CD8+ T cell – Page 2 – Communicable Diseases Research

Heterogenous CD8+ T Cell Maturation and ‘Polarization’ in Acute and Convalescent COVID-19 Patients

Article

Published on 2022-08-282022-11-15
Journal: Viruses [Category] SARS, 진단, 치료기술, 치료제,

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Specific T Cells and Antibodies in Coronavirus Disease 2019 (COVID-19) Protection: A Prospective Study

중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 특이적 T 세포 및 항체, 코로나바이러스 질병 2019(COVID-19) 보호: 전향적 연구

Article

Published on 2022-08-242022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed antibody Antibody Response Antibody responses CD4+ CD8+ T cell CD8+ T cells clinical comparable coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 demonstrated ELISPOT enzyme enzyme-linked immunosorbent evaluated flow cytometry followed by fraction Fractions frequencies Frequency healthcare highest IFN-γ IgG immune immune response Immunoglobulin Immunoglobulin G immunoglobulin M individual Infection interferon gamma interleukin interleukin 2 Kaplan-Meier estimator membrane nucleocapsid pandemic positive Probability Prospective PROTECT protective effect question Registration respiratory response SARS-CoV-2 SARS-COV-2 infection Spike protein Spike proteins staining T cell T cells T-cell T-cell and antibody responses T-cell Response T-cell responses the SARS-CoV-2 virus virus-specific antibodies Virus-specific IgG were infected with infection
[DOI] 10.1093/cid/ciac278 PMC 바로가기 [Article Type] Article

Viral immunogenic footprints conferring T cell cross-protection to SARS-CoV-2 and its variants

SARS-CoV-2 및 그 변이체에 T 세포 교차 보호를 부여하는 바이러스 면역원성 발자국

Article

Published on 2022-07-282022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종,

[키워드] 229E 3D structure 3D Structures approach Asymptomatic case Asymptomatic cases CD8+ T cell cellular cellular response concern conserved contributing to Coronaviruses COVID-19 cross-protection cross-reactivity death disease Endemic epitope Epitopes examination expected explain explanation Features Genetic Heterologous HLA-A HLA-A*02:01 human coronaviruses human coronaviruses 229E human infection Immunity immuno informatics immunogenic immunogenic feature immunogenicity include indicate individual individuals infected individuals Infection involved molecular OC43 other coronaviruses outcomes pathogen Pathogens peptide peptides physicochemical Population SARS-CoV SARS-CoV-2 SARS-CoV-2 peptides SARS-CoV-2 sequence sequence Sequence analysis severe disease Structural analysis Structure T cell T-cell T-cell epitopes target Trigger uninfected Vaccine development variant variants virus viruses Wuhan
[DOI] 10.3389/fimmu.2022.931372 PMC 바로가기 [Article Type] Article

Immune Cells Profiles In The Peripheral Blood Of Patients With Moderate To Severe COVID-19 And Healthy Subjects With and Without Vaccination With The Pfizer-BioNTech mRNA Vaccine

Pfizer-BioNTech mRNA 백신 접종 여부에 관계없이 중등도에서 중증 COVID-19 환자 및 건강한 피험자의 말초혈 면역 세포 프로필

Article

Published on 2022-07-112022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive analyzed B cell B cells Blood causative agent caused CD14 CD16 CD19 CD19+ CD3+ CD4+ CD4+ T cells CD4+ T lymphocyte CD56 CD56+ CD8+ T cell CD8+ T cells clinical manifestations coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients detectable determine dysregulated flow cytometry Frequency group healthy control healthy subject healthy subjects HLA-DR host response immune Immune cell immune cells immune response Inflammatory Kuwait lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes moderate moderate to severe monocyte monocyte subsets Monocytes mRNA mRNA vaccine NK cell NK cells no symptom no symptoms percentage percentages peripheral Peripheral blood Perturbation perturbations Pfizer Pfizer-BioNTech profile profiles PROTECT required respiratory SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease significantly higher significantly lower subjects subset T cells T lymphocytes the patient three group three groups vaccination was performed with COVID-19
[DOI] 10.3389/fimmu.2022.851765 PMC 바로가기 [Article Type] Article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Research

Published on 2022-07-042022-10-05
Journal: Nature biomedical engineering [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료법, 치료제,

In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19

다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다

Article

Published on 2022-07-012022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커,

[키워드] (PD-1 acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed Anosmia anti-CD3 Antibody titer Antibody titers basal baseline characteristics biochemical blood sample Blood samples CD14 CD16 CD4+ CD8+ T cell CD8+ T cells Cellular immune response cellular immunity classical classical monocytes clinical recovery conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression disease display distress drug Evidence exposure expression Fever Follow-up headache healthy volunteer Human Humoral immunity hypoxia IFN-alpha IFN-gamma IL-2 immune function immune response Immunoglobulin Immunoglobulin G Impaired in vitro interferon interleukin interleukin-2 Invasive mechanical ventilation lipopolysaccharide Mild mild cases monocyte monocyte subsets Monocytes Neutralizing no difference no differences non-classical monocyte Non-classical monocytes not differ participant Patient PD-1 Pneumonia polyclonal predisposition programmed cell death programmed cell death protein prospective cohort study Protein receiving Registered required respiratory respiratory distress response S1 protein SARS-CoV-2 SARS-COV-2 infection serum titer Severe case severe cases severe COVID-19 severity significantly subset Symptom T cell T cells virus worsening
[DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article

T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells

소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.

Article

Published on 2022-06-292022-09-11
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술,

[키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T helper TCRs virus
[DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article

Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells

Article

Published on 2022-06-202024-08-29
Journal: Mol Brain [Category] 말라리아,

[키워드] ACSL4 CD8+ T cell cerebral malaria Ferroptosis GPX4 Neuron TfR1.

Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern

Research

Published on 2022-06-092022-10-05
Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 임상, 치료기술,

Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19

치명적인 COVID-19에서 연령 관련 위험 및 폐포 손상의 면역 및 상피 결정인자

Article

Published on 2022-06-082022-09-12
Journal: JCI Insight [Category] MERS, 진단,