Nasopharyngeal Bacterial Microbiota Composition and SARS-CoV-2 IgG Antibody Maintenance in Asymptomatic/Paucisymptomatic Subjects무증상/무증상 피험자의 비인두 세균성 미생물총 구성 및 SARS-CoV-2 IgG 항체 유지 관리Article Published on 2022-07-062022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Analysis anti-RBD antibody Asymptomatic Asymptomatic carriers Bacterial best cause characterized condition coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 enrolment Evidence IgG antibody immune response immunoglobulins Immunological memory Infection influence investigated knowledge Lung injury maintenance mechanism microbiota multi-organ failure nasopharyngeal nasopharyngeal bacterial microbiota. Nasopharyngeal swab Odds ratio performed positive positive serology predict Regulation respiratory respiratory infection respiratory infections SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 infections SARS-CoV-2 RNA serum severe acute respiratory syndrome Coronavirus severity subject tested UNICORN Viral viral entry viral infections [DOI] 10.3389/fcimb.2022.882302 PMC 바로가기 [Article Type] Article
CRISPR-based assays for rapid detection of SARS-CoV-2SARS-CoV-2의 신속한 검출을 위한 CRISPR 기반 분석Review Published on 2022-07-012022-09-11 Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] best COVID-19 CRISPR CRISPR Diagnostics diagnosis of SARS-CoV-2 Diagnostic advancements diagnostic test diagnostic tests diagnostics effective effort Epidemiology Establishing global public health gold gold standard healthy individual healthy individuals infected patient Instrumentation isothermal limitation molecular testing nucleic acid nucleic acids overcome pandemic quarantine reagent reagents required SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2. serological test Serological tests the disease Treatment while [DOI] 10.1016/j.ymeth.2020.10.003 PMC 바로가기 [Article Type] Review
Diagnosis and prognosis of COVID-19 employing analysis of patients’ plasma and serum via LC-MS and machine learningLC-MS 및 머신러닝을 통한 환자의 혈장 및 혈청 분석을 통한 코로나19 진단 및 예후Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, [키워드] Accuracy acetyl Algorithm Analysis analyzed best Biomarker Biomarkers caused China controls COVID COVID 19 COVID-19 COVID-19 diagnosis COVID-19 patient datasets Diagnosis evaluate evaluated fatality glucosamine greater healthy volunteer healthy volunteers help hospital independent l-ornithine LC-MS machine machine learning material metabolite methyl isobutyrate negative RT-PCR outcomes Patient patients with COVID-19 patients with pneumonia phosphate plasma Pneumonia predict Prognosis prognostic indicator RT-PCR Sample SARS-CoV-2 serum severity Severity. significantly SVM the disease uridine virus viruses were used with COVID-19 [DOI] 10.1016/j.compbiomed.2022.105659 PMC 바로가기 [Article Type] Article
Circulating suPAR associates with severity and in-hospital progression of COVID-19순환하는 suPAR은 COVID-19의 중증도 및 병원 내 진행과 관련이 있습니다.Observational Study Published on 2022-07-012022-09-11 Journal: European Journal of Clinical Investigation [Category] MERS, 바이오마커, 임상, [키워드] 95% CI Accuracy Admission Adult patients age albumin assays association AUC best characterized clinical correlated COVID-19 COVID-19 disease CRP discrimination Disease progression disease severity doubling EGFR ELISA females ferritin FIVE Hospital admission hyperinflammation IMPROVE In-hospital interleukin interleukin-6 International Lactate lactate dehydrogenase LDH Linear model male marker median age observational study outcome parameter patients patients hospitalized plasma suPAR predict primary outcome measure procalcitonin progression risk stratification scale serum albumin serum lactate severity severity of COVID-19 significantly significantly lower suPAR suPAR. survival survivor Treatment WHO WHO Clinical Progression Scale WHO-CPS [DOI] 10.1111/eci.13794 PMC 바로가기 [Article Type] Observational Study
Cost-Effectiveness Analysis of Molnupiravir Versus Best Supportive Care for the Treatment of Outpatient COVID-19 in Adults in the US미국 성인의 코로나19 외래환자 치료를 위한 몰누피라비르 대 최상의 지지 요법의 비용 효율성 분석Article Published on 2022-07-012022-09-11 Journal: PharmacoEconomics [Category] MERS, 바이오마커, 변종, [키워드] acute phase adult outpatient adult outpatients Adult patients affected Analysis Antiviral best Care changes changes in conducted coronavirus disease Coronavirus disease 2019 Cost effectiveness COVID-19 COVID-19 outpatients database de novo Decision tree decrease died dominant effective Electronic health record Electronic health records evaluated healthcare Healthcare system highest Hospitalization Hospitalized Immunity increase in information Intervention less Markov medical costs Mild-to-moderate molnupiravir outcome Outpatient pandemic parameter Patient patient population Perspective Primary outcomes Probability progression proportion real-world data reduction remained reported Research risk sensitivity analysis severe disease Society supportive care Therapies threshold transition transition probabilities treated treating COVID-19 Treatment Trial unavailability utility vaccination Viral Viral variants with COVID-19 [DOI] 10.1007/s40273-022-01168-0 PMC 바로가기 [Article Type] Article
