Pepinemab antibody blockade of SEMA4D in early Huntington’s disease: a randomized, placebo-controlled, phase 2 trial Research Published on 2022-08-082022-10-05 Journal: Nature Medicine [Category] 바이오마커, 변종, 임상, 치료법, [키워드] 1:1 95% confidence interval antibody assessment baseline blockade Cambridge carrier cognitive Cohort diagnosed disease double-blind Efficacy Endpoint enrolled evaluate Frequency magnetic resonance imaging measure multicenter outcome outcome measure Participants Patient phase 2 trial Placebo placebo-controlled positive Primary outcomes Randomized receive SEMA4D Tapping tomography Treatment treatment-emergent adverse event Trial volumetric [DOI] 10.1038/s41591-022-01919-8 [Article Type] Research
Vaccine based on folded receptor binding domain-PreS fusion protein with potential to induce sterilizing immunity to SARS-CoV-2 variantsSARS-CoV-2 변이체에 대한 살균 면역을 유도할 수 있는 접힌 수용체 결합 도메인-PreS 융합 단백질 기반 백신Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody Response Antigen C-terminus carrier cellular combination vaccine construction convalescent coronavirus COVID-19 COVID-19 pandemic fused fusion protein Genetic genotypes HBV healthy subject healthy subjects hepatitis B Hepatitis B virus human cell human cells IgG IgG antibodies IgG antibody IgG response Immunity immunized in vitro in vivo induce inhibited Interaction maintenance median mucosal secretions Neutralizing Neutralizing antibodies neutralizing antibody neutralizing titers Omicron variant pandemic Protein random Random sample RBD RBD-specific IgG RBD-specific IgG response receptor ACE2 Receptor binding Receptor-binding domain recombinant fusion protein Registered replicate respiratory response responsible robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific antibodies specific IgG antibodies spike Spike protein sterilizing immunity subject subjects subunit Subunit vaccine surface antigen sustained Vaccine Viral viral replication virus entry virus-neutralizing VNT [DOI] 10.1111/all.15305 PMC 바로가기 [Article Type] Article
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article
Whole blood samples for faster real-time PCR analysis of thrombophilic mutations in SARS-CoV-2 virus positive patientsArticle Published on 2022-07-292022-11-16 Journal: Physiological research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Blood blood sample carried carrier carriers Complete Concordance COVID-19 COVID-19 positive patients cycle threshold demonstrated DNA DNA extraction DNA molecule evaluated faster genotyping healthy heterozygote heterozygous homozygote homozygous incidence Laboratory Leiden median Modification Mutation mutations outpatients patients with COVID-19 PCR performed positive positive patient protocol provided real time Real-time PCR reported SARS-CoV-2 virus significant difference significantly subject thawing thrombosis Venous Thromboembolism Whole blood whole blood sample [DOI] 10.33549/physiolres.934883 PMC 바로가기
Myocardial Infarction Following COVID-19 Vaccine Administration: Post Hoc, Ergo Propter Hoc?COVID-19 백신 투여 후 심근 경색: 사후, Ergo Propter Hoc?Case Reports Published on 2022-07-272022-09-12 Journal: Viruses [Category] MERS, 진단, [키워드] absence acute cardiovascular events age all subject Analysis antibody cardiac event carrier coronavirus disease COVID-19 COVID-19 vaccination death determinant effective FIVE Genetic testing genotypes heterogenous histopathological information men Mutation Myocardial Myocardial infarction myocarditis pandemic pathophysiological performed Post-mortem Post-vaccine pro-thrombotic reported Research thrombotic Vaccine vaccine administration while yielding [DOI] 10.3390/v14081644 PMC 바로가기 [Article Type] Case Reports
