New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatmentLianhuaqingwen에 대한 새로운 이야기 : IL6R/IL6/IL6ST 복합체는 COVID-19 치료의 잠재적 목표입니다.Research Paper Published on 2021-11-152022-08-31 Journal: Aging (Albany NY) [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] Activation addition Affect affecting AGE-RAGE signaling pathway alleviate Analysis approach Beta binding binding activity biological process clinical symptom Clinical symptoms complex COVID-19 cytokine Cytokines docking downstream enrichment analysis GeneCard hydrogen hydrogen bonds IL6 IL6R IL6R/IL6/IL6ST complex IL6ST IMPROVE Inflammatory response ingredient inhibit Interaction interleukin interleukin 6 LianhuaQingwen LianHuaQingWen (LHQW) lipopolysaccharide Luteolin mechanism molecular docking analysis N-terminal domain New Ontology pathogenic Pathways potential molecular Protein protein-protein interaction quercetin RAGE receptor regulate Regulation S protein screened severity of COVID-19 Signal transduction signaling pathway spike Spike protein subunit target TCMSP the S protein therapeutic target therapeutic targets treating COVID-19 Treatment UniProt wogonin [DOI] 10.18632/aging.203666 PMC 바로가기 [Article Type] Research Paper
The Molecular Mechanism of Multiple Organ Dysfunction and Targeted Intervention of COVID-19 Based on Time-Order Transcriptomic Analysis시간 순서 Transcriptomic 분석을 기반으로 한 다발성 장기 기능 장애의 분자 메커니즘 및 COVID-19의 표적 개입Immunology Published on 2021-08-242022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acetaminophen Activation addition Algorithm Angiogenesis B2M BFS algorithm Bioinformatics analysis biological process biological processe biological processes Brain caused CD40 CD40LG cell-mediated immune cell-mediated immune response changes in Comparative Compound Coronavirus disease 2019 COVID-19 CSF1 Curcumin CXCL10 cytokine Cytokine storm database defined determine Dexamethasone DNA downloaded drug energy metabolism enrichment analysis FCER1G FIVE gene co-expression network Gene Expression gene expression profile Gene expression profiles Gene ontology Genes heterogeneous high mortality hub genes ICAM1 identify immune gene immune response Immunity initial gene IRF7 LAT Lcn2 lead leukocyte lung metabolism molecular mechanism morphology Multiple multiple organ dysfunction multiple organ heterogeneity myeloid leukocyte neuronal Novel coronavirus olfactory organ organs other compound PageRank pandemic pattern PLAU predicted protein metabolism Protein–protein interaction Regulation Research response resveratrol RHOA rRNA second Spread SRC statins Stress stress response targeted intervention the cytokine storm TNFRSF1A TO-GCN Toxicogenomics Trachea tracheal Transmission Treatment unique was performed was used [DOI] 10.3389/fimmu.2021.729776 PMC 바로가기 [Article Type] Immunology
Weighted Gene Co-Expression Network Analysis Combined with Machine Learning Validation to Identify Key Modules and Hub Genes Associated with SARS-CoV-2 InfectionArticle Published on 2021-08-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] A549 acute respiratory syndrome Algorithm Analysis applied biological process Biomarkers Bronchial epithelium bronchial epithelium cells candidate drugs categories caused Cell cell line cells clinical trial co-expression network Combined conducted coronavirus correlated COVID-19 COVID-19 infection COVID-19 patient Defense disease drug drug target effective enrichment analysis evaluate Explainable artificial intelligence gene co-expression network gene signature HEPHL1 human lung epithelium IL-17 in vitro in vivo Infection KEGG pathway lung alveolar machine learning module network NHBE pandemic pathogenesis of COVID-19 pathogenicity pathway PGLYRP4 prognostic Regulation SARS-CoV-2 signaling pathway significantly therapeutic approaches therapeutic targets transcriptional change transcriptional profiling translational treat Treatment type I interferon Vaccine validation viral infection virus WGCNA [DOI] 10.3390/jcm10163567 PMC 바로가기 [Article Type] Article
Identification of COVID-19 and Dengue Host Factor Interaction Networks Based on Integrative Bioinformatics Analyses통합 생물정보학 분석을 기반으로 한 COVID-19 및 뎅기열 숙주 인자 상호작용 네트워크 식별Immunology Published on 2021-07-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] addition analysis Analysis bioinformatics bioinformatics analyses Biological functions biological process build candidate drug candidate drugs categories CCL2 CCL4 Clinical practice Co-infection conducted contribute coronavirus disease Coronavirus disease 2019 COVID-19 Dengue Dexamethasone drug dysregulated enrichment analysis expressed Factor Genes Genistein Health crisis Host host factor interaction networks ICAM-1 identification identify IL-1 Interaction international public health Intervention lung management mechanism molecular Molecular Complex Detection network outbreak pathologic pathway performed potential therapeutic agents potential therapeutic target potential therapeutic targets PPI probe protein-protein interaction provide raised receptor signaling respiratory Respiratory disease Result resveratrol screened signaling pathway signaling pathways significant effect significant pathways target therapeutic agents TNF-α Toll-like receptor Treatment upregulated gene upregulated genes [DOI] 10.3389/fimmu.2021.707287 PMC 바로가기 [Article Type] Immunology
