Antidepressants promote the spread of extracellular antibiotic resistance genes via transformation Research Published on 2022-07-282022-10-05 Journal: ISME Communications [Category] 변종, 유전자 메커니즘, [키워드] accelerate Acinetobacter Antibiotic resistance antibiotic resistance gene antidepressant antimicrobial Arg ARGs ATP Bupropion cell membrane clinically Concentration demonstrated dissemination Duloxetine Extracellular Fluoxetine Gut Health Human increasingly Interaction microbial community potential risk promote reactive oxygen species Result sertraline significantly SOS response Spread stimulated Stress Transcription transfer translation [DOI] 10.1038/s43705-022-00147-y [Article Type] Research
Drug-Target Network Study Reveals the Core Target-Protein Interactions of Various COVID-19 TreatmentsArticle Published on 2022-07-062022-10-04 Journal: Genes [Category] COVID19(2023년), SARS, 신약개발, [키워드] Analysis Bronchoalveolar lavage fluid cascade caused Cell cell membrane conducted core coronavirus disease COVID-19 COVID-19 symptom CTD curated database death rate Diseases downstream cellular signaling drug Drug discovery drug treatment drug-target drug-target network drugs effort function Genes Human interconnected genes involved knowledge lung Macrophage medications mitigate network Numerous overlapped overlapping pandemic pharmacological target PPI protein-protein interaction receptors reduce risk SARS-CoV-2 virus severe COVID-19 significantly single-cell Symptom T cell target gene text mining Text mining. [DOI] 10.3390/genes13071210 PMC 바로가기 [Article Type] Article
The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2SARS-CoV-2의 스파이크 단백질은 지질 대사를 손상시키고 지방독성에 대한 감수성을 증가시킵니다: Nrf2의 역할에 대한 의미Article Published on 2022-06-142022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alterations autophagic autophagic pathway autophagy Cell cell line cell membrane cell membranes control cell control cells controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dose-dependent manner dysregulation exhibited expression expression profile Ferroptosis Gene Expression Gene expression profiles HEK293 host cells impair increase inhibitor investigated Lipid lipid metabolism lipotoxicity mechanism metabolism molecules multifunctional Necrosis Nrf2 nuclear palmitic acid pathway Patient Protein role SARS-CoV-2 severe acute respiratory syndrome Coronavirus significant increase spike Spike protein spike protein. suppressed susceptibility the Spike transcriptional trigonelline upregulation was used [DOI] 10.3390/cells11121916 PMC 바로가기 [Article Type] Article
Periodontitis promotes the expression of gingival transmembrane serine protease 2 (TMPRSS2), a priming protease for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)치주염은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)에 대한 프라이밍 프로테아제인 치은 막횡단 세린 프로테아제 2(TMPRSS2)의 발현을 촉진합니다Article Published on 2022-06-012022-09-11 Journal: Journal of oral biosciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome Analysis analyzed anti-TMPRSS2 antibody cell membrane ChIP coronavirus correlation COVID-19 dataset datasets ESR1 Estrogen estrogen receptor Express expressed expression Gene Expression Gene Expression Omnibus GEO GEO dataset Gingiva Human increase increased expression investigated keratinocytes Ligand oral cavity Periodontitis priming promote promoter promoter region protease Quantitative responsible reverse transcription SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2. screened Serine Spike protein the SARS-CoV-2 tissue tissues TMPRSS2 TMPRSS2 expression transcription factor transcription factors transmembrane serine protease transmembrane serine protease 2 was performed western blot Western blot analysis [DOI] 10.1016/j.job.2022.04.004 PMC 바로가기 [Article Type] Article
Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19펩티드 기반 치료제: COVID-19에 대한 새로운 잠재적 치료제Review Published on 2022-05-012022-09-11 Journal: Thérapie [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] antimicrobial peptide antiviral activity Antiviral agents blocked causative agent cell membrane cleave clinical trials COVID-19 COVID-19 outbreak drug drugs feasibility form fusion hACE2 host cell host cell membrane Human humans In silico method inhibitor Interaction intestine intestines lactoferrin lung Lungs mechanism MERS outbreak pandemic peptide peptide-based peptides Peptides-based therapeutics positive-sense RNA virus potential therapeutic agent RNA virus S protein S protein-hACE2 interaction S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2. shown the S1 subunit the SARS-CoV-2 therapeutic viral envelope viral infection [DOI] 10.1016/j.therap.2021.09.007 PMC 바로가기 [Article Type] Review
Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation안지오텐신 전환 효소 2(ACE2): 20년 간의 폭로와 재평가Review Published on 2022-05-012022-09-11 Journal: Peptides [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE ACE2 acting Amino acid amyloid angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme-2 binding cardiovascular caused cell membrane cell type conversion coronavirus counterbalance COVID COVID-19 pandemic driving ectoenzyme enzyme event expressed Factor homology implicated Inflammatory mechanisms membrane protein neprilysin pathological conditions Pathologies pathology Pathways peptide peptides physiological producing Protective provide provided receptor regulate Renin renin-angiotensin system sACE2 SARS SARS virus SARS-CoV2 specificity susceptibility therapeutic target Transport Treatment Vascular Vasoactive Vasopeptidase. virus Zinc [DOI] 10.1016/j.peptides.2022.170766 PMC 바로가기 [Article Type] Review
Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion중화 단일 클론 항체는 막 융합 차단을 통해 SARS-CoV-2 감염을 억제합니다Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antigenic epitope Antisera blocking cell membrane collected conserved COVID-19 therapeutics Delta Effectiveness epitope epitope peptide Epitopes Epsilon exhibited fusion Gamma immunized immunodominant Infection inhibit SARS-CoV-2 inhibited membrane membrane fusion mice MOST Mutation NAb NAbs Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody peptides Protein RBD RBD sequence RBD sequences Receptor binding Receptor binding domain reduced S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-like coronaviruses sequence spike (S) protein. the RBD the S protein the SARS-CoV-2 unique Vaccine Vaccines variants virus virus entry [DOI] 10.1128/spectrum.01814-21 PMC 바로가기 [Article Type] Article
Molecular Interactions of Tannic Acid with Proteins Associated with SARS-CoV-2 InfectivityArticle Published on 2022-02-272022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] 3CLpro ACE2 acid acute respiratory syndrome angiotensin-converting enzyme 2 approach bind binding biochemical building cell membrane Combination Compound coronavirus coronavirus disease COVID-19 Effect Extracellular higher affinity Host Infectivity inhibit Inhibition assays inhibitors Interaction involved Ligand molecular molecular docking molecular dynamics organism pandemic physicochemical polyphenols Prevent protease RBD Receptor binding domain Replication SARS-CoV-2 SARS-CoV-2 cell serine 2 Spike protein Structural properties target target receptor targets the SARS-CoV-2 TMPRSS2 transmembrane [DOI] 10.3390/ijms23052643 PMC 바로가기 [Article Type] Article
Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid RaftsImmunology Published on 2022-02-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 affected Calu-3 cell caused cell entry cell membrane Clinical studies coronavirus 2 Coronavirus disease 2019 Course COVID-19 dependent on Disruption downregulated exhibit experimental evidence hospitalized patient human neutrophils in vitro in vivo Infection Inflammation inflammatory cytokine production Inflammatory response inhibiting Lipid Lipid rafts lung damage lung epithelial mechanism mice modulate Monocytes Mortality Peripheral blood protective effect raft reduced reported respiratory response SARS-CoV-2 SARS-COV-2 infection significantly Simvastatin statin systemically tissue Treatment triggered viral replication virus with COVID-19 [DOI] 10.3389/fimmu.2022.820131 PMC 바로가기 [Article Type] Immunology
Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design퓨린 억제제로서 COVID-19에 대응하는 ta-Defensins: 인실리코 효율성 예측 및 새로운 화합물 설계Research Article Published on 2022-02-092022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Anti-inflammatory antigenicity antimicrobial peptide antimicrobial peptides arginine bind binding binding site caused Cell cell membrane characterized Compound coronavirus coronavirus disease Coronavirus disease 2019 counter COVID-19 COVID-19 infection Defense defense mechanisms defensin docking docking analysis drug candidate drug candidates Efficiency electrostatic enzyme event furin furin inhibitors Health Organization in silico approaches in vitro in vivo infect Inflammatory inhibit investigated mechanism mechanisms molecules novel pandemic peptide peptides Potential treatment prediction respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein Spike proteins stability Stage subclass the cell the spike protein therapeutic unique WHO World Health Organization [DOI] 10.1155/2022/9735626 PMC 바로가기 [Article Type] Research Article