In Silico Studies on Zinc Oxide Based Nanostructured Oil Carriers with Seed Extracts of Nigella sativa and Pimpinella anisum as Potential Inhibitors of 3CL Protease of SARS-CoV-2SARS-CoV-2의 3CL 프로테아제의 잠재적 억제제로서 Nigella sativa 및 Pimpinella anisum의 종자 추출물을 포함하는 산화아연 기반 나노구조 오일 운반체에 대한 실리코 연구Article Published on 2022-07-042022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 변종, [키워드] 3CL 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition applicability candidate carrier characterized clinical trials Compound compounds conformational change coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 docking explained Extract Health histogram imperative inhibitor investigated Ligand ligands MD simulation mixture molecular molecular docking molecular docking studies molecular dynamic simulation molecular dynamics Molecular dynamics simulation MPro nanostructure Nigella Nigella Sativa Oil oleuropein Oxide pandemic Pimpenella anisum Potential protease Protein Research RMSD RMSF SARS-CoV-2 SARS-CoV-2 main protease seed selected stability structural proteins the SARS-CoV-2 trajectory Vaccines variant Zinc zinc oxide zinc oxide nanoparticles [DOI] 10.3390/molecules27134301 PMC 바로가기 [Article Type] Article
mRNA vaccines: Past, present, futureReview article Published on 2022-07-012022-10-05 Journal: Asian Journal of Pharmaceutical Sciences [Category] 비임상, [키워드] addition adjuvant Cancer candidate carrier Clinical use conventional vaccines COVID-19 Diseases ENhance in vitro Lipid nanoparticles mRNA mRNA stability mRNA vaccine Nanoparticles outcomes Pandemics platform provide provided RNA safety profile shown tissue transcribed Treatment vaccine platform viral disease virus widespread [DOI] 10.1016/j.ajps.2022.05.003 [Article Type] Review article
Safety of Biologic-DMARDs in Rheumatic Musculoskeletal Disorders: A Population-Based Study over the First Two Waves of COVID-19 OutbreakObservational Study Published on 2022-07-012022-10-05 Journal: Viruses [Category] COVID19(2023년), SARS, 임상, [키워드] anti-TNF antiviral drugs Autoimmune biologic carrier Cohort coronavirus disease Corticosteroid Course COVID-19 COVID-19 positive subject disease disorder drug eligible Fever gastro-intestinal General population identify immunosuppressed patients immunosuppressive drug include Infection Italy low dose Mortality Musculoskeletal outbreak pandemic Patient patients treated Prevalence prevalence of COVID-19 protective effect reported rheumatic Safety significant difference small molecule steroid Swab Symptom Symptoms therapy treated Treatment vaccination viral persistence Wave were recorded [DOI] 10.3390/v14071462 PMC 바로가기 [Article Type] Observational Study
Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system원핵생물 발현 시스템에서 기능적으로 활성인 재조합 SARS-CoV-2(COVID-19) 3C 유사 프로테아제 및 가용성 불활성 3C 유사 프로테아제-RBD 키메라의 생산Article Published on 2022-06-202022-09-11 Journal: Epidemiology and Infection [Category] COVID19(2023년), SARS, 치료제, [키워드] 3C-like protease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antigenicity approach blocked carrier cells Chimer chimeric chymotrypsin co-expressed complex coronavirus COVID-19 COVID-19 vaccines cysteine cysteine protease cysteine proteases dimeric disease drug ELISAs enzyme Escherichia coli Escherichia coli BL21 exhibit expression function inactive inhibitors inhibitory main protease non-structural protein non-structural proteins Papain Papain-like protease PLPro polyproteins pp1a pp1ab processing produced Production prokaryotic expression system protease Proteases Protein purification RBD Receptor binding domain RTC SARS-CoV-2 Serine serum severe acute respiratory syndrome Coronavirus solubility Spike protein target tested the Spike Transcription vaccinated individual vaccinated individuals viral replication [DOI] 10.1017/S0950268822001078 PMC 바로가기 [Article Type] Article
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoidsJAK 억제제는 사구체 세포에서 COVID-19 사이토카인 유도 JAK/STAT/APOL1 신호전달 및 인간 신장 오르가노이드에서 족세포병증을 차단합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundantly expressed alleles APOL1 Baricitinib best block blocked capillary carried carrier cause Cell Cell Biology cells collapse controls COVID-19 COVID-19 infection cytokine Cytokines demonstrated Endothelial cell endothelial cells expression glomerular glomerular capillaries human kidney Infection inhibitor iPS cells. JAK inhibitor jak inhibitors JAK/STAT JAK/STAT pathway JAK/STAT signaling JAK1 kidney Kidney disease knowledge majority mechanism Nephrology nephropathy Organoid organoids pathogenic Patient phenotype podocyte Podocytes Protein reduced rescued resulting risk SARS-CoV-2 Signaling STAT Support Therapeutic benefit therapeutic benefits Trigger viability [DOI] 10.1172/jci.insight.157432 PMC 바로가기 [Article Type] Article