Reduced neutralizing antibody potency of COVID-19 convalescent vaccinated plasma against SARS-CoV-2 Omicron variantSARS-CoV-2 오미크론 변이체에 대한 COVID-19 회복기 백신 접종 혈장의 중화 항체 효능 감소Article Published on 2022-07-012022-09-11 Journal: Vox Sanguinis [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] anti-IgG Anti-S1 antibody assays B.1 best binding coefficient collected convalescent convalescent plasma correlated correlation coefficient COVID-19 D614G Donor fraction highest IgG IgG level Immunocompromised patient Immunocompromised patients Infection median Mutation NAb Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant plasma Quantitative reduced relationship resulting SARS-CoV-2 selected significantly lower Spearman Strains threshold titre titres vaccination vaccination. variant [DOI] 10.1111/vox.13279 PMC 바로가기 [Article Type] Article
Exposing and Overcoming Limitations of Clinical Laboratory Tests in COVID-19 by Adding Immunological Parameters; A Retrospective Cohort Analysis and Pilot Study면역학적 매개변수를 추가하여 COVID-19에서 임상 실험실 테스트의 한계를 노출하고 극복합니다. 후향적 코호트 분석 및 파일럿 연구Article Published on 2022-06-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] acute phase acute phase reactants Adding adopted age Alanine alanine aminotransferase Algorithm Analysis aspartate Aspartate aminotransferase association Barcelona best Biomarker C-reactive protein category CCL2 chemokines classical clinical clinical and laboratory variables clinical laboratories clinical laboratory clinical laboratory tests Clinical management clinical parameter Clinical parameters clinical variable clinical variables Cohort collected Comorbidity conducted COVID 19 patient COVID 19 patients COVID-19 COVID-19 pandemic COVID-19 patient CXCL10 cytokine Cytokines exploratory feasible fibrinogen filtration rate First wave flow cytometry fraction glomerular filtration rate IL-1ra IL-6 immune response immunological Immunological test immunological tests IMPROVE independent Inflammation Interpretation Laboratory Laboratory test Laboratory tests limitation lymphocyte neutrophil organ organ damage outcome overcome oxygen oxygen saturation pandemic patients performed phenotype pilot study Predictive predictive power predictive risk-profile. predictor Prognosis redundancy reflected SARS-CoV-2 SARS-COV-2 infection severity statistical statistical analysis survival Test two subgroup two subgroups understanding validation cohort validation cohorts variable [DOI] 10.3389/fimmu.2022.902837 PMC 바로가기 [Article Type] Article
Superimmunity by pan-sarbecovirus nanobodies범사르베코바이러스 나노바디에 의한 초면역Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] activities against SARS-CoV best booster breadth broadly neutralizing nanobody camelid clade conserved correlated CP: Immunology distance domain effective epitope Epitopes Evolution facilitate FIVE flat flexible Immunity immunized immunology Infection inhalable bispecific nanobody PiN-31 mechanism median milliliter nanobody neutralization potency Neutralizing observé omicron pan-sarbecovirus neutralization proteomics RBD RBD surface Receptor binding residues sarbecovirus SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 spike SARS-CoV-2 variants super immunity. the SARS-CoV-2 V(H)H antibody [DOI] 10.1016/j.celrep.2022.111004 PMC 바로가기 [Article Type] Article
The influence of time on the sensitivity of SARS-CoV-2 serological testingSARS-CoV-2 혈청 검사의 민감도에 대한 시간의 영향Article Published on 2022-06-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] 95% CI Abbott anti-SARS-CoV-2 antibodies Antibody titer Antibody titers approach assays best booster vaccination collected Course days post infection demonstrated detect detectable diagnostic diagnostic sensitivity Elecsy evaluated Evidence evidence of follow-up period immune correlate immune correlates infected with SARS-CoV-2 Infection limitation long-lasting median Meso Scale Discovery MSD natural infection Neutralizing no evidence of nucleoprotein occurred Patient performed positive Probability proportion provide Quantitative Roche SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody sensitive sensitivity serological test Serological testing Serological tests shown spike Spike protein Support survival survival time symptom onset the spike protein therapy time-to-event analysis Treatment [DOI] 10.1038/s41598-022-14351-2 PMC 바로가기 [Article Type] Article
Death and invasive mechanical ventilation risk in hospitalized COVID-19 patients treated with anti-SARS-CoV-2 monoclonal antibodies and/or antiviral agents: A systematic review and network meta-analysis protocol항SARS-CoV-2 단클론항체 및/또는 항바이러스제로 치료받은 입원한 COVID-19 환자의 사망 및 침습적 기계 환기 위험: 체계적인 검토 및 네트워크 메타 분석 프로토콜Article Published on 2022-06-172022-09-11 Journal: PLoS ONE [Category] MERS, meta-analysis, 변종, 진단, 치료제, [키워드] (risk ratio 95% confidence interval acceptance Analysis anti-SARS-CoV-2 Antiviral Antiviral agents approach assessment assumption best claimed Comorbidities confidence COVID-19 pandemic COVID-19 patient Critically ill cumulative death development diagnosed effect size Evidence high risk hospitalized COVID-19 patient hospitalized patient hospitalized patients Immunocompromised indicate intensive care intensive care unit Intervention Invasive mechanical ventilation Local meta-analysis monoclonal antibody Mortality network Network meta-analysis NMA nucleic acid nucleic acid amplification nucleic acid amplification test occur occurred outcome Patient plan PROSPERO protocol Randomized controlled trial Randomized controlled trials randomized trial randomized trials Registration reported risk risk of bia risk of infection risk ratio RoB 2 sensitivity analysis Stata Statistical Software statistical statistical significance Steroids systematic review treated Trial variants variants of concern [DOI] 10.1371/journal.pone.0270196 PMC 바로가기 [Article Type] Article