biosynthetic – Page 2 – Communicable Diseases Research

Heparan Sulfate Proteoglycans in Viral Infection and Treatment: A Special Focus on SARS-CoV-2

바이러스 감염 및 치료에서 헤파란 황산염 프로테오글리칸: SARS-CoV-2에 대한 특별 초점

Review

Published on 2021-06-182022-09-10
Journal: International Journal of Molecular Sciences
[Category] MERS, SARS, 변종, 진단,

Targeting Polyamines Inhibits Coronavirus Infection by Reducing Cellular Attachment and Entry

표적 폴리아민은 세포 부착 및 진입을 감소시켜 코로나바이러스 감염을 억제합니다

Article

Published on 2021-06-112022-09-11
Journal: ACS Infectious Diseases
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral antivirals attachment bat bats binding biosynthetic biosynthetic pathway cells China coronavirus coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus replication Coronaviruses COVID19 Critical Depletion disease drug target Endemic Epidemic evaluate facilitate human cells human populations humans in vitro infect Infection limitation MERS MERS-CoV metabolite Middle East Middle East respiratory syndrome Coronavirus outbreak Outbreaks pathway polyamine polyamines polyamines. reduce reduced replication mechanism respiratory syndrome coronavirus resulting SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Spread targeting treat widespread
[DOI] 10.1021/acsinfecdis.0c00491 PMC 바로가기 [Article Type] Article

Endophytes: the novel sources for plant terpenoid biosynthesis

Endophytes: 식물 테르페노이드 생합성을 위한 새로운 소스

Review

Published on 2021-06-012022-09-11
Journal: Applied Microbiology and Biotechnology
[Category] SARS, 유전자 메커니즘,

A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure

Article

Published on 2021-05-182022-10-04
Journal: Scientific Reports
[Category] 바이오마커,

[키워드] abnormality accumulating Acute respiratory failure Admission alteration analysis ANOVA applied ARF association bile acids Bioavailability Biochemistry Biomarkers biosynthetic change characterized cofactor Critically ill patient detect determine disorders dysfunction Efficiency Evidence FDR high accuracy hospital discharge include intensive care mechanical ventilation Medical research metabolism metabolite metabolome metabolomic mitochondrial morbidity and mortality Mortality NADP nicotinamide adenine dinucleotide non-survivor outcome pathway Patient phosphate predict predicted Prevalence Quantitative reduce mortality Respiratory failure Riboflavin semi-quantitative Sepsis serum severity Significant substrate survival survivor Survivors Systems biology target Treatment
[DOI] 10.1038/s41598-021-89716-0 PMC 바로가기 [Article Type] Article

Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients

전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다

Research Article

Published on 2021-04-012022-09-10
Journal: Mediators of Inflammation
[Category] MERS, SARS, 유전자 메커니즘,

[키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated
[DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article

Exploiting Connections for Viral Replication

Cell and Developmental Biology

Published on 2021-03-182022-10-31
Journal: Frontiers in Cell and Developmental Biology
[Category] COVID-19,

Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

Ipomoeassin-F는 SARS-CoV-2 스파이크 단백질과 숙주 세포막 수용체의 시험관 내 생합성을 억제합니다

125

Published on 2021-02-152022-09-10
Journal: Journal of Cell Science
[Category] MERS, 치료제,

[키워드] angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents assembly biogenesis biosynthetic block causative agent Cell-free translation component COVID-19 Endoplasmic reticulum envelope enzyme ER membrane ER membrane complex highlight highlighting Host host cell host cell membrane human cell in vitro inhibit inhibitor insertion mechanisms membrane protein Membrane proteins ORF8 protein ORF8 proteins paper pathogenic pathogenicity Pathogens Person plasma membrane Protein Protein target receptor reducing respiratory Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins Sec61 Sec61 translocon small molecule Spike protein structural proteins synthesised the SARS-CoV-2 therapeutic translocation Viral Viral particles viral pathogens Viral protein biogenesis viral spike viruses
[DOI] 10.1242/jcs.257758 PMC 바로가기 [Article Type] 125

Identification of 37 Heterogeneous Drug Candidates for Treatment of COVID-19 via a Rational Transcriptomics-Based Drug Repurposing Approach

Article

Published on 2021-01-252022-10-28
Journal: Pharmaceuticals
[Category] COVID-19,

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Metabolism

Published on 2021-01-132022-10-30
Journal: The Journal of Biological Chemistry
[Category] COVID-19, MERS, SARS,

[키워드] Activation activity ADP-ribose ADP-ribosylation antiviral activity antiviral responses biosynthetic boost cellular coronavirus Coronaviruses COVID-19 decrease demonstrated DNA damage ENhance enzyme expression expression of gene gene transcription host cell induce Infection Innate immunity interferon isozyme MHV murine hepatitis virus NAD biosynthesis NADP NAMPT nicotinamide nicotinamide adenine dinucleotide (NAD) nicotinamide riboside overexpression PARP PARP10 PARP12 PARP14 PARP7 Pathways pharmacological pharmacological intervention plus-stranded RNA virus poly(ADP-ribose) polymerase polymerase post-translational modification (PTM) Protein Replication RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 transcriptionally transcriptomics up-regulate
[DOI] 10.1074/jbc.RA120.015138 PMC 바로가기 [Article Type] Metabolism

SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host Cells

Molecular Biosciences

Published on 2021-01-112022-10-31
Journal: Frontiers in Molecular Biosciences
[Category] COVID-19,

[키워드] absence acute respiratory syndrome anabolic approaches biochemical biosynthetic cellular Clinical data complex coronavirus coronavirus disease COVID-19 demonstrated develop dysregulated effort Escalation event Evidence Factor Glucose Glutamine glutaminolysis HIF-1α host cell Hypothesis hypoxia-inducible factor 1-alpha hypoxia-inducible factor-1 alpha in vitro in vivo infect Infection mammalian metabolic metabolic reprogramming metabolism mTORC1 pandemic Pathogenesis Perspective promote PSAT1 Rapamycin Research researcher SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 pathogenesis Support therapeutic transcription factor Treatment viral infection viral infections
[DOI] 10.3389/fmolb.2020.627842 PMC 바로가기 [Article Type] Molecular Biosciences