Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamstersSARS-CoV-2와 인플루엔자 바이러스의 동시 감염은 햄스터에서 더 심각하고 장기적인 폐렴을 유발합니다Article Published on 2021-10-282022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjacent area body weight Body weight loss cause caused Cell cell tropism Co-infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms fatality growth hamster hamsters Health IAV IL-6 immunohistochemical analyses in vivo Infection Infectious diseases Influenza influenza A influenza A virus Influenza virus inhibit Interference involved lung Lungs organ organs pathogen Pathogens Pneumonia Post-infection public health respiratory risk SARS-CoV-2 SARS-CoV-2-infected hamsters sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 significant increase Spread Symptom Virology virus virus viruses weight loss [DOI] 10.1038/s41598-021-00809-2 PMC 바로가기 [Article Type] Article
Prevention of Cyclophosphamide-Induced Immunosuppression in Mice With Traditional Chinese Medicine Xuanfei Baidu DecoctionPharmacology Published on 2021-10-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] administration applied Baidu Body weight loss calculated CD4 CD8 cell proliferation China Chinese COVID-19 disease Cyclophosphamide cytokine Decoction ELISA evaluate evaluated groups IFN-γ IgG IgM IL-2 IL-4 IL-6 expression immune immune modification Immunoglobulin Immunosuppression liver LPS lymphocyte mechanism Medicine mice Modification organ prevention proliferation protective effect reduction RT-PCR serum significantly spleen Splenic staining Structure suggested suppressed T lymphocyte therapy TNF-α Traditional Traditional Chinese medicine Treatment was measured was performed Xuanfei Baidu Decoction [DOI] 10.3389/fphar.2021.730567 PMC 바로가기 [Article Type] Pharmacology
Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19Pharmacology Published on 2021-10-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis Anu AYUSH board Body weight loss characterized coronavirus coronavirus disease COVID-19 cytokine Effect exhibited expression Formulation Genes hamster Herbal histopathological indicated Infection inhibiting initiate intranasal lung Lung pathology Model molecular analysis mRNA expression Oil plant pro-inflammatory cytokine Prophylactic provided Pulmonary pathology reduced reduction in Respiratory failure SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection severity Th1 Th17 upper respiratory tract viral entry Viral load virus [DOI] 10.3389/fphar.2021.746729 PMC 바로가기 [Article Type] Pharmacology
Highly susceptible SARS-CoV-2 model in CAG promoter–driven hACE2-transgenic miceCAG 프로모터 구동 hACE2 형질전환 마우스에서 매우 민감한 SARS-CoV-2 모델Resource and Technical Advance Published on 2021-10-082022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] acute lung injury angiotensin Angiotensin-converting enzyme animal model animal models body weight Body weight loss CAG caused chemokine Consequences COVID-19 cytokine death develop early stage elevated enzyme Genome hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 immunization immunized mice infected with SARS-CoV-2 Infection infection with SARS-CoV-2 injection lethality Lung injury Medicines mice Mouse models pathogenicity plasma prevented SARS-CoV-2 SARS-COV-2 infection severe symptom Spread subsequent susceptibility susceptible tandem therapeutic Therapeutics Vaccine Viral antigen weight loss [DOI] 10.1172/jci.insight.152529 PMC 바로가기 [Article Type] Resource and Technical Advance
SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective ImmunityS1/S2 절단 부위에서 돌연변이를 갖는 SARS-CoV-2는 약화된 독성을 나타내고 보호 면역을 부여합니다Research Article Published on 2021-08-242022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] activate affecting airway animal model attenuation B.1.1.7 Bearing body weight Body weight loss cause cell tropism cellular entry cleavage cross-react exhibited furin furin cleavage site furin protease growth hamster hamsters Host immunogens infected with SARS-CoV-2 Infection Inflammatory response inoculated investigated Lineage lineages Mild motif mutant mutants Mutation Neutralizing antibodies P.1 parental Pathogenesis pathogenic pathway polybasic potential benefit potential benefits protective neutralizing antibodies protective neutralizing antibody proteolytic cleavage respiratory S gene S1/S2 SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 Site spike Spike protein subsequent the spike protein tissue variant Viral viral growth weight loss [DOI] 10.1128/mBio.01415-21 PMC 바로가기 [Article Type] Research Article
