Calu – Page 2 – Communicable Diseases Research

B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination

B.1.617.2는 증가된 효율성으로 폐 세포에 들어가 융합하고 감염 및 백신 접종에 의해 유도된 항체를 회피합니다.

Article

Published on 2021-10-122022-09-11
Journal: Cell Reports [Category] MERS, SARS, 변종, 진단,

A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

새로운 종류의 TMPRSS2 억제제는 SARS-CoV-2 및 MERS-CoV 바이러스 진입을 강력하게 차단하고 인간 상피 폐 세포를 보호합니다

410

Published on 2021-10-112022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 신약개발,

[키워드] activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antiviral antiviral drug block broad-spectrum antivirals Calu Calu-3 calu-3 cells camostat can be used cell entry chimeric clinical development coronavirus COVID-19 COVID-19 treatment Cytopathic effect cytopathic effects drug drug candidate drug design Drug discovery drugs Efficacy epithelial epithelial cell epithelial cells full-length half-life half-maximal effective concentration half-maximal inhibitory concentration help host cell human lung in vivo Influenza influenza viruses inhibiting inhibitor lead lung lung cell lung tissue mechanism MERS-CoV mice Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus nafamostat other coronavirus other coronaviruses Pathogenesis pharmacokinetics plasma probe protease Protease inhibitor PROTECT Protein PS-SCL respiratory respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 virus selective Serine serine protease TMPRSS2 severe acute respiratory syndrome Coronavirus Significance significantly specificity Spike protein stability structure-based drug discovery the Spike therapeutic target TMPRSS2 TMPRSS2 inhibitor TMPRSS2 inhibitors TMPRSS2 protein treat Treatment Viral viral entry viral pathogenesis Viral protein viral spread virus
[DOI] 10.1073/pnas.2108728118 PMC 바로가기 [Article Type] 410

Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agents

Ephedra Sinica STAPF의 활성 성분은 ACE2와 SARS-COV-2 RBD 사이의 상호 작용을 방해합니다 : 강력한 COVID-19 치료제

Article

Published on 2021-10-052022-08-31
Journal: Journal of ethnopharmacology [Category] MERS, SARS, 치료제,

[키워드] 293T-ACE2 4-hydroxy-6-methoxyquinoline-2-carboxylic acid (PubChem CID: 22017520) 4-hydroxyquinoline-2-carboxylic acid (PubChem CID: 3845) 4,6-dihydroxyquinoline-2-carboxylic acid (PubChem CID: 440752) ACE2 ACE2-RBD activity alleviate angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Asia Asthma binding domain Calu calu-3 cells carboxylic acid carried cells Chinese Cold component Compound compounds cough COVID-19 COVID-19 therapeutic agent Deterioration disrupt disrupting docking domain effort ephedra Ephedra sinica Ethanol HPLC hydrogen Hydrogen bond hydroxy indicated inhibit inhibit SARS-CoV-2 inhibiting Inhibition assays inhibitory activity Interaction Isolation knock-out Lung diseases material mechanism molecular docking NMR observé potent potential therapeutic agent potential therapeutic agents PPI PPI inhibitor Prevent protein-protein interaction provided pseudoviruses PubChem quinoline Quinoline-2-carboxylic acid S protein SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 virus SARS-CoV-2 virus infection Spike protein SPR Structure structures suggested surface plasmon surface plasmon resonance Symptom TCM the SARS-CoV-2 therapeutic agents these compound these compounds Traditional Chinese medicine treat viropexis virus infection were used
[DOI] 10.1016/j.jep.2021.114303 PMC 바로가기 [Article Type] Article

Preliminary Evidence for IL-10-Induced ACE2 mRNA Expression in Lung-Derived and Endothelial Cells: Implications for SARS-Cov-2 ARDS Pathogenesis

폐 유래 세포 및 내피 세포에서 IL-10 유도 ACE2 mRNA 발현에 대한 예비 증거: SARS-Cov-2 ARDS 발병에 대한 의미

Immunology

Published on 2021-09-272022-09-11
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단,

