Cathepsins – Page 2 – Communicable Diseases Research

Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19

COVID-19에 대한 치료 전략으로 SARS-CoV-2 프로테아제를 표적화하기 위한 과제

Article

Published on 2021-06-112022-09-11
Journal: ACS Infectious Diseases
[Category] MERS, SARS, 진단, 치료제,

Role of host factors in SARS-CoV-2 entry

SARS-CoV-2 진입에서 숙주 요인의 역할

Review

Published on 2021-05-282022-09-10
Journal: The Journal of Biological Chemistry
[Category] SARS, 유전자 메커니즘,

[키워드] ACE2 ACE2, angiotensin converting enzyme 2 addition addressed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen binding C-type lectins Cat B/L, cathepsin B/L cathepsin cathepsin B Cathepsins CD147 CD147, cluster of differentiation 147 Cell cofactor cofactors complex coronavirus Cyp A/B, cyclophilin A/B determine disrupt endocytosis ENhance entry cofactor examined Factor Factors feature HCoV, human coronavirus heparan sulfate highlighting highly pathogenic Host host cell host cell membrane host protease host proteases HSPG, heparin sulfate proteoglycan human coronaviruses human population identify IFITM, interferon-induced transmembrane proteins interferon ISG, Interferon-stimulated gene locus Ly6E, lymphocyte antigen 6E lymphocyte mechanism membrane fusion MERS-CoV, Middle East respiratory syndrome coronavirus MHV, mouse hepatitis virus neuropilin Neuropilin-1 NRP-1, neuropilin-1 pathogenicity Phosphatidylserine plasma membrane protease proteoglycans PS, phosphatidylserine RBD, receptor binding domain recent receptor receptors RNA virus role SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 pandemic SARS-CoV-2 receptor SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus Serine serine 2 sialic acids Spike protein sulfate the cell the SARS-CoV-2 TIM-1, T-cell immunoglobulin and mucin domain 1 TMPRSS2 TMPRSS2, transmembrane protease, serine 2 transmembrane transmembrane protease serine 2 transmembrane protein unique Viral viral envelope viral spike protein virus entry virus receptor zoonotic transmission
[DOI] 10.1016/j.jbc.2021.100847 PMC 바로가기 [Article Type] Review

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2

SARS-CoV-2 진입의 Hydroxychloroquine 매개 억제는 TMPRSS2에 의해 약화됩니다

Research Article

Published on 2021-01-192022-08-13
Journal: PLoS Pathogens
[Category] COVID-19, Medicine and Health Sciences,

[키워드] ablated activate activated activating antiviral activities antiviral activity Autoimmune disorders block cathepsin L Cathepsins cause Cell cell entry cell surface cell-culture studies cell-culture systems Chloroquine cleave clinically Combination combinations coronavirus COVID-19 COVID-19 patient dependent on Efficacy endocytosis Endosomal acidification endosomal protease explain functional furin furin cleavage site furin-cleavage site global public health human clinical trial human clinical trials Hydroxychloroquine identify in vivo Infection inhibit inhibit SARS-CoV-2 interfere introduced lack malaria membrane fusion observé pathogenic coronavirus pathway plasma plasma membrane Prevent protease TMPRSS2 Protein Proteins proteolytic activity Receptor binding reversed S protein S proteins SARS Coronavirus SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 S protein SARS-CoV-2 spike shown target cell target cells tested the cell the SARS-CoV-2 these compounds TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 pathway treat treated treatment for COVID-19 utility Viral viral entry viral infection
[DOI] 10.1371/journal.ppat.1009212 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

Research Article

Published on 2021-01-042022-10-31
Journal: eLife
[Category] COVID-19,

Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics

Cellular and Infection Microbiology

Published on 2020-12-082022-10-31
Journal: Frontiers in Cellular and Infection Microbiology
[Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome addition antigen processing Apoptosis ARDS Atherosclerosis cathepsin cathepsin L Cathepsins Cell chronic inflammation coronavirus coronavirus disease COVID-19 COVID-19 patients cysteine protease Cytokine storm Deterioration detrimental diabetes discomfort disease Diseases drug enzyme etiology expression Extracellular matrix host cells host genetics Immunological response immunopathological implicated Infection infections inflammatory status inhibiting Invasion involved late stage lung lysosomal MERS-CoV Metastasis multiple organ failure other diseases Pandemics pathological condition physiological renal respiratory robust SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein the disease therapeutic target treat tumors up-regulated viral infection
[DOI] 10.3389/fcimb.2020.589505 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

SARS-CoV-2는 인간 심근세포를 감염시키고 세포독성 효과를 유도합니다

Article

Published on 2020-12-012022-09-11
Journal: Cardiovascular Research
[Category] MERS, SARS, 진단, 치료기술, 치료법, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral drug Apoptosis blocked Caco-2 cardiac injury cardiomyocyte Cardiosphere Cardiotoxicity cathepsin cathepsin-dependent Cathepsins caused cell lines Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytotoxic effect demonstrated dependent on direct infection double-stranded Effect elevated enzyme expression global pandemic glycoprotein heart Heart slice higher risk in vitro Increasing induce infect Infection infection with SARS-CoV-2 infections Inflammation inhibited Injury interferon lead Lung injury marker Mortality oxygen Particle pathway Pathways Patient reactive oxygen Remdesivir respiratory RNA sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. secondary to severe acute respiratory syndrome Coronavirus spike glycoprotein Spike protein strain Stress supernatant supernatants tissue transcriptional response up-regulation Viral viral infection viral particle Viral particles Viral RNA viral spike viral spike protein
[DOI] 10.1093/cvr/cvaa267 PMC 바로가기 [Article Type] Article

The Pathophysiology of Gastrointestinal and Hepatic Manifestations of COVID-19

Internal Medicine

Published on 2020-11-252022-10-31
Journal: Cureus
[Category] COVID-19,

[키워드] absence ACE2 ACE2 receptor acute respiratory syndrome angiotensin-converting enzyme 2 anorexia Atypical case sery Cathepsins coronavirus Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 demonstrated diarrhea elevated elevated liver enzyme Evidence facilitate Gastrointestinal gastrointestinal and hepatic manefestations Gastrointestinal symptom gastrointestinal tract hepatic hygiene increasingly infect inflammatory markers international public health laboratory abnormality lack literature review liver manifestation Nasopharyngeal swab nasopharynx nausea organ system Pathogenesis Patient polymerase chain protease receptor Respiratory illness respiratory symptoms reverse transcription RT-PCR SARS-CoV-2 sars-cov-2 (severe acute respiratory syndrome coronavirus -2) SARS-CoV-2 infected patient SARS-COV-2 infection Stool Symptoms test negative TMPRSS2 transaminitis transmembrane Transmission viral entry Viral RNA viral shedding while
[DOI] 10.7759/cureus.11698 PMC 바로가기 [Article Type] Internal Medicine

The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors

코로나바이러스 세포 진입 및 복제에서 시스테인 펩티다제의 역할: 카텝신 억제제의 치료 가능성

Review

Published on 2020-11-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, COVID-19,

[키워드] Activation antiviral drug cathepsin inhibitor Cathepsins cell entry cells chymotrypsin Coronaviral coronavirus coronavirus CoV CoVs cysteine Diseases generate Host host cell humans inhibitor involved lysosomal nonstructural protein nonstructural proteins Nsps outcomes over Papain peptidase positive-sense prevalent processed replicase polyprotein replicase polyproteins Replication respiratory respiratory diseases RNA viruses severe respiratory diseases single-stranded spike glycoprotein spike glycoproteins Spike protein targets therapeutic potential treatment strategy utilization Viral Viral RNA viral RNA synthesis virus attenuation
[DOI] 10.1371/journal.ppat.1009013 PMC 바로가기 [Article Type] Review

COVID-19: Targeting Proteases in Viral Invasion and Host Immune Response

Molecular Biosciences

Published on 2020-10-092022-10-31
Journal: Frontiers in Molecular Biosciences
[Category] COVID-19,

[키워드] absence accelerated ACE2 administration antiviral drug approach Cathepsins caused chemokine clinical evidence coronavirus COVID-19 cytokine globe help Host Host immune response host immunity immune reaction immune response immune system in viral Infection infections inflammatory cell information Invasion involved knowledge MERS Perspective plasma Predictive promoted protease protease inhibitors Proteases proteolytic Research respiratory disorder response SARS-CoV-2 SARS-CoV-2 viral severity Spread suggested target protease targeting therapeutic response TMPRSS2 tracing vaccination virus
[DOI] 10.3389/fmolb.2020.00215 PMC 바로가기 [Article Type] Molecular Biosciences

SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells

Review

Published on 2020-08-092022-10-29
Journal: International Journal of Molecular Sciences
[Category] COVID-19,