalveolar lavage C57BL/6 characterized combined treatment COPD COVID-19 COVID-19 infections cysteine cytokine secretion distal DPPC drug Efficiency encapsulation endotracheal exhibited Gas exchange Hypoxemia IL-1β IL-6 impair infections Inflammation Inflammatory marker inflammatory markers intravenous intravenously lipid composition Lipid nanoparticles lipopolysaccharide Liposome lung lung damage Lung diseases lung disorders lung endothelial lung epithelial Lung inflammation Lungs Macrophage macrophages marker medication Methylprednisolone mice mortality rate mortality rates MPS mucolytic agent Mucus N-acetyl cysteine NAC nanoparticle Nanotechnology nitric oxide outcome Patient penetration provided pulmonary reached reduce reducing Region respiratory respiratory distress Respiratory distress syndrome secretion steroid syndrome therapeutic therapeutic effect therapeutic efficacy TNFα Treatment Treatment outcome were assessed [DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
Diagnosing COVID-19; towards a feasible COVID-19 rule-out protocolCOVID-19 진단; 실현 가능한 COVID-19 배제 프로토콜을 향해Article Published on 2022-04-012022-09-11 Journal: Acta clinica Belgica [Category] COVID19(2023년), SARS, 치료기술, [키워드] added Analysis antibody Antibody testing approach BAL BAL fluid bronchoalveolar Bronchoalveolar lavage bronchoscopy Chest CT COVID-19 COVID-19 in patient COVID-19 negative COVID-19 positive patients Critically ill Culture decrease diagnoses diagnostics etiological agent feasible Ghent identify IgA IgG implementation initial invasive low-dose microbial multiplex Multiplex PCR negativity non-critically ill patient Pathogens Patient positive protocol repeated respiratory pathogen Retrospective analysis rRT-PCR RT-PCR SARS-CoV-2 SARS-COV-2 infection selected Serological assay serological assays serology Symptom university [DOI] 10.1080/17843286.2021.1883362 PMC 바로가기 [Article Type] Article
Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2SARS-CoV-2 S 단백질을 발현하는 폭스바이러스 MVA는 강력한 면역을 유도하고 SARS-CoV-2로부터 붉은털원숭이를 보호합니다Article Published on 2022-03-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] BAL Bronchoalveolar lavage caused Cell clinical trials Computed tomography COVID-19 COVID-19 pandemic cytokine Cytokine storm domain effective vaccine Effective vaccines Efficacy elicited expressing favor Fever full-length SARS-CoV-2 histological histological examination IFNγ IgG antibodies IgG antibody IL-4 immunogenic immunogenicity lung Lung pathology Lungs macaque macaques modified vaccinia virus MVA vaccine nasal mucosa Neutralizing antibodies neutralizing antibody novel Protein Receptor-binding domain reduced reduction rhesus rhesus macaque rhesus macaques robust Safe Safety SARS-CoV-2 SARS-CoV-2 S several variant several variants spike tomography vaccination Vaccine virus load [DOI] 10.3389/fimmu.2022.845887 PMC 바로가기 [Article Type] Article
A systematic review and metanalysis of diagnostic yield of BAL for detection of SARS-CoV-2SARS-CoV-2 검출을 위한 BAL 진단율의 체계적인 검토 및 메타분석Review Published on 2022-03-012022-09-11 Journal: Heart & lung : the journal of critical care [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BAL Bronchoalveolar lavage can be used Chain Reaction coronavirus COVID-19 COVID-19 diagnostic testing [Supplementary Concept] database databases diagnose diagnosing diagnostic diagnostic testing disease duplicate eligibility false false-negative for inclusion gold gold standard Google Scholar Infection initial item Lower respiratory tract lower respiratory tract infection Nasopharyngeal swab nasopharyngeal swabs Oropharyngeal Patient primary disease PRISMA Prospective Registered registry Reporting respiratory tract infection reverse transcriptase reverse transcriptase-polymerase chain reaction review risk of bia robust RT-PCR SARS-CoV-2 SARS-CoV-2 positivity screened searched sensitivity analysis severe acute respiratory syndrome Coronavirus severe COVID-19 systematic review systematic reviews upper respiratory tract [DOI] 10.1016/j.hrtlng.2021.11.011 PMC 바로가기 [Article Type] Review