Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 ReplicationArticle Published on 2022-02-042022-10-30 Journal: Molecules [Category] COVID-19, COVID19(2023년), SARS, [키워드] 1-heteroaryl-2-alkoxyphenyl analogs 1,2,4-oxadiazole active against acute respiratory syndrome addition antiviral drugs beta-coronavirus can be used conducted coronavirus COVID-19 demonstrated effort experiment identify pandemic Profiling public health replaced SAR SARS-CoV-2 subsequent synthesis Vaccines viral entry yielding [DOI] 10.3390/molecules27031052 PMC 바로가기 [Article Type] Article
Immune interventions in COVID-19: a matter of time?COVID-19에 대한 면역 개입: 시간 문제입니까?Review Published on 2022-02-012022-09-11 Journal: Mucosal Immunology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] administration animal model animal models Antiviral strategies antiviral strategy available data beta-coronavirus clinical trial clinical trials COVID-19 pandemic discrepancies dysregulated immune response Effect effective Efficacy Frame heterogeneity hyperinflammation immune immune response immunosuppressive drug Infection infections Intervention Kinetics lack Patient Pneumonia reactive required severe COVID-19 the timing Time frame timepoint tissue lesion tissue lesions Treatment [DOI] 10.1038/s41385-021-00464-w PMC 바로가기 [Article Type] Review
Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune ResponseCOVID-19 환자의 혈장에서 회수된 엑소좀은 SARS-CoV-2 스파이크 유래 단편을 노출시키고 적응 면역 반응에 기여합니다Immunology Published on 2022-01-172022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] acute phase acute respiratory syndrome antigen-presenting cells (APCs) beta-coronavirus caused CD4 chronic inflammation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathology COVID-19 patient COVID-19 patients Exosome Exosomes Extracellular extracellular vesicle fragment globe immune activation immune response immune system immunomodulatory molecules Infectious disease Patient performed plasma Protein proteome recovered reflect response SARS-CoV-2 soluble mediators in immunity spike-derived peptide Spread T-cell responses the disease vector Vesicle viral infection [DOI] 10.3389/fimmu.2021.785941 PMC 바로가기 [Article Type] Immunology
Evaluation of neutralizing antibodies after vaccine BNT162b2: Preliminary data백신 BNT162b2 후 중화 항체 평가: 예비 데이터Article Published on 2022-01-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome age antibody antibody levels Antibody test appear beta-coronavirus binding BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine carried caused complex coronavirus disease Coronavirus disease 2019 declined detect DiaSorin evaluated female participants female subjects FIVE followed by healthcare humoral immune response IgG IgG antibodies IgG antibody immune immunisation Immunisation safety immunogenicity data increase in individuals infected with SARS-CoV-2 male participant male subject male subjects mean value Neutralizing antibodies neutralizing antibody no significant difference outbreak pandemic plateau reached Receptor binding domain reported respiratory SARS-CoV-2 second dose seronegative Serum level serum levels significant difference statistically significant Surveillance the mean the vaccine two subject Two subjects vaccination Vaccine were infected Wuhan Wuhan, China [DOI] 10.1016/j.jcv.2021.105057 PMC 바로가기 [Article Type] Article
Giant compressive emphysema: a rare complication of COVID-19Case Report Published on 2021-12-302022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antibiotic therapy association beta-coronavirus chronic obstructive Comorbidities complication of COVID-19 coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Critical CT scan curative described Diagnosis dose emphysema evaluate Giant had no Hospitalization Hospitalized ipsilateral lung lung involvement Manifestations oxygen Oxygen therapy Pain Patient Physical examination Pneumonia Prognosis pulmonary disease pulmonary involvement pulmonary parenchyma responsible RNA SARS-CoV-2 severity Structure subject the patient Thoracic Thoracic CT scan tympany was performed worldwide pandemic [DOI] 10.1186/s12879-021-07006-6 PMC 바로가기 [Article Type] Case Report
Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years15 년 후 면역 상태 및 폐 기능에 대한 SARS-COV 감염의 영향에 대한 조사Research Published on 2021-11-242022-09-01 Journal: BMC Infectious Diseases [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] Abnormalities abnormality airway Analysis benefit beta-coronavirus caused Chest CT Complete components coronavirus detect disease onset dysfunction Effect ELISA enrolled Epidemic evaluated globin healthcare worker HRCT IgG antibodies IgG antibody immune function immune memory immune system immune systems investigation lung lung damage Lung function mMRC N protein non-severe group Post-infection Protein Pulmonary function test Pulmonary function tests pulmonary rehabilitation RBD protein Regulatory T cell Result S-RBD SARS-CoV SARS-CoV infection SARS-CoV specific IgG antibody SARS-CoV-2 pandemic sera Serum level Severe acute respiratory syndrome (SARS) severe group specific IgG antibodies subgroup analysis subject subjects Survivors T cell T regulatory cell T regulatory cells Trial registration university was used were infected [DOI] 10.1186/s12879-021-06881-3 PMC 바로가기 [Article Type] Research
Understanding COVID-19: From Dysregulated Immunity to Vaccination Status QuoImmunology Published on 2021-11-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV acute respiratory syndrome animal models beta-coronavirus coronavirus coronavirus disease COVID-19 cross death dysregulated immune response etiological agent experimental model experimental models immune responses Infectious disease Novel viruses Personalized medicine public health SARS-CoV-2 status understanding Vaccine Vaccine development [DOI] 10.3389/fimmu.2021.765349 PMC 바로가기 [Article Type] Immunology
Coronavirus Nsp1: Immune Response Suppression and Protein Expression InhibitionMicrobiology Published on 2021-09-282022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] beta-coronavirus coronavirus Coronaviruses COVID-19 pandemic deaths expression gene expression level Host host cells Host immune response host protein immune response Immune suppression inhibition live-attenuated vaccine mechanisms Mutation nonstructural protein 1 pathogenicity Protein protein synthesis public health reduce response SARS-CoV-2 suppresse suppression translation translation inhibition unique Vaccine Viral proteins Viral RNA virus [DOI] 10.3389/fmicb.2021.752214 PMC 바로가기 [Article Type] Microbiology
Analysis of the molecular mechanism of SARS-CoV-2 antibodiesSARS-CoV-2 항체의 분자 메커니즘 분석Review Published on 2021-08-202022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibody antibody cocktail beta-coronavirus binding domain binding epitope caused Chinese death effective epitope Epitopes human cells include infect Infection mechanism molecular mechanism monoclonal antibodies monoclonal antibody neutralize Neutralizing activity NTD pandemic provide RBD Receptor binding domain receptor binding domain (RBD) Region reported Research respiratory Respiratory disease S protein S proteins SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 mutants Spike proteins TCM the antibody the S protein the SARS-CoV-2 the spike protein therapy Traditional Chinese medicine Treatment treatment strategy Vaccine vaccine therapy WHO [DOI] 10.1016/j.bbrc.2021.06.001 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Infection and Guillain-Barré SyndromeReview Published on 2021-07-242022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute respiratory syndrome Autoimmune disease beta-coronavirus cause caused characterized condition coronavirus COVID-19 COVID-19 illness diabetes disease Guillain-Barré syndrome Guillain–Barrè syndrome Headaches higher risk loss of taste lung medical condition Mild Neurological complication neurological deficits neurological manifestation outbreak pandemic SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 infection severe complication syndrome Wuhan, China [DOI] 10.3390/pathogens10080936 PMC 바로가기 [Article Type] Review