[키워드] “cytokine storm” ACE2 ACE2 expression ACE2 mRNA acute respiratory distress acute respiratory distress syndrome alarmin angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-inflammatory agent anti-inflammatory cytokine ARDS biguanide binding Calu Calu-3 Calu-3 cell line Cell cell type cell types cells clinic clinically COVID-19 pathogenesis COVID-19 pro-inflammatory cytokines cytokine Cytokine storm Cytokines Disseminated intravascular coagulation elevated Endothelial cell endothelial cells enzyme Evidence evidence of expressed Host IL-10 IL-1β IL-6 in vitro increase in Infection Inflammation intestinal intravascular coagulation investigated losartan lung mechanism metformin modulation Non-pulmonary observation olmesartan organism Other patients preliminary evidence pro-inflammatory cytokines PROTECT provided question receptor Regulation renal required respiratory distress SARS-CoV-2 sartans Spike protein spike protein of SARS-CoV-2 syndrome the spike protein Thromboembolism Treatment upregulate upregulation Vasculitis Viral worse prognosis
[DOI] 10.3389/fimmu.2021.718136 PMC 바로가기 [Article Type] Immunology

A Potential Role of the CD47/SIRPalpha Axis in COVID-19 Pathogenesis

Covid-19 병인에서 CD47/Sirpalpha 축의 잠재적 역할

Article

Published on 2021-09-222022-08-31
Journal: Curr Issues Mol Biol [Category] SARS, 바이오마커, 유전자 메커니즘, 진단,

[키워드] Acute kidney injury addressed Air-liquid interface antibody Antiviral antiviral therapy Asymptomatic axis binding bronchial epithelial cells Caco-2 Caco-2 cells Calu calu-3 cells Cancer caused CD47 condition contribute contributing to coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic COVID-19 pathology COVID-19 research COVID-19-related complication COVID-19-related complications Culture develop diabete diabetes disease elevated epithelial cells expression Factor fibrosis fraction group hyperinflammation hypertension IAP Immune escape immune response increase indicated individual infected cells infected individual infected individuals life-threatening Lung fibrosis mechanism Mild Monocytes MOST myocardial injury Older age Potential primary human bronchial epithelial cells primary human monocytes pulmonary hypertension Research resulting risk factor role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2-infected individual SARS-CoV-2-infected individuals severe COVID-19 severe disease SIRPalpha Small molecules stroke therapeutic target vascular disease vasoconstriction virus-infected cells
[DOI] 10.3390/cimb43030086 PMC 바로가기 [Article Type] Article

Paradoxical effects of cigarette smoke and COPD on SARS-CoV-2 infection and disease

SARS-COV-2 감염 및 질병에 대한 담배 연기 및 COPD의 역설적 영향

Research

Published on 2021-08-232022-09-10
Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, SARS, 치료법,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect airway airways alveolar alveolar epithelial cell bronchial epithelial cell C57BL/6 Calu Calu-3 cell calu-3 cells chronic obstructive chronic obstructive pulmonary disease cigarette smoke Control controls COPD coronavirus coronavirus 2 determined by disease double-stranded RNA dsRNA Effect ELISA entry receptor epithelia epithelial cells evaluated expression of SARS-CoV-2 HBECs human bronchial epithelial cells immunofluorescence immunofluorescence staining immunostaining in vitro In vitro infection in vivo independent Infection inhibited investigated mice mRNA level mRNA levels N protein obstructive pulmonary disease Patient Plaque assay pulmonary disease qPCR receptor ACE2 replicative respiratory Result RT-qPCR SARS-CoV-2 entry receptor SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity staining supplementary material TMPRSS2 Treatment Viral viral replication western blot
[DOI] 10.1186/s12890-021-01639-8 PMC 바로가기 [Article Type] Research

SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells

SARS-CoV-2 분리주는 인간 면역 세포에서 손상된 복제를 보여주지만 폐 상피 세포에서 복제하고 타고난 면역을 유도하는 차등 능력을 보여줍니다