Protective Effect of Zinc Oxide and Its Association with Neutrophil Degranulation in Piglets Infected with Porcine Epidemic Diarrhea VirusResearch Article Published on 2021-06-232022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] Coronavirus, [키워드] Administered administration affected analyses analysis anti-inflammatory effect Antiviral average biological process caused Colon Concentration Culture determine diarrhea differentially expressed gene dismutase dose drug Effect epidemic diarrhea Gene ontology growth histologic IL-1 β IL-6 IL-8 implication IMPROVE indicated Infection infectious dose Inflammation inhibit inoculated intestinal intestine lesions mechanism metabolism Microarray morphology neutrophil degranulation oxidative stress Oxide pathway PEDV peroxidase plasma Prevent Protein proteomic randomly divided redox status reduce reduction Replication rescued Result shown significantly increased small intestine TCID three group tissue treat Treatment villus Viral load virus were recorded Zinc zinc oxide [DOI] 10.1155/2021/3055810 PMC 바로가기 [Article Type] Research Article
The role of A-to-I RNA editing in infections by RNA viruses: Possible implications for SARS-CoV-2 infectionRNA 바이러스 감염에서 A-to-I RNA 편집의 역할: SARS-CoV-2 감염에 대한 가능한 의미Review Published on 2021-05-012022-09-11 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 변종, 치료법, [키워드] A-to-I RNA editing ADAR adenosine Affect APOBEC biological process cytosine cytosolic receptor cytosolic receptors Deamination double-stranded RNA double-stranded RNAs Effect enzyme events Evidence forms Future Host Host immune response implication Infection infections Innate innate immune response Innate immunity Inosine majority mapped Mutation mutations nucleotide patients with COVID-19 proliferation recent Recognition RNA RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection shown single nucleotide Spike protein Substitution the spike protein uracil viral infections Viral infections. Viral protein viral replication [DOI] 10.1016/j.clim.2021.108699 PMC 바로가기 [Article Type] Review
Hypothetical COVID-19 protection mechanism: hints from centenariansHypothesis Published on 2021-03-302022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] Adaptive immune response aging Antigen biological process centenarians complicate Coronavirus infection Course COVID-19 COVID-19 pandemic Diseases explain Fatality rate frailty Genetic greater Healthcare system help HLA HLA locus Hypothesis Infection involved leukocyte life threatening mechanism modulation Mortality Older Protective Region risk serious complication severe symptom severity of COVID-19 susceptibility [DOI] 10.1186/s12979-021-00226-z PMC 바로가기 [Article Type] Hypothesis
Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugsSARS-CoV-2에 대한 네트워크 분석 및 분자 매핑을 통해 약물 표적을 밝히고 임상적으로 개발된 약물의 용도 변경Article Published on 2021-03-012022-08-31 Journal: Virology [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] (hydroxychloroquine) Analysis Antibiotics antimalarial antiretroviral Azithromycin BCL-2 biological process carried chemokine Chemokine receptor clinically Combination coronavirus dietary supplement dietary supplements disease networks docking docking analysis docking study drug drug combination Drug repurposing drug target effective EGFR ErbB Estrogen event FoxO global pandemic GnRH HIF-1 host inflammatory response Hydroxychloroquine IL-17 insulin Interaction involved Jak-STAT KEGG pathway analysis life cycle Lopinavir LOPINAVIR AND RITONAVIR MAPK modulation molecular molecular docking molecular mechanism morbidity and mortality mortality rate multiple pathway multiple pathways network Neurotrophin novel Novel coronavirus Ontology PARP pathway platelet activation predict PRKCB Process analysis receptor reduce Ritonavir SARS-CoV-2 SARS–CoV–2. signaling pathway STAT suggested target targets thyroid hormone TNF Toll-like receptor Treatment VEGF Viral viral infection viral infectivity viral life cycle viral replication virus Vitamin Vitamin C [DOI] 10.1016/j.virol.2020.12.006 PMC 바로가기 [Article Type] Article
The analysis on the human protein domain targets and host-like interacting motifs for the MERS-CoV and SARS-CoV/CoV-2 infers the molecular mimicry of coronavirusResearch Article Published on 2021-02-172022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Analysis biological process biological processe carbon source coronavirus Coronavirus infection develop disease DMI domain effective enrichment expression help highly pathogenic host cells human protein humans information Interaction mapped mechanism Medicine MERS-CoV molecular MOST motif Ontology potassium channel Protein protein domain proteomes Regulation SARS-CoV SARS-CoV-2 T cell epitopes target Therapies Treatment Viral protein virus viruses was performed [DOI] 10.1371/journal.pone.0246901 PMC 바로가기 [Article Type] Research Article
Analysis of chicken macrophage functions and gene expressions following infectious bronchitis virus M41 infectionResearch Article Published on 2021-01-282022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] analyzed Apoptosis autophagy biological process bronchitis CCL4 CD36 Cell change CXCL12 expression expressions function Gene Expression Host host immune responses IBV IBV infection IBV-infected cells IFN-α IFN-γ IL-10 IL-1β IL-6 immune response Immunity Infection Infectious Bronchitis Virus Inflammation Interaction involved M41 Macrophage macrophage cell line Marco MDA5 MHCII MIF MOI morbidity and mortality multiplicity of infection pathogen pathogenic coronavirus Peripheral blood phagocytic Protein receptor Result significantly higher TLR3 TLR7 TNF-α viability virus virus replication were infected XCL1 [DOI] 10.1186/s13567-021-00896-z PMC 바로가기 [Article Type] Research Article