SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent mannerArticle Published on 2022-09-292022-11-15 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 adipose Adiposity anatomical Cell cell death cells cellular response Disease progression Express expression fat fat cell infect Infection Lineage occur pro-inflammatory cytokines risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 susceptibility susceptible the SARS-CoV-2 tissue variant viability visceral [DOI] 10.1038/s41467-022-33218-8 PMC 바로가기
NSP4 and ORF9b of SARS-CoV-2 Induce Pro-Inflammatory Mitochondrial DNA Release in Inner Membrane-Derived VesiclesArticle Published on 2022-09-232022-11-16 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] airway epithelial cells anti-apoptotic approach BCl2 BCL2 antagonist/killer caused cell death cell-free mitochondrial DNA changes co-culture co-cultured COVID-19 COVID-19 patient Effect Effects epithelial cells functional induce inhibit Inner Interaction intercellular intercellular mitochondrial transfer knockdown MCL1 mechanism membrane vesicle mitigate mitochondrial mitochondrial DNA Mortality MSC MSCs myeloid cell myeloid cell leukemia-1 nsp4 Orf9b outer membrane overexpression plasma pro-apoptotic pro-inflammatory Protein Release reversed SARS-CoV-2 SARS-CoV-2 protein screened significantly stem cell therapeutic Therapeutic approach these cell transfer Treatment tunneling nanotubes. [DOI] 10.3390/cells11192969 PMC 바로가기
Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular DiseaseArticle Published on 2022-09-012022-11-16 Journal: Cells [Category] 유전자 메커니즘, [키워드] alleviate antioxidants Arrhythmias Atherosclerosis Cardiomyopathy cardiovascular cardiovascular disease Cell cell death characterized conditions Critical CVD cytoplasmic Defense demonstrated detoxify DHODH enzyme activity Evidence expected Fenton reaction Ferroptosis genetic manipulation heart failure implication induce inhibitors Injury involved iron lipid peroxidation LOX membrane mitochondria. mitochondrial mitochondrial membrane molecular mechanism Pathogenesis Pathways peroxidase Protein regulated Relevance ROS therapeutic option [DOI] 10.3390/cells11172726 PMC 바로가기
Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike ProteinArticle Published on 2022-08-302022-11-16 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ADAM10 addition bind Cell cell death cell interaction cleavage cleaved complex condition contributed coronavirus SARS-CoV COVID-19 develop domain effective element endosomal pathway entry pathway evade furin furin cleavage motif highly pathogenic Host host protease human coronaviruses identify Immunity independent Infection infection mechanism inhibitor involved membrane membrane fusion metalloproteinase organ damage Pathogenesis pathogenesis of COVID-19 pathway Prevent priming provide required S1/S2 boundary S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein selective sequence siRNAs Site spike Spread surface surface receptor syncytium formation the spike protein therapeutic agent therapeutic target Therapies TMPRSS2 unique vaccination variants virus entry Virus entry. virus variant [DOI] 10.1128/mbio.00519-22 PMC 바로가기
NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study패혈성 쇼크 및 심각한 COVID-19 환자의 NETosis 및 뉴클레오솜 바이오마커: 관찰 연구Observational Study Published on 2022-07-272022-09-11 Journal: Biomolecules [Category] MERS, 바이오마커, 임상, [키워드] alternative Biomarker Biomarkers cell death conditions Control control subject COVID-19 Critical critical COVID-19 patient critical COVID-19 patients Defense discrimination disease severity evaluate extracellular trap histone ICU Infection Intact intensive care intensive care unit marker matched control mechanism microorganisms MPO myeloperoxidase NET NETosis NETs NETs’ formation neutrophil neutrophil activation neutrophil count Neutrophil elastase Neutrophil extracellular traps Neutrophils normalization Nucleosome nucleosomes P -value p -values patient cohort patients phagocytosis recruited Result SARS-CoV-2 septic Septic shock Septic shock. Significant significant differences Spread subject were measured [DOI] 10.3390/biom12081038 PMC 바로가기 [Article Type] Observational Study
Platelet proteome reveals features of cell death, antiviral response and viral replication in covid-19 Research Published on 2022-07-162022-10-05 Journal: Cell Death Discovery [Category] 치료기술, [키워드] affected antiviral response approach biological processe CD147 cell death changes in complex contribute Coronavirus disease 2019 correlated COVID-19 COVID-19 pathogenesis COVID-19 patient dataset deaths described differentially expressed disease severity experiment expression feature FIVE identify individuals Infection interferon nonsurvivors outcome Pathogenesis pathway patient cohort patients performed Platelet platelet activation Protein proteome proteomic proteomics response reveal SARS-CoV-2 sequenced Significant survivor the SARS-CoV-2 genome thrombosis translation viral replication [DOI] 10.1038/s41420-022-01122-1 [Article Type] Research
Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation바이러스 감염, 세포 사멸 및 염증에서 SARS-CoV-2 뉴클레오캡시드 단백질의 신호 전달 메커니즘Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] activating acute respiratory syndrome acute respiratory syndrome coronavirus assembly caused cell cycle cell cycle arrest cell death complex complexes coronavirus COVID-19 Critical Cytokine storms Cytokines ENhance expression facilitate genomic RNA global public health GSDMD IFN-β in viral induce Infection Inflammation inhibit innate immune system life cycle mechanism N protein NF-κB NF-κB signaling NLRP3 NLRP3 inflammasome pathway Proinflammatory cytokine proinflammatory cytokines promote Protein pyroptosis Replication resulting RNA RNAi RNAi pathway SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 nucleocapsid severe acute respiratory syndrome Coronavirus Signaling Smad3 stress granule stress granules survival Transcription undergo viral genome viral life cycle viral replication Viral RNA virus worldwide pandemic [DOI] 10.7150/ijbs.72663 PMC 바로가기 [Article Type] Review
Identification of potential COVID-19 treatment compounds which inhibit SARS Cov2 prototypic, Delta and Omicron variant infectionSARS Cov2 원형, Delta 및 Omicron 변이체 감염을 억제하는 잠재적인 COVID-19 치료 화합물의 식별Article Published on 2022-07-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료법, 치료제, [키워드] Anti-viral drug repurposing apilimod approach approach berbamine candidate drug cell death Cepharanthine clinical trial clinically Compound compounds COVID-19 COVID19 crizotinib Delta drug drug candidate effort FDA approval followed by Health identification Infection inhibit inhibited inhibitory effect less library multiple cell lines omicron Omicron variant Omicron variants Probability pseudovirus entry Recurrent replicated repurposing required robustness safety profile SARS CoV2. screened stratified Treatment Validity variant [DOI] 10.1016/j.virol.2022.05.004 PMC 바로가기 [Article Type] Article
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary InflammationZ-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할Review Published on 2022-06-282022-09-11 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity innate immunity. Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus virus Z-RNA ZBP1 zoonotic transmission [DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review
Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19세포 사멸: COVID-19의 병인 및 중재 요법에 대한 참여Review Published on 2022-06-132022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis autophagy caused Cell cell death coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease disease pathogenesis Effective strategies effective strategy Ferroptosis homeostasis Host Increasing indicated Infection Interaction Intervention involved Involvement knowledge lack mechanism necroptosis NETosis Occurrence pandemic Pathogenesis pathogenicity pathology present Prevent progression pyroptosis SARS-CoV-2 severe acute respiratory syndrome Coronavirus Therapies therapy treat virus infection [DOI] 10.1038/s41392-022-01043-6 PMC 바로가기 [Article Type] Review