Complement blockade with eculizumab for treatment of severe Coronavirus Disease 2019 in pregnancy: A case series임신 중 중증 코로나바이러스 질환 2019 치료를 위해 에쿨리주맙으로 봉쇄 보완: 사례 시리즈Clinical Trial Published on 2022-08-012022-09-12 Journal: American journal of reproductive immunology (New Y [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] Administered Adults adverse outcomes All participant bilateral pulmonary infiltrate blockade case sery center complement complement system proteins COVID-19 Day demonstrated dose eculizumab eligible enrolled evaluated event Expanded Access Program hospital discharge Hospital stay indicated individuals inhibitor mechanical ventilation median multicenter nasal Neonatal non-rebreather mask open label outcome Oxygen requirement participant Patient pharmacokinetic Pregnancy pregnant Primary outcome Protein ranged secondary severe COVID-19 still hospitalized survival the median treat Treatment [DOI] 10.1111/aji.13559 PMC 바로가기 [Article Type] Clinical Trial
Plasmatic renin-angiotensin system in normotensive and hypertensive patients hospitalized with COVID-19Research article Published on 2022-08-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 바이오마커, 치료기술, [키워드] ACE ACE2 ACE2 expression ACE2 protein acute respiratory syndrome Analysis Ang II angiotensin Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitors blockade cause circulating control group coronavirus COVID-19 COVID-19 group COVID-19 patient COVID-19 patients enzymatic activity etiological agent healthy healthy subjects Hospitalized hypertension hypertensive hypertensive patient investigated medications normotensive not different Patient patients protein level RAS receptor remained renin-angiotensin system reported Result significantly Support treated Treatment were excluded were measured with COVID-19 [DOI] 10.1016/j.biopha.2022.113201 [Article Type] Research article
Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial Research Published on 2022-08-012022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, [키워드] antibodies approved biopsy blockade Blood BRAF carried circulating clinical trial Colorectal cancer disease DNA Efficacy EGFR eight Endpoint enrolled EudraCT growth factor monoclonal antibody mutant alleles Mutation Open-label Patient patients primary endpoint randomized trial RAS receptor regimen responses restrict secondary single-arm phase 2 Standard-of-care subsequent survival therapy Tolerability Treatment Trial Tumor were excluded wild-type Withdrawal [DOI] 10.1038/s41591-022-01886-0 [Article Type] Research
PD-1 blockade unblocks immune responses to vaccination News & Views Published on 2022-07-282022-10-05 Journal: Nature Immunology [Category] 바이오마커, [키워드] blockade immune response vaccination [DOI] 10.1038/s41590-022-01254-7 [Article Type] News & Views
Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance Research Published on 2022-07-232022-10-05 Journal: Communications Biology [Category] 변종, [키워드] analyses applied blockade blocker blockers docking Effect endolysosomal endomembrane facilitate histidine Human IC50 identify inhibit inhibitor inhibitors interact Kinase inhibitor kinase inhibitors mechanism molecular mutant pharmacological PI3K PIKfyve inhibitor residue sensitivity Substitution [DOI] 10.1038/s42003-022-03701-5 [Article Type] Research
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19멜라토닌: COVID-19의 급성 후유증에서 바이러스 상 분리 및 Epitranscriptomics의 조절Review Published on 2022-07-232022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료법, [키워드] Activation acute infection alteration antiviral immune response blockade change changes Concentration COVID-19 DDX3X depolarization derepression distress early infection ENhance envelope protein Epigenetic Evolution G3BP1 Genome genomic Glycolysis GSK-3 herd immunity Host host cell host genome human host immune immune responses Immunity induce Infection influence LINE1 liquid-liquid phase separation m6A maintain manifestation mechanisms melatonin membrane microenvironment mitochondrial modifications morphology nuclear nucleocapsid outcome oxidative oxidative stress PASC phase Prevent pro-inflammatory cytokine promote PROTECT regulate resulting RNA SARS-CoV-2 virus separation sequestration Signaling signaling cascades significantly Stress stress granule stress granules Support suppress switching the SARS-CoV-2 the SARS-CoV-2 virus Transcription transcriptomic viral genome viral persistence viral replication Viral RNA virus [DOI] 10.3390/ijms23158122 PMC 바로가기 [Article Type] Review
Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 TherapyCOVID-19 치료에 사용되는 항체에 의한 중화로부터 보호할 수 있는 ACE2 독립적 진입 경로에 대한 증거Article Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] ACE2 ACE2 binding analyzed antibody Antibody-mediated neutralization blockade Can cell entry cell line cellular receptor COVID-19 COVID-19 patient COVID-19 therapy E484K Evidence hepatoma host cells Huh-7 Imdevimab Infection Interaction lung cell mechanism Mutation NCI-H1299 neutralization Neutralizing antibodies neutralizing antibody position PROTECT Protein rescued SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants spike Spike protein the SARS-CoV-2 therapy vaccination variants of concern Vero Cell Viral viral entry virus VoC [DOI] 10.1128/mbio.00364-22 PMC 바로가기 [Article Type] Article
RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIaRANBP2 및 USP9x는 아데노바이러스 마이너 코트 단백질 IIIa의 핵 수입을 조절합니다Article Published on 2022-06-162022-09-11 Journal: PLoS Pathogens [Category] 유전자 메커니즘, [키워드] accumulation acute respiratory illness acute respiratory illnesses Adenovirus Affinity purification Amino acid amino acids Analysis antiviral therapeutics antiviral therapy bind binding blockade C-terminus Cell cell nuclei cells cellular competition conjunctivitis counteract COVID-19 demonstrated deregulated disparate expression Host implication indicated infected cells Infection interact Interaction interactions mass spectrometry maturation mechanism Microscopy nuclear nuclei nucleus outbreak parasites protease Protein Proteins Ranbp2 reduced regulate respiratory pathogen retention subsequent surface plasmon surface plasmon resonance transmission electron microscopy Transport USP9x Vaccine viral genome replication Viral particles Viral protein virion virion assembly virus virus-infected cell virus-infected cells wild type [DOI] 10.1371/journal.ppat.1010588 PMC 바로가기 [Article Type] Article
An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse ModelADAM17 중화 항체는 COVID-19 마우스 모델에서 바이러스 부담을 증가시키면서 염증과 사망률을 감소시킵니다Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 ADAM17 ADAM19 adverse outcome Alter angiotensin anti-viral role antibody appear blockade blocked burden Cell cell entry receptor cellular activation cleave COVID-19 COVID-19 pathogenesis COVID-19 patients Critical ectodomain Increasing Inflammation Inflammatory inflammatory cascade K18-hACE2 less lung Lung pathology lung; metalloproteinase mice Model monoclonal antibody mouse mouse model pathway Proinflammatory cytokine promote protease Proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 viruses significantly increased significantly lower therapeutic TNF-α Transgenic mouse transmembrane viral burden virus while [DOI] 10.3389/fimmu.2022.918881 PMC 바로가기 [Article Type] Article
Antibody and T cell responses to COVID-19 vaccination in patients receiving anticancer therapies항암치료를 받는 환자의 코로나19 백신접종에 대한 항체 및 T세포 반응Article Published on 2022-06-012022-09-11 Journal: Journal for immunotherapy of cancer [Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료제, [키워드] active treatment adrenal crisis Adrenal insufficiency Affect Anti-CD20 antibodies Anti-CD20 antibody Anti-viral antibodies antibody antibody formation Antibody titer Antibody titers Anticancer therapy B cells B-cell B.1.617.2 blockade Cancer CD4 CD8 Cell cellular Chemoimmunotherapy Chemotherapy Corticosteroids COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccinations COVID-19 vaccine trials cross-reactive cytokine detectable develop dose doses effector cells Endocrine expressed follicular generate healthy donor healthy donors helper cells Humoral response hypoadrenalism Hypothesis IgG antibody titer immune Immunocompromised immunogenic immunogenicity immunogenicity, vaccine Immunotherapy intracellular cytokine staining Lymphocytes mRNA vaccine Multiple myeloma Myeloma n=36 no differences oncology patients Participants Patient Patients with cancer PD-1 peptide peptides Phase 3 profile Prophylactic RBD reactivity receiving Receptor binding domain Safe seronegative seronegative patient Side effect solid tumors spike Spike protein steroid Steroids Stress symptomatic T cell T cell response T cell responses T cells T follicular helper cells T-lymphocytes targeted therapy the SARS-CoV-2 therapy Treatment treatment groups tumors Two patient two patients vaccination Vaccinations Vaccine variant spike was measured were assessed were excluded wild-type WT spike [DOI] 10.1136/jitc-2022-004766 PMC 바로가기 [Article Type] Article