Cell-cell communication analysis for single-cell RNA sequencing and its applications in carcinogenesis and COVID-19Review article Published on 2022-08-012022-10-05 Journal: Biosafety and Health [Category] 변종, 유전자 메커니즘, [키워드] accelerate Analysis blocked Carcinogenesis Cell cell types Cell-cell communication complex computational approach COVID-19 database detect disease facilitate Interaction intercellular Ligand-receptor pair occur physiological SARS-COV-2 infection scRNA-seq scRNA-seq data Signaling Single-cell RNA sequencing [DOI] 10.1016/j.bsheal.2022.03.001 [Article Type] Review article
Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factorsPCOS가 있는 여성의 난소 과립막 세포는 낮은 수준의 SARS-CoV-2 수용체 및 보조 인자를 발현합니다Article Published on 2022-08-012022-09-11 Journal: Archives of gynecology and obstetrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus BSG cardiovascular disease Cell cell types co-morbidities controls coronavirus COVID-19 CTSB CTSL datasets death diabetes DPP4 Express expresse expression Factor feature global pandemic granulosa healthy help Human in vitro In vitro fertilization indicate Infection investigated IVF knowledge Lower lower expression material Microarray microarray data morbidities obesity Oocyte organ ovarian ovarian follicle Ovarian granulosa cells Ovary pandemic PCOS polycystic ovary protease receptor reproductive risk Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility susceptible syndrome tissue TMPRSS2 Type-2 diabetes mellitus women [DOI] 10.1007/s00404-022-06567-4 PMC 바로가기 [Article Type] Article
Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infectionSARS-CoV-2 감염 시 인터페론 유도, 회피 및 역설적 역할Review Published on 2022-08-012022-09-11 Journal: Immunological reviews [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alleviate antiviral immunity causative agent caused cell type cell types coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death deficiency disease disease severity effort evade function IFN IFN response IFNs immune immune evasion interferon interferon. interferons interferons (IFNs location mechanism outcome paradoxical pathway Pathways Protective Research responses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly supported Therapeutics Treatment treatment of COVID-19 Type type I Type I and III IFN virus while [DOI] 10.1111/imr.13113 PMC 바로가기 [Article Type] Review
Deregulation of ceRNA Networks in Frontal Cortex and Choroid Plexus of Brain during SARS-CoV-2 Infection Aggravates Neurological Manifestations: An Insight from Bulk and Single-Cell Transcriptomic AnalysesSARS-CoV-2 감염 중 뇌의 전두엽 피질 및 맥락총 신경총에서 ceRNA 네트워크의 규제 완화는 신경 증상을 악화시킵니다: 대량 및 단일 세포 전사체 분석의 통찰력Article Published on 2022-08-012022-09-11 Journal: Advanced Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analysis analyzed Brain cell type cell types choroid Choroid plexus competing competing endogenous RNA network cortex deregulated differentially expressed downregulated downregulation downstream excitatory explain Frontal Gene Expression help Human brain impairment indicated Initially insight landscape lncRNA MALAT1 mapping mechanism MIRLET7BHG miRNA miRNA. miRNAs mRNA NEAT1 network neurological Neuron neurons NorAD pathway enrichment Plexus reconstructed regulatory circuit RNA RNA-Seq SARS-CoV-2 single-cell RNA-seq STXBP5 STXBP5-AS1 therapeutic Therapeutics transcriptomic upregulated upregulation Variability [DOI] 10.1002/adbi.202101310 PMC 바로가기 [Article Type] Article
ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19지방 조직에서의 ACE2 발현은 코로나19에 대한 심장 대사 위험 인자 및 세포 유형 구성과 관련이 있습니다.Meta-Analysis Published on 2022-08-012022-09-11 Journal: International journal of obesity (2005) [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 ACE2 expression adipose Adipose tissue age angiotensin angiotensin I angiotensin I converting enzyme 2 BMI Cell cell type cell types cellular entry contribute COVID-19 COVID-19 severity diabetes Diseases distal Endothelial cell enzyme eQTLs expression Factor Factors fasting insulin feature Genetic HDL Health identify increased risk independent individual insulin investigated loci Lower lower expression Macrophage macrophages Meta-analysis obesity participant pathophysiology phenotypic proportion proximal Quantitative receptor risk risk factor RNA-Seq SARS-CoV-2 serum severe COVID-19 T2D tissue tissue expression type 2 diabete type 2 diabetes [DOI] 10.1038/s41366-022-01136-w PMC 바로가기 [Article Type] Meta-Analysis
DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndromeDecodeME: 근육통 뇌척수염/만성 피로 증후군의 대규모 유전학 연구를 위한 커뮤니티 모집Article Published on 2022-07-192022-09-11 Journal: BMC Neurology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] aetiology approach association causes cell type cell types cellular processe cellular processes Chronic fatigue chronic fatigue syndrome Clinical diagnosis Co-production Community contributing to controls criteria diagnose Diagnosis diagnostic diagnostic test digital marketing disease DNA effective effective therapy eligible Encephalomyelitis ethics committee fatigue fatigue syndrome funding generate Genes genetic data genetics Genome-wide association study genomic Genotype hypothese hypotheses identification IMPROVE include individuals International intervals Involvement knowledge lack malaise mechanism media myalgic encephalomyelitis North Open Access paper participant Participation Patient and Public Involvement. Public Questionnaires recruitment Relieved by reported Research Ethics Result risk Saliva SARS-COV-2 infection significantly social media Treatment UK biobank variant website West [DOI] 10.1186/s12883-022-02763-6 PMC 바로가기 [Article Type] Article
Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease Reviews Published on 2022-07-152022-10-05 Journal: Nature reviews. Cardiology [Category] 바이오마커, [키워드] Affect arteries Artery atherosclerotic atherosclerotic plaques cardiovascular disease cell types changes in circulation clinical study demonstrated described dysfunction endothelial cells endotoxaemia Factor Gram-negative bacteria Gut IMPROVE Inflammation intestinal leukocytes lipopolysaccharide LPS mechanism membrane Patient plaque instability Platelet pro-inflammatory status promote review risk risk factor suggested systemic systemic inflammation therapeutic thrombus formation translocation [DOI] 10.1038/s41569-022-00737-2 [Article Type] Reviews
Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion말초 혈액 단핵 세포의 차별적인 염색질 접근성은 혈청 전환 이전의 COVID-19 질병 중증도의 기초가 됩니다Article Published on 2022-07-092022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제, [키워드] Accessibility anti-spike protein IgG Antiviral ATAC-seq CD14 CD14+ monocytes Cell cell differentiation cell type cell types changes in chromatin classical Course COVID-19 COVID-19 disease severity defined diagnostic disease disease course dysregulated early disease effective epigenome Evolution hosts IgG immune response immune responses individual Infection interleukin interleukin signaling IRF1 IRF7 less Mild mild SARS-CoV-2 infection Mild symptom moderate moderate disease moderate symptom Modification modifications Monocytes mononuclear cell mononuclear cells morphology motif observation occurred offer Outpatient outpatients Pathways PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells profile promise Regulation remodeling responses RNA-Seq robust SARS-CoV-2 SARS-COV-2 infection Sequencing Seroconversion severity Signaling single-cell analyses single-cell analysis Stage Symptom symptom severity the disease transcription factor transposase Trigger triggers upregulation with COVID-19 [DOI] 10.1038/s41598-022-15668-8 PMC 바로가기 [Article Type] Article
Major bat-borne zoonotic viral epidemics in Asia and Africa: A systematic review and meta-analysis아시아 및 아프리카의 주요 박쥐 매개 인수공통 바이러스 전염병: 체계적인 검토 및 메타 분석Review Published on 2022-07-012022-09-11 Journal: Veterinary medicine and science [Category] 치료기술, [키워드] African analysed Asia Asian bat bat-human interface bats Case fatality rate case fatality rates caused cell types cellular tropism Coronaviruses COVID-19 pandemic Descriptive statistics dimension Diseases Ebola Ebola virus ENhance Epidemic Epidemics epidemiological estimate event followed by Host Human humans India infect intermediate host introduced Major Malaysia MERS Meta-analysis natural reservoir Neurological disorder Neurological disorders Nipah virus outbreak pandemic passages pathogenic random effect Reservoir host Risk factors spillover STATA/IC susceptibility systematic review viral epidemics virus virus viruses zoonotic zoonotic disease zoonotic virus. [DOI] 10.1002/vms3.835 PMC 바로가기 [Article Type] Review
Identification of COVID-19-Associated DNA Methylation Variations by Integrating Methylation Array and scRNA-Seq Data at Cell-Type Resolution세포 유형 분해능에서 메틸화 어레이 및 scRNA-Seq 데이터를 통합하여 COVID-19 관련 DNA 메틸화 변이 식별Article Published on 2022-06-212022-09-11 Journal: Genes [Category] MERS, 바이오마커, [키워드] AHNAK antiviral activity biological processe Biomarker cell type cell types COVID-19 COVID-19 patient COVID-19 patients CX3CR1 Cytokines DNA DNA methylation DNAm variation gene Epigenetic FIVE identification immune immune dysfunction immune response immune responses Inflammatory response knowledge LFNG low expression lymphopenia Methylation methylation array phenomenon play roles pro-inflammatory cytokines regulated Regulation reported Resolution S100A9 scRNA-seq scRNA-seq. signaling pathways single-cell single-cell level specificity T cell T cells TRAF3IP3 Transcriptome Variation Whole blood [DOI] 10.3390/genes13071109 PMC 바로가기 [Article Type] Article