Endothelial cell infection and dysfunction, immune activation in severe COVID-19내피 세포 감염 및 기능 장애, 심한 Covid-19에서의 면역 활성화Research Paper Published on 2021-07-062022-09-10 Journal: Theranostics [Category] MERS, SARS, 진단, 치료기술, [키워드] Activation adhesion alveolar septa animals body weight Body weight loss Brain infection cadherin cause Cell circulation Coagulation collected complement conducted contribute correlated COVID-19 COVID-19 disease COVID-19 patients cytokine Deceased develop downregulation dysfunction edema electron microscopy endothelial Endothelial cell endothelial cells Endotheliitis Eosinopenia epithelial cells evidenced fatality hemorrhage ICAM1 immune activation Immune cell immune cells immunostaining infect Infection initial Injury interstitial inflammation K18 K18-hACE2 lung Lung epithelial cells Lungs lymphocytopenia mice Microscopy NHP NHP models organ organs Pathogenesis pathway Pathways Patient perivascular inflammation Platelet Platelets Pneumonia pulmonary PULMONARY VESSELS rationale Result RNA-seq analyses SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 severe COVID-19 disease severity Signaling Single Cell up-regulation upregulated Vascular VCAM1 VE-cadherin vessel weight loss while [DOI] 10.7150/thno.61810 PMC 바로가기 [Article Type] Research Paper
Predictive Value of Precision-Cut Lung Slices for the Susceptibility of Three Animal Species for SARS-CoV-2 and Validation in a Refined Hamster ModelArticle Published on 2021-06-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] activity acute respiratory syndrome addition administration analysis animal animal model animal models Body weight loss can be used Cell culture coronavirus dose evaluated Evidence experiment facilitate group hamster Hamster model hamsters Health histological change histology scores in silico in vitro Inclusion incubated infection with SARS-CoV-2 inoculated intranasal route investigated lung Lung pathology Lungs Model oropharyngeal swab parameter pathology pig precision-cut lung slices quantification Receptor binding reducing replicated Replication Research respiratory tissue robust SARS-CoV-2 SARS-CoV-2 strains scoring system semi-quantitative sensitivity slice Specy susceptibility susceptibility to infection validation value Viral load virus replication viruses was obtained [DOI] 10.3390/pathogens10070824 PMC 바로가기 [Article Type] Article
Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2폐 질환이 유발된 쥐는 SARS-CoV-2에 노출된 후 심각한 폐 염증과 사망률을 보입니다.Research Article Published on 2021-06-222022-09-10 Journal: JCI Insight [Category] MERS, 유전자 메커니즘, 진단, [키워드] ACE2 acute lung injury angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 binding Bleomycin body weight Body weight loss canonical caused contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deleterious effect deleterious effects Exacerbation greater heart Infection low dose low-dose lung Lung injury Lungs manifested mechanism mice Mild monoclonal antibodies monoclonal antibody morbidities morbidity Mortality mortality rate mortality rates Mouse models murine passive transfer Pathologies pathology Patient polyclonal RBD receptor Receptor binding domain Replication ricin SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-COV-2 infection serum severe disease severe lung inflammation subgenomic mRNA susceptible sustained the SARS-CoV-2 tissue transfer unique Viral viral cell viral entry viral infection viral RBD Viral RNA virus virus particle virus particles weight loss [DOI] 10.1172/jci.insight.145916 PMC 바로가기 [Article Type] Research Article
A novel linker-immunodominant site (LIS) vaccine targeting the SARS-CoV-2 spike protein protects against severe COVID-19 in Syrian hamstersResearch Article Published on 2021-05-092022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] Administered Body weight loss change composed COVID-19 effective Efficacy expected hamster histopathological Immunity immunodominant in vivo less linear linker-immunodominant site lung viral load natural infection Neutralizing antibody response pandemic Pneumonia PROTECT Protective SARS-CoV-2 severe COVID-19 significantly Spike protein subcutaneous injection tested the RBD the SARS-CoV-2 unlikely vaccination Vaccine vaccine candidate [DOI] 10.1080/22221751.2021.1921621 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection of Chinese hamsters (Cricetulus griseus) reproduces COVID-19 pneumonia in a well-established small animal model중국 햄스터(Cricetulus griseus)의 SARS-CoV-2 감염은 잘 정립된 작은 동물 모델에서 COVID-19 폐렴을 재현합니다Article Published on 2021-05-012022-09-12 Journal: Transboundary and emerging diseases [Category] SARS, 진단, [키워드] accompanied animal model applied Body weight loss bronchitis caused Chinese hamster Clinical symptoms coronavirus COVID-19 Cricetulus demonstrated experimental animal models feature Genome griseus Histopathology histopathology. Infection Lower respiratory tract medical intervention molecular pandemic Pathogenesis Pneumonia pre-clinical testing Research robust SARS-COV-2 infection SARS-CoV-2 pandemic susceptible the disease Therapies therapy Transcriptome vaccination Vaccine virus replication [DOI] 10.1111/tbed.13837 PMC 바로가기 [Article Type] Article