Research Article

Published on 2021-08-112022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] Ability acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Calu Calu-3 cell calu-3 cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines dendritic cells epithelial epithelial cells Finnish Gene Expression HCoV Human human cell human cells human DC human lung human macrophage IFN IFNs Immune cell immune cells Impaired induce infect Infection Inflammatory response Inflammatory responses information Innate Innate immunity interferon interferon (IFN) response interferon response interferons interferons (IFNs interferons (IFNs) isolate isolates knowledge lung epithelial cell Lung epithelial cells Lymphocytes macrophages mechanism Monocytes open organ pandemic Pathogenesis pathogenesis of SARS-CoV-2 regulate Regulation replicate replicated Replication respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus show Spread target organ TPCK-treated trypsin type I Type III IFN Vero E6 cell viral replication
[DOI] 10.1128/Spectrum.00774-21 PMC 바로가기 [Article Type] Research Article

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies

SARS-COV-2 감염 연구에 적합한 모델로서 세포주 CL-14, CL-40 및 CAL-51의 확인

Research Article

Published on 2021-08-022022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 mRNA Apoptosis approach Aside biochemical Breast cancer Caco-2 Calu Calu-3 cancer cell line Cell Cell culture cell culture experiment cell culture experiments cell line cell lines cellular cellular entry Colon cancer correlation defined Drug screening entry receptor expression Factor host susceptibility Human Human cancer cell lines human cell lines identification identify Immunity In vitro infection Infection intrinsic LINE missense variant overexpression permissiveness receptor Research resources RNA-seq data SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Scientific community screened the SARS-CoV-2 TMPRSS2 Viral viral entry viral infection virus
[DOI] 10.1371/journal.pone.0255622 PMC 바로가기 [Article Type] Research Article

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

전임상 평가를 통해 SARS-CoV-2 및 이의 변이체에 대한 범-CoV 융합 억제제에 대한 구조 및 기능 기반

Article

Published on 2021-07-292022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 신약개발, 치료제,

[키워드] (alpha administration African Alpha animal models antiviral activity antiviral agent Antiviral agents B.1.1.7 Caco2 Calu Calu-3 Cell fusion cell line cell lines cholesterol clinical development COVID-19 pandemic crystal structure D614G E484K Economy effective functional Gamma hACE2 HR1 domain Infection Infectious diseases inhibitor inhibitors intestinal tissues lung Mutation N501Y peptide peptides pseudotyped SARS-CoV-2 public health reduced S protein safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 variant significantly South structural biology target the SARS-CoV-2 transgenic mice Vaccines variant variants Viral viral titer viral titers
[DOI] 10.1038/s41392-021-00712-2 PMC 바로가기 [Article Type] Article

Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay

6,218 개의 약물 및 세포 기반 분석의 가상 스크리닝에 의해 Covid-19에 대한 용도가 변경된 약물

408

Published on 2021-07-272022-08-31
Journal: Proceedings of the National Academy of Sciences of [Category] 신약개발, 치료제,

[키워드] anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity antiviral agent Antiviral agents antiviral drug antiviral drugs antiviral efficacy applied approach approved approved drug approved drugs Calu Calu-3 caused cell-based assay clinical trial clinically Compound Computational methods concentrations COVID-19 COVID-19 pandemic docking docking-based virtual screening drug drug combination drug combinations Drug repurposing drugs Effect Efficacy emodin False positive False positives Health human Calu-3 cells human lung cells IMPROVE infectious viruses inhibit SARS-CoV-2 inhibiting Interaction omipalisib predicted protease recent reduce reduced Remdesivir Replication reported Repurposed drugs resulting risk RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication screened Seven Significance similarity Spread synergistic synergistic effects therapy tipifarnib Toxicity treating COVID-19 Treatment Vero cells Virtual screening viruses
[DOI] 10.1073/pnas.2024302118 PMC 바로가기 [Article Type] 408