breath – Page 2 – Communicable Diseases Research

Evaluation of canine detection of COVID-19 infected individuals under controlled settings

Article

Published on 2022-09-012022-11-15
Journal: Transboundary and emerging diseases
[Category] COVID19(2023년), SARS, 치료기술,

Collection and detection of SARS-CoV-2 in exhaled breath using face mask

안면 마스크를 사용하여 호기에서 SARS-CoV-2 수집 및 감지

Article

Published on 2022-08-182022-09-11
Journal: PLoS ONE
[Category] SARS, 치료기술, 치료제,

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

ACE2 결합은 코로나바이러스 항체를 광범위하게 중화시키는 SARS-CoV-2 융합 펩타이드를 노출시킵니다

Article

Published on 2022-08-122022-09-11
Journal: Science (New York, N.y.)
[Category] COVID19(2023년), MERS, SARS, 비임상, 진단,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Alpha alpha- analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal coronavirus Animal coronaviruses antibody approach betacoronaviruses binding breadth breath conserved coronavirus coronavirus spike protein donors enzyme epitope functional fusion peptide hidden host receptor Host receptors immune in vitro in vivo mAb mAbs monoclonal antibodies monoclonal antibody motif neutralize Neutralizing Neutralizing activity omicron pathology peptide prefusion recognize reduce respiratory SARS-CoV-2 selected Seven severe acute respiratory syndrome Coronavirus somatic mutations spike glycoprotein Spike proteins the SARS-CoV-2 Viral viral burden virus viruses
[DOI] 10.1126/science.abq2679 PMC 바로가기 [Article Type] Article

rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbits

rVSV-ΔG-SARS-CoV-2-S 백신: NZW 토끼에서 반복되는 근육내(IM) 독성, 국소 내성, 면역원성 및 생체 분포 연구

Article

Published on 2022-08-012022-09-11
Journal: Archives of Toxicology
[Category] COVID19(2023년), MERS, SARS, 비임상, 진단, 치료기술,

[키워드] Administered animals antibody antibody levels Antibody titers Antigen assigned binding biodistribution biodistribution study body temperature body weight breath C-reactive protein change Clinical pathology Clinical signs clinical trial clinical trials correlated COVID-19 detection elicited evaluate Express followed by Gross High-dose high-dose group histopathological iliac lymph node immunogenicity inflammatory reaction injection intervals intramuscular intramuscularly Local local reactions Lymph node mesenteric lymph nodes Necrosis Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers New Nonclinical ophthalmology pathology Phase 2 platform Reactions repeated RNA Safe Safety SARS-CoV-2 SARS-CoV-2-S significant increase spleen stomatitis supported systemic the vaccine Tolerance Toxicity two group two groups Urinalysis vaccination Vaccine vaccine doses vaccine. Vector-based vaccine vesicular stomatitis vesicular stomatitis virus Viremia VSV was performed
[DOI] 10.1007/s00204-022-03302-5 PMC 바로가기 [Article Type] Article

Fast and noninvasive electronic nose for sniffing out COVID-19 based on exhaled breath-print recognition

Research

Published on 2022-08-012022-10-05
Journal: NPJ Digital Medicine
[Category] 바이오마커, 변종, 임상, 진단, 치료기술, 치료법,

Clinical characteristics analysis of COVID-19 patients from the first significant community outbreak by SARS-CoV-2 variant B.1.1.7 in Taiwan as experienced from a single northern medical center

Research article

Published on 2022-08-012022-10-05
Journal: Journal of microbiology, immunology, and infection
[Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] 28-day mortality acute respiratory syndrome age Analysis B.1.1.529 B.1.1.7 B.1.1.7 lineage Bacteria breath Characteristics characteristics of patient characterized clinical Community Comorbidity Complication condition coronavirus coronavirus disease cough COVID-19 COVID-19 patient Critical disease Fever fungi implementation increased mortality indicated infected with SARS-CoV-2 Infection initial Inpatient less Lineage Mortality multiple comorbidities old age Older outbreak Patient Population positive presenting symptom presenting symptoms Result SARS-CoV-2 SARS-CoV-2 B.1.1.7 SARS-CoV-2 variant severe disease specimen Taiwan vaccination variant virus
[DOI] 10.1016/j.jmii.2022.08.007 [Article Type] Research article

Capnodynamic monitoring of lung volume and blood flow in response to increased positive end-expiratory pressure in moderate to severe COVID-19 pneumonia: an observational study

Observational Study

Published on 2022-07-312022-10-05
Journal: Critical Care
[Category] 임상,

[키워드] ANOVA arterial oxygen tension baseline blood flow breath changes in Confidence intervals correlated correlation correlation coefficient COVID-19 dead decrease Decreased demonstrated effective End-Expiratory Pressure facilitate feasibility fraction group increase in instantaneous less lung Lung perfusion Lung volume mean difference Mechanical mechanical ventilation mechanically ventilated patient moderate monitoring negative correlation non-responder non-responders outcome oxygen Oxygenation P/F P/F ratio Patient Pearson PEEP physiological physiological response Pneumonia Positive end-expiratory pressure positive end-expiratory pressure. positively correlated Primary outcome pulmonary blood flow recruited reported Respiratory failure Responder responders response secondary severe COVID-19 severe respiratory failure statistically to define Ventilation Volume was increased
[DOI] 10.1186/s13054-022-04110-0 PMC 바로가기 [Article Type] Observational Study

Vaccination with Omicron Inactivated Vaccine in Pre-vaccinated Mice Protects against SARS-CoV-2 Prototype and Omicron Variants

사전 백신 접종된 마우스에서 오미크론 비활성화 백신을 사용한 백신 접종은 SARS-CoV-2 프로토타입 및 오미크론 변이체로부터 보호합니다

Article

Published on 2022-07-192022-09-11
Journal: Vaccines (Basel)
[Category] 비임상,

Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer

COVID-19 질병에 대한 에어로졸 중재 개발: 분무기를 통해 투여되는 가용성 ACE2(APN01)의 내약성

Article

Published on 2022-07-112022-09-11
Journal: PLoS ONE
[Category] COVID19(2023년), SARS, 비임상, 임상,

[키워드] ACE2 Administered administration aerosol aerosolization airways Ang II angiotensin binding binding activity breath catalytic caused cleavage clinical trial Concentration conducted COVID-19 Critical deregulated development Efficacy enzymatic activity evaluated Evidence evidence of feasible healthy volunteer healthy volunteers in vitro individual Infection initiated Intervention Kinin limit lung lung damage mitigate mouse model neutralization neutralize notable Pathways phase preliminary evidence RAS RAS activity recombinant ACE2 Renin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signaling soluble ACE2 Spread subsequent Tolerability toxicities virus
[DOI] 10.1371/journal.pone.0271066 PMC 바로가기 [Article Type] Article

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases

조직간 단세포 기질 아틀라스는 4가지 만성 염증성 질환에서 공유된 병리학적 섬유아세포 표현형을 식별합니다.

Article

Published on 2022-07-082022-09-11
Journal: Med (New York, N.Y.)
[Category] 비임상,

[키워드] Activation affected animal model animal models Arthritis atlas atopic dermatitis breath CCL19 chronic inflammatory disease chronic inflammatory diseases Clusters COL3A1 Critical CXCL10 disease Diseases donors exacerbated fibroblast fibroblasts Foundational research heterogeneity Hoffmann-La Roche identify immune individual inflamed tissue Inflammation Inflammatory bowel disease Inflammatory diseases integration interstitial Interstitial lung disease intestinal inflammation intestine joint lack lung Lung disease Lungs mapped organ systems Pathogenesis pathogenic pathway Pathways phenotype Phenotypes pro-inflammatory reveal rheumatoid arthritis Roche salivary gland salivary glands scRNA-seq single-cell Single-cell RNA sequencing Sjögren's syndrome SPARC stromal syndrome synovium therapeutic target ulcerative colitis ulcerative colitis.
[DOI] 10.1016/j.medj.2022.05.002 PMC 바로가기 [Article Type] Article