CD147 – Page 2 – Communicable Diseases Research

Computational Modeling of T Cell Hypersensitivity during Coronavirus Infections Leading to Autoimmunity and Lethality

자가 면역 및 치사율로 이어지는 코로나바이러스 감염 중 T 세포 과민증의 전산 모델링

Article

Published on 2022-03-222022-09-11
Journal: Computational and Mathematical Methods in Medicine
[Category] SARS, 변종,

Comparative study of SARS-CoV-2 infection in different cell types: Biophysical-computational approach to the role of potential receptors

다양한 세포 유형에서 SARS-CoV-2 감염에 대한 비교 연구: 잠재적 수용체의 역할에 대한 생물물리학적 전산적 접근

Article

Published on 2022-03-012022-09-12
Journal: Computers in biology and medicine
[Category] MERS, SARS, 진단,

[키워드] A549 ACE2 addition AGTR2 angiotensin-converting enzyme 2 approach CD147 Cell cell line cell lines Cell susceptibility cellular Comparative conditions dependent on docking early infection expected experiment expression expression level expression levels greater Heat shock HEK293 HepG2 Host host protein HSPA5 Infection Interaction kinetic less Lungs macromolecular Macromolecular crowding membrane NRP1 NTERA-2 parameter predict predicted promote protease Protein Quantitative receptor receptors Research respiratory tract SARS CoV-2 SARS-COV-2 infection serine 2 stimulate susceptibility TMPRSS2 transcriptomic data transmembrane viral dynamics viral growth viral spike Viral spike. virus
[DOI] 10.1016/j.compbiomed.2022.105245 PMC 바로가기 [Article Type] Article

A Deadly Embrace: Hemagglutination Mediated by SARS-CoV-2 Spike Protein at Its 22 N-Glycosylation Sites, Red Blood Cell Surface Sialoglycoproteins, and Antibody

Review

Published on 2022-02-252022-10-29
Journal: International Journal of Molecular Sciences
[Category] COVID-19,

SARS-CoV-2 Infects Red Blood Cell Progenitors and Dysregulates Hemoglobin and Iron Metabolism

SARS-COV-2는 적혈구 전구체를 감염시키고 헤모글로빈과 철 대사를 조절시킨다

Article

Published on 2022-02-182022-09-10
Journal: Stem cell reviews and reports
[Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] accompanied ACE2 receptor acute respiratory distress aggravate Alpha analyzed Anemia Bilirubin Blood Blood samples cause CD147 Cell cells Coagulopathies Coagulopathy concentrations contribute Course COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients death Degradation diagnostic differentiation door dysregulation erythroid Erythroid precursors expansion Express ferritin HAMP healthy donor healthy donors heme hemoglobin Hemoglobin biosynthesis Hemoglobin degradation hepcidin homeostasis hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia identify impair in vitro infect inhibit iron Iron metabolism mass spectrometry metabolism Mortality mRNA expression multiorgan failure opens oxygen Peripheral blood precursor progenitor qPCR analysis Raman Trapping Microscopy RBC RBCs Red red blood cell red blood cells reduced respiratory distress Result SARS-CoV-2 SARS-COV-2 infection serum Serum ferritin severe COVID-19 disease severely ill COVID-19 patients severity Spectroscopy stem cell stem cells susceptible Therapeutic strategies total bilirubin Transferrin variant were infected Whole blood Zinc
[DOI] 10.1007/s12015-021-10322-8 PMC 바로가기 [Article Type] Article

Increased Expression of Tim-3 Is Associated With Depletion of NKT Cells In SARS-CoV-2 Infection

Tim-3의 발현 증가는 SARS-CoV-2 감염에서 NKT 세포의 고갈과 관련이 있습니다

Immunology

Published on 2022-02-162022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Apoptosis binding caspase caused CD147 CD26 Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients CTLA-4 DCs decrease demonstrated dendritic cell dendritic cells Depletion disease severity dysfunction expressed expression expression level Genes healthy individuals IFN-γ IL-10 IL-12 IL-4 immune responses Immunopathogenesis implication Increased increased expression LAG-3 large cohort mechanism mitochondrial mitochondrial gene mitochondrial genes natural killer NKT NKT cell NKT cells outcome patients with COVID-19 PD-1 positively correlated Prognosis progression stage promote receptor receptors respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike scRNA-seq secrete secreted Sequencing analysis severe acute respiratory syndrome Coronavirus severity and prognosis Single-cell RNA sequencing stages therapeutic strategy TIM-3 up-regulated
[DOI] 10.3389/fimmu.2022.796682 PMC 바로가기 [Article Type] Immunology

Ferristatin II Efficiently Inhibits SARS-CoV-2 Replication in Vero Cells

Brief Report

Published on 2022-02-032022-10-28
Journal: Viruses
[Category] COVID-19, COVID19(2023년), SARS,

[키워드] A significant reduction ACE2 acute respiratory syndrome affected block CD147 Cell Concentration confocal microscopy consequence coronavirus COVID-19 Culture D614G Degradation Delta demonstrated distribution domain ferristatin II global public health host cells induce Infection inhibited mechanism medium Multiple Neuropilin-1 non-toxic omicron Protein RBD RBD protein receptor Receptor-binding domain (RBD) replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 host cell SARS-COV-2 infection SARS-CoV-2 receptors SARS-CoV-2 variant significantly spike the SARS-CoV-2 therapeutic strategy Transferrin transferrin receptor 1 Treatment Vero Vero Cell Vero cells viability viral entry virus virus inhibition Wuhan
[DOI] 10.3390/v14020317 PMC 바로가기 [Article Type] Brief Report

The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies

COVID-19 관련 신경퇴행성 질환에서 Eph 수용체, 뉴로필린-1, P2X7 및 CD147의 역할: 잠재적으로 유망한 치료법으로서 인플라마솜 및 JaK 억제제

Review

Published on 2022-02-022022-09-10
Journal: Cellular & Molecular Biology Letters
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alzheimer’s disease angiotensin Angiotensin-converting enzyme antiviral drug antiviral drugs CD147 Central nervous system CNS conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokines demonstrated Diseases effective entry receptor entry route Ephrin explain expression help host cells Inflammasome inhibitor Interaction Invasion involved Jak Ligand mechanisms neurodegenerative Neurodegenerative diseases neurodegenerative disorder neurodegenerative disorders neuropilin neuropilin 1 Neuropilin-1 Novel coronavirus novel coronavirus disease novel vaccines P2X7 pandemic Parkinson’s disease Pathogenesis pathological mechanism Protein provide receptor receptors respiratory Safe SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spread therapeutic strategy therapy Vaccine Vaccines with COVID-19
[DOI] 10.1186/s11658-022-00311-1 PMC 바로가기 [Article Type] Review

Interaction of SARS-CoV-2 with cardiomyocytes: Insight into the underlying molecular mechanisms of cardiac injury and pharmacotherapy

SARS-CoV-2와 심근세포의 상호작용: 심장 손상 및 약물 요법의 기본 분자 메커니즘에 대한 통찰력

Review

Published on 2022-02-012022-09-11
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar
[Category] COVID19(2023년), SARS, 치료제,

[키워드] Abnormalities accessory protein accessory proteins ACE2 adopted advent arteries blood cell calcium cardiac cardiac disease cardiac injuries cardiomyocyte cause CD147 circulating complications Coronary arteries COVID-19 COVID-19 patient dysfunction electrical exhibited Express Extracellular vesicles facilitate heart help homeostasis Infection Injury insight integrin Interaction involved Lungs Manifestations manifested mechanism molecular mechanism pathway Pathways pericyte pericytes pharmacotherapy PROTECT Protein receptor reduced Respiratory illness ROS production SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 vaccines severe COVID-19 Side effect Side effects signaling pathway Spectrum subject Support the SARS-CoV-2 TMPRSS2 Treatment Vaccine vaccine. virus
[DOI] 10.1016/j.biopha.2021.112518 PMC 바로가기 [Article Type] Review

Molecular basis of the potential interaction of SARS-CoV-2 spike protein to CD147 in COVID-19 associated-lymphopenia

Article

Published on 2022-02-012023-07-06
Journal: Journal of biomolecular structure & dynamics
[Category] COVID19(2023년),

[키워드] CD147 docking lymphopenia SARS-CoV-2 Spike.
[DOI] 10.1080/07391102.2020.1822208 PMC 바로가기

Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells

인간 폐 조직 세포에서 SARS-CoV-2 진입, 염증 및 새로운 치료제 평가

Research Article

Published on 2022-01-132022-09-10
Journal: PLoS Pathogens
[Category] SARS, 변종, 신약개발, 치료제,

[키워드] ACE2 ACE2 expression alveolar Alveolar Type II anti-inflammatory compound anti-inflammatory compounds anti-SARS-CoV-2 therapeutics Antiviral antiviral activity antiviral drug approaches Behavior can be used candidate CD147 Cell Cell culture cell cultures cell lines cell suspension cells cellular complexity Compound drug candidate Drug evaluation early stage early stages expression Factors growth heterogeneous host-pathogen interaction host-pathogen interactions human lung tissue identify immortalized cell lines immune in viral in vitro Infection Inflammation inhibitor interferon interferons involved Laboratory local inflammatory response lung cell modulate modulated offer overcome pathogen Pathogens physiological platform populations primary cell primary cells primary human cell primary human cells Protein provide required respiratory Respiratory pathogens reveal SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 variants Stimulation surgical resection susceptible cell target Therapeutics TMPRSS2 Viral viral entry viral infection
[DOI] 10.1371/journal.ppat.1010171 PMC 바로가기 [Article Type